David Shasha
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View article: Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis
Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis Open
Eosinophils are innate immune cells with central roles in allergy, parasitic diseases and multiple inflammatory conditions. Moreover, their role in host-pathogen interactions has been well characterized. However, the role of eosinophils du…
View article: High rates of Dientamoeba fragilis and Blastocystis species in children’s stool but minor clinical significance
High rates of Dientamoeba fragilis and Blastocystis species in children’s stool but minor clinical significance Open
While DF and Bs are frequently detected in pediatric stool samples, their clinical significance appears to be limited.
View article: The Impact of FDA-Approved Novel Agents for Steroid-Refractory Chronic Graft vs. Host Disease on Treatment Patterns and Outcomes—A Single-Center Longitudinal Cohort Analysis
The Impact of FDA-Approved Novel Agents for Steroid-Refractory Chronic Graft vs. Host Disease on Treatment Patterns and Outcomes—A Single-Center Longitudinal Cohort Analysis Open
Objectives—chronic graft vs. host disease (cGVHD) is associated with substantial morbidity and mortality. We aimed to analyze advances in treatment strategy and outcomes during the last decade due to the incorporation of novel immunosuppre…
View article: Early Antibiotic Deescalation and Discontinuation in Patients with Febrile Neutropenia after Cellular Therapy: A Single-Center Prospective Unblinded Randomized Trial
Early Antibiotic Deescalation and Discontinuation in Patients with Febrile Neutropenia after Cellular Therapy: A Single-Center Prospective Unblinded Randomized Trial Open
The optimal duration of empiric antimicrobial therapy of febrile neutropenia in patients after cellular therapy is unclear. Early deescalation has been suggested by some authorities; however, data are lacking for cellular therapy recipient…
View article: Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response
Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response Open
Metabolic adaptations regulate the response of macrophages to infection. The contributions of metabolism to macrophage interactions with the emerging fungal pathogen Candida auris are poorly understood. Here, we show that C. auris-infected…
View article: Early antibiotic de-escalation and discontinuation in Patients with Febrile Neutropenia after Cellular Therapy: A Single Center Prospective Unblinded Randomized Trial
Early antibiotic de-escalation and discontinuation in Patients with Febrile Neutropenia after Cellular Therapy: A Single Center Prospective Unblinded Randomized Trial Open
Background - The optimal duration and spectrum of empiric antimicrobial therapy of febrile neutropenia in patients after cellular therapy is unclear. Early de-escalation has been suggested by several groups, however studies exclusively foc…
View article: <i>Candida auris</i>evades innate immunity by using metabolic strategies to escape and kill macrophages while avoiding antimicrobial inflammation
<i>Candida auris</i>evades innate immunity by using metabolic strategies to escape and kill macrophages while avoiding antimicrobial inflammation Open
Candida auris causes life-threatening, drug-resistant infections. In addition to drug resistance, therapeutic innovation is hindered by our limited knowledge of the mechanisms used by C. auris to evade immunity and establish infection. Her…
View article: Systematic Review and Meta-analysis of Foodborne Tickborne Encephalitis, Europe, 1980–2021
Systematic Review and Meta-analysis of Foodborne Tickborne Encephalitis, Europe, 1980–2021 Open
Tick-borne encephalitis (TBE) is a viral infection of the central nervous system that occurs in many parts of Europe and Asia. Humans mainly acquire TBE through tick bites, but TBE occasionally is contracted through consuming unpasteurized…
View article: Safety and Immunogenicity of the BNT162b2 mRNA COVID-19 Vaccine in Patients after Allogeneic HCT or CD19-based CART therapy—A Single-Center Prospective Cohort Study
Safety and Immunogenicity of the BNT162b2 mRNA COVID-19 Vaccine in Patients after Allogeneic HCT or CD19-based CART therapy—A Single-Center Prospective Cohort Study Open
Data are scarce regarding both the safety and immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in patients undergoing immune cell therapy; thus, we prospectively evaluated these two domains in patients receiving this vaccine after allo…
View article: BNT162b2 Vaccine Effectiveness in Preventing Asymptomatic Infection With SARS-CoV-2 Virus: A Nationwide Historical Cohort Study
BNT162b2 Vaccine Effectiveness in Preventing Asymptomatic Infection With SARS-CoV-2 Virus: A Nationwide Historical Cohort Study Open
Background There is strong evidence regarding the efficacy and effectiveness of the BNT162b2 vaccine in preventing symptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is a relative paucity of data…
View article: Anosmia and dysgeusia in patients with mild SARS-CoV-2 infection
Anosmia and dysgeusia in patients with mild SARS-CoV-2 infection Open
In this cohort of 42 patients with mild COVID19 we found a unique clinical feature of acute anosmia and dysgeusia in more than third of patients. Median onset of these features was 3.3 days after onset of illness (range 0-7) with rapid rec…
View article: 436. A survey of Schistosomiasis and Strongyloidiasis Among Eritrean Immigrants to Israel
436. A survey of Schistosomiasis and Strongyloidiasis Among Eritrean Immigrants to Israel Open
BACKGROUND: Immigration from east Africa (mainly Eritrea) to Israel peaked during 2011–2013. Little is known about the prevalence of chronic parasitic diseases in this population. We performed a survey of Schistosomiasis and Strongyloidias…
View article: Delayed diagnosis of colorectal sexually transmitted diseases due to their resemblance to inflammatory bowel diseases
Delayed diagnosis of colorectal sexually transmitted diseases due to their resemblance to inflammatory bowel diseases Open
Colorectal STDs may resemble IBD and therefore their diagnosis may be delayed. IBD symptoms in MSM who engage in non-protected anal sex should prompt at least syphilis and anal PCR for STD testing. If C. trachomatis is diagnosed but LGV su…
View article: Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors
Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors Open
Mechanisms modulating HIV-specific CD8+ T cell-mediated viral inhibition are not well defined. To delineate features of effective control, we compared the ability of CD8+ T cells from HIV ECs and CPs to inhibit HIV ex vivo. ECs showed supe…