Sharon L. Longo
YOU?
Author Swipe
View article: Figure 3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Figure 3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Fibulin-3 regulates the expression of immunosuppressive signals in GBM cells. A, Transient transfection of fibulin-3 siRNAs in GSCs results in decreased expression of CSF-1, TGF-β1, and the innate immune checkpoint CD47. B, S…
View article: Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S5. Characterization of fibulin-3 effects and anti-fibulin-3 targeting in fibulin-3-null cells.
View article: Supplementary Table S-I from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Table S-I from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Table S-I. Antibodies used for Western blotting, flow cytometry, or immunohistochemistry.
View article: Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S10 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S10. Anti-fibulin-3 promotes in vitro phagocytosis of GBM cells by macrophages.
View article: Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S3 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S3. Correlation of fibulin-3 expression with immunosuppressive signals in GBM.
View article: Figure 5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Figure 5 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Anti–fibulin-3 antibody increases intratumoral presence of proinflammatory TAMs. A, Representative images of intracranial GSC-derived tumors (GBM09) treated with humanized anti–fibulin-3 mAb428.2 or its IgG control. Tissues were sta…
View article: Supplementary Figure S1 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S1 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S1. Validation of GBM stem cells and equivalence of humanized mAb428.2 to original mAb428 antibody.
View article: Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S8 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S8. Fibulin-3 is upregulated by macrophage signals.
View article: Data from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Data from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Glioblastoma (GBM) tumors remain a challenge for immunotherapy owing to their heterogeneous and immunologically cold properties. GBM cells change the composition of the neural extracellular matrix (ECM), affecting the mobility, survival, a…
View article: Figure 2 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Figure 2 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Fibulin-3 expression correlates with an immunosuppressive signature in GBM. A, Correlation of fibulin-3 mRNA expression with the expression of CSF-1, TGF-β1, and the checkpoints CD47 and CD274 (PD-L1), extracted from The Cancer Geno…
View article: Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S4. Fibulin-3 knockdown does not affect the expression of some immune checkpoints.
View article: Supplementary Figure S6 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S6 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S6. Fibulin-3 induces p65/RelA binding to the CSF1 promoter.
View article: Figure 1 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Figure 1 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Fibulin-3 expression affects the accumulation and phenotype of TAMs. A, Representative images of GSC-derived intracranial tumors (GBM08 line) expressing control or fibulin-3 short hairpin RNAs (shRNA), showing TAM density (IBA1 stai…
View article: Figure 4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Figure 4 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Fibulin-3 regulates the expression of immunomodulatory signals in GBM cells via NF-κB signaling. A, Expression of CSF-1 mRNA in U251MG cells cotransfected with fibulin-3 cDNA and p65/RelA siRNA, or their respective controls. B–D,…
View article: Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S7 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S7. Anti-fibulin-3 treatment decreases immunosuppression in GBM.
View article: Supplementary Figure S2 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S2 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Figure S2. Analysis of TAMs in intracranial tumors by quantitative immunohistochemistry.
View article: Supplementary Table S-II from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Table S-II from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Table S-II. Sequences of oligonucleotides and primers used for q-RTPCR.
View article: Figure 6 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Figure 6 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Anti–fibulin-3 induces macrophage attack of GBM cells. A, Quantification of cytotoxicity in fLuc-expressing GBM cells co-cultured with U937 macrophages (effector:target = 5:1) in the presence of anti–fibulin-3 mAb428.2, control IgG,…
View article: Supplementary Figure Legends from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure Legends from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Supplementary Figure Legends 1-10 and Supplementary Tables 1-2.
View article: Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Supplementary Figure S9 from Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Supplementary Figure S9. Anti-fibulin-3 triggers myeloid cell attack against syngeneic GBM cells.
View article: Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma Open
Glioblastoma (GBM) tumors remain a challenge for immunotherapy owing to their heterogeneous and immunologically cold properties. GBM cells change the composition of the neural extracellular matrix (ECM), affecting the mobility, survival, a…
View article: Inhibition of the extracellular matrix protein fibulin-3 reduces immunosuppressive signaling in tumor stem cells and increases macrophage activation against glioblastoma
Inhibition of the extracellular matrix protein fibulin-3 reduces immunosuppressive signaling in tumor stem cells and increases macrophage activation against glioblastoma Open
Glioblastoma tumors remain a formidable challenge for immune-based treatments because of their molecular heterogeneity, poor immunogenicity, and growth in the largely isolated and immunosuppressive neural environment. As the tumor grows, G…
View article: Figures S1 to S8 from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Figures S1 to S8 from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Figure S1: Generation of mAb428.2 antibody; Figure S2: Affinity of mAb428.2 for fibulin-3; Figure S3: mAb428.2 binds to cell-surface and interstitial fibulin-3; Figure S4: mAb428.2 does not cause acute toxicity; Figure S5: Locally-delivere…
View article: Legends of Figs S1 to S8 unmarked from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Legends of Figs S1 to S8 unmarked from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Legends of Figs S1 to S8, unmarked version
View article: Figures S1 to S8 from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Figures S1 to S8 from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Figure S1: Generation of mAb428.2 antibody; Figure S2: Affinity of mAb428.2 for fibulin-3; Figure S3: mAb428.2 binds to cell-surface and interstitial fibulin-3; Figure S4: mAb428.2 does not cause acute toxicity; Figure S5: Locally-delivere…
View article: Data from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Data from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Purpose: We sought a novel approach against glioblastomas (GBM) focused on targeting signaling molecules localized in the tumor extracellular matrix (ECM). We investigated fibulin-3, a glycoprotein that forms the ECM scaffold of GBM…
View article: Suppl Tables I and II from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Suppl Tables I and II from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Supplemental Table I: Antibodies used for Western blotting and immunohistochemistry (IHC); Supplemental Table II: Sequences used for qRT-PCR primers.
View article: Legends of Figs S1 to S8 unmarked from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Legends of Figs S1 to S8 unmarked from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Legends of Figs S1 to S8, unmarked version
View article: Suppl Tables I and II from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Suppl Tables I and II from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Supplemental Table I: Antibodies used for Western blotting and immunohistochemistry (IHC); Supplemental Table II: Sequences used for qRT-PCR primers.
View article: Data from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Data from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma Open
Purpose: We sought a novel approach against glioblastomas (GBM) focused on targeting signaling molecules localized in the tumor extracellular matrix (ECM). We investigated fibulin-3, a glycoprotein that forms the ECM scaffold of GBM…