Sharon Zahra
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View article: Comparison of Operative Outcomes of Open Thyroidectomy with Electrothermal Bipolar Vessel Sealer versus Conventional Hemostasis for Benign Thyroid Swelling in Adults Population
Comparison of Operative Outcomes of Open Thyroidectomy with Electrothermal Bipolar Vessel Sealer versus Conventional Hemostasis for Benign Thyroid Swelling in Adults Population Open
Precise dissection and effective hemostasis are crucial for safe thyroid surgery. The bipolar vessel sealer, a first-generation electrosurgical instrument, is widely used in thyroidectomies to improve hemostasis, reduce tissue trauma, shor…
View article: Fear of Childbirth, Desire to Avoid Pregnancy and Marital Adjustment Among Married Females
Fear of Childbirth, Desire to Avoid Pregnancy and Marital Adjustment Among Married Females Open
With the advancement in the world, there are many phenomena that are increasing, but the Fear of childbirth is still an issue that goes unnoticed. Birth is a unique and also a painful experience for a woman. It is recognized that because o…
View article: The infected blood inquiry report—lessons for gamete donation
The infected blood inquiry report—lessons for gamete donation Open
Donation of substances of human origin (SoHO) is essential for the treatment of many patients and ranges from the donation of whole organs to the donation of tissue or cell products, including also gamete donation. In order to ensure the s…
View article: Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK
Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK Open
Introduction Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively-activated macrophages (AAM…
View article: EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation
EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation Open
Adoptive immunotherapy with Epstein–Barr virus (EBV)-specific T cells is an effective treatment for relapsed or refractory EBV-induced post-transplant lymphoproliferative disorders (PTLD) with overall survival rates of up to 69%. EBV-speci…
View article: Macrophage Therapy for Acute Liver Injury (MAIL): a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-induced Acute Liver Injury
Macrophage Therapy for Acute Liver Injury (MAIL): a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-induced Acute Liver Injury Open
Introduction Acute Liver Failure (ALF) has no effective treatment other than liver transplantation, and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively activated macrophages (AA…
View article: Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19
Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19 Open
COVID-19 disease caused by the SARS-CoV-2 virus is characterized by dysregulation of effector T cells and accumulation of exhausted T cells. T cell responses to viruses can be corrected by adoptive cellular therapy using donor-derived viru…
View article: British Society of Haematology Guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: their handling and use in various patient groups in the absence of major bleeding (<i>Br J Haematol</i>. 2018;181:54–67). Addendum August 2020
British Society of Haematology Guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: their handling and use in various patient groups in the absence of major bleeding (<i>Br J Haematol</i>. 2018;181:54–67). Addendum August 2020 Open
Following publication of the British Society of Haematology (BSH) guideline on the spectrum of fresh frozen plasma (FFP) and cryoprecipitate products,1 there have been a number of changes requiring this addendum, prior to revision of the g…
View article: How donor selection criteria can be evaluated with limited scientific evidence: lessons learned from the TRANSPOSE project
How donor selection criteria can be evaluated with limited scientific evidence: lessons learned from the TRANSPOSE project Open
Background and objective Donor selection criteria (DSC) are a vital link in the chain of supply of Substances of Human Origin (SoHO) but are also subject to controversy and differences of opinion. Traditionally, DSC have been based on appl…
View article: Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for COVID-19
Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for COVID-19 Open
COVID-19 disease caused by the SARS-CoV-2 virus is characterized by dysregulation of effector T cells and accumulation of exhausted T cells. T cell responses to viruses can be corrected by adoptive cellular therapy using donor-derived viru…
View article: British Society of Haematology Guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: their handling and use in various patient groups in the absence of major bleeding
British Society of Haematology Guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: their handling and use in various patient groups in the absence of major bleeding Open
This guideline was compiled according to the BSH process at (http://www.bcshguidances.com/BCSH_PROCESS/42_EVIDENCE_LEVELS_AND_GRADES_OF_RECOMMENDATION.html). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nom…
View article: Allosensitization Following Bone Graft
Allosensitization Following Bone Graft Open
It is recognized that patients may become sensitized to donor-specific HLA antigens as a result of previous antigenic exposures, classically through previous transplantation, pregnancy, or blood transfusion. We present an unusual case of a…
View article: Addendum to the British Committee for Standards in Haematology (<scp>BCSH</scp>): guidelines for the use of fresh‐frozen plasma, cryoprecipitate and cryosupernatant, 2004 (Br. J Haematol 2004,126,11‐28) ‐ response to Neisser‐Svae and Heger
Addendum to the British Committee for Standards in Haematology (<span>BCSH</span>): guidelines for the use of fresh‐frozen plasma, cryoprecipitate and cryosupernatant, 2004 (Br. J Haematol 2004,126,11‐28) ‐ response to Neisser‐Svae and Heger Open
We thank Neisser-Svae and Heger for their interest in the addendum publication (Green et al, 2017), and for sharing their data of thawed solvent detergent-treated fresh frozen plasma (SDFFP) for up to 5 days (Neisser-Svae et al, 2016). We …
View article: Addendum to the British Committee for Standards in Haematology (BCSH): Guidelines for the use of fresh‐frozen plasma, cryoprecipitate and cryosupernatant, 2004 (Br. J Haematol 2004,126,11‐28)
Addendum to the British Committee for Standards in Haematology (BCSH): Guidelines for the use of fresh‐frozen plasma, cryoprecipitate and cryosupernatant, 2004 (Br. J Haematol 2004,126,11‐28) Open
The guideline on the use of fresh-frozen plasma (FFP), cryoprecipitate and cryosupernatant (British Committee for Standards in Haematology, Blood Transfusion Task Force, 2004) is currently under review. While the guideline is being reviewe…