Sharmina Deloer
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View article: LRRK2-mediated NLRC4 phosphorylation differentially regulates IL-1β/IL-18 secretion
LRRK2-mediated NLRC4 phosphorylation differentially regulates IL-1β/IL-18 secretion Open
In the present study, we explored the relation of LRRK2-kinase phosphorylation of the NLRC4 inflammasome to NLRC4 inflammasome function in normal humans and mice, as well as in patients with Crohn’s disease (CD). We found that LRRK2-kinase…
View article: Inhibition of LRRK2 Kinase Activity with a Novel Inhibitor (CS 82) Inhibits NLRC4 Inflammasome Activation and Reduces Intestinal Inflammation Severity
Inhibition of LRRK2 Kinase Activity with a Novel Inhibitor (CS 82) Inhibits NLRC4 Inflammasome Activation and Reduces Intestinal Inflammation Severity Open
In the last twenty years Leucine Rich Repeat Kinase 2 (LRRK2) has received immense attention due to its association with several diseases, for example, neurodegenerative disease PD (Parkinson’s Disease), inflammatory bowel disease (IBD), C…
View article: Correction: Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel
Correction: Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel Open
[This corrects the article DOI: 10.1371/journal.pntd.0008518.].
View article: Stage-Specific <i>De Novo</i> Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to <i>Entamoeba</i> Parasites
Stage-Specific <i>De Novo</i> Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to <i>Entamoeba</i> Parasites Open
Entamoeba is a protozoan parasite that thrives in its niche by alternating its two forms between a proliferative trophozoite and dormant cyst. Cysts are the only form able to transmit to a new host and are differentiated from trophozoites …
View article: Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel
Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel Open
To eliminate schistosomiasis, appropriate diagnostic tests are required to monitor its prevalence and transmission, especially in the settings with low endemicity resulting from the consecutive mass drug administration. Antibodies that rea…
View article: Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice
Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice Open
View article: Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis
Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis Open
Hence, the combined approach of in silico and in vitro-based EhAPSK analyses identified compounds that can be evaluated for their effects on Entamoeba. This can provide leads for the development of new anti-amoebic and amoebiasis transmiss…
View article: Antibacterial Properties of Essential Oil (EO) Extracted from Nigella sativa Linn. (Black cumin) and its Application Against Vibrio cholerae in Ground Chicken Meat
Antibacterial Properties of Essential Oil (EO) Extracted from Nigella sativa Linn. (Black cumin) and its Application Against Vibrio cholerae in Ground Chicken Meat Open
Chemical preservatives for food preservation at high concentration are hazardous for public health. The natural antimicrobials from plants, herbs and spices have been given priority as alternatives of the chemical preservatives. In this st…
View article: Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes
Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes Open
Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics. Epidemiological surveys have revealed coinfection rates of up to 30% among children in Sub-Saharan Africa. To investigate the impact o…
View article: IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis
IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis Open