Sharon Fleischer
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A custom preservation solution extends the ex vivo availability of living heart valves for transplantation Open
Normothermic preservation of living valves can support tissue viability for at least 7 weeks ex vivo. With additional preclinical validation, stored living valves could act as a tissue source for heart valve transplantation, with key advan…
MicroRNAs won the Nobel Prize. Now, can extracellular vesicles help them become drugs? Open
The 2024 Nobel Prize recognized microRNAs (miRNAs) as transformative regulators of gene expression. However, their clinical potential has been constrained by instability and delivery challenges. Extracellular vesicles (EVs), as natural car…
Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform (Adv. Sci. 42/2024) Open
Human Organ‐on‐Chip Platform This cover displays an astronaut holding an organ‐on‐a‐chip model of heart, liver, and bone marrow tissues linked by vascular flow. This graphical representation illustrates the capability of organ‐on‐achip mod…
An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury Open
Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease that affects multiple organs, including the heart. The mechanisms of myocardial injury in SLE remain poorly understood. In this study, we engineered human cardiac tiss…
SARS-CoV-2 pathogenesis in an angiotensin II–induced heart-on-a-chip disease model and extracellular vesicle screening Open
Adverse cardiac outcomes in COVID-19 patients, particularly those with preexisting cardiac disease, motivate the development of human cell-based organ-on-a-chip models to recapitulate cardiac injury and dysfunction and for screening of car…
Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform Open
Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiatio…
Macrophages enhance contractile force in iPSC-derived human engineered cardiac tissue Open
Resident cardiac macrophages are critical mediators of cardiac function. Despite their known importance to cardiac electrophysiology and tissue maintenance, there are currently no stem-cell-derived models of human engineered cardiac tissue…
An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury Open
Systemic lupus erythematosus (SLE) is a highly heterogenous autoimmune disease that affects multiple organs, including the heart. The mechanisms by which myocardial injury develops in SLE, however, remain poorly understood. Here we enginee…
BeatProfiler: Multimodal In Vitro Analysis of Cardiac Function Enables Machine Learning Classification of Diseases and Drugs Open
Goal: Contractile response and calcium handling are central to understanding cardiac function and physiology, yet existing methods of analysis to quantify these metrics are often time-consuming, prone to mistakes, or require specialized eq…
Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery Open
Restrictive cardiomyopathy (RCM) is defined as increased myocardial stiffness and impaired diastolic relaxation leading to elevated ventricular filling pressures. Human variants in filamin C (FLNC) are linked to a variety of cardiomyopathi…
Emerging Trajectories for Next Generation Tissue Engineers Open
The field of tissue engineering has evolved from its early days of engineering tissue substitutes to current efforts at building human tissues for regenerative medicine and mechanistic studies of tissue disease, injury, and regeneration. A…
A framework for developing sex-specific engineered heart models Open
The convergence of tissue engineering and patient-specific stem cell biology has enabled the engineering of in vitro tissue models that allow the study of patient-tailored treatment modalities. However, sex-related disparities in health an…
milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues Open
Engineered cardiac tissues derived from human induced pluripotent stem cells (iPSCs) are increasingly used for drug discovery, pharmacology and in models of development and disease. While there are numerous platforms to engineer cardiac ti…
Engineered Microvasculature: From Arteries to Capillaries: Approaches to Engineering Human Vasculature (Adv. Funct. Mater. 37/2020) Open
In article number 1910811, Gordana Vunjak-Novakovic, Sharon Fleischer, and Daniel Naveed Tavakol review approaches to engineering the human vascular tree, ranging from millimeter-sized arteries to micro-scaled capillaries. Strategies for e…
From Arteries to Capillaries: Approaches to Engineering Human Vasculature Open
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple scales and cell types. The convergence of bioengineering, materials science, and stem cell biology has enabled tissue engineers to recreate the stru…
Endomyocardial biopsies in the diagnosis of myocardial involvement in systemic lupus erythematosus Open
Background Endomyocardial biopsy (EMB) is considered the gold standard for diagnosing myocardial involvement in most inflammatory conditions, including systemic lupus erythematosus (SLE). However, EMBs are rarely performed, and most of the…
Channeled ECM-Based Nanofibrous Hydrogel for Engineering Vascularized Cardiac Tissues Open
Hydrogels are widely used materials for cardiac tissue engineering. However, once the cells are encapsulated within hydrogels, mass transfer to the core of the engineered tissue is limited, and cell viability is compromised. Here, we repor…
View article: Electrical Conductivity, Selective Adhesion, and Biocompatibility in Bacteria‐Inspired Peptide–Metal Self‐Supporting Nanocomposites
Electrical Conductivity, Selective Adhesion, and Biocompatibility in Bacteria‐Inspired Peptide–Metal Self‐Supporting Nanocomposites Open
Bacterial type IV pili (T4P) are polymeric protein nanofibers that have diverse biological roles. Their unique physicochemical properties mark them as a candidate biomaterial for various applications, yet difficulties in producing native T…
View article: Personalized Tissue Implants: Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants (Adv. Mater. 1/2019)
Personalized Tissue Implants: Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants (Adv. Mater. 1/2019) Open
Personalized hydrogels for engineering patient-specific tissues are reported by Tal Dvir and co-workers in article number 1803895. A small fatty tissue biopsy is taken from the patient by a minimally invasive procedure and the cellular and…
Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR Open
Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. To address this issue, we developed facile and safe, suture-free te…
Modular assembly of thick multifunctional cardiac patches Open
Significance Heart disease is the primary cause of death in the United States. Cardiac tissue engineering has evolved with the goal of creating heart patches to treat end-stage patients. Here, we report on a bottom-up approach to assemble …