Shashanka Murthy
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View article: CLAE: A High‐Fidelity Nanopore Sequencing Strategy for Read‐Level Viral Variant Detection and Environmental RNA Virus Discovery
CLAE: A High‐Fidelity Nanopore Sequencing Strategy for Read‐Level Viral Variant Detection and Environmental RNA Virus Discovery Open
High‐fidelity (HF) long‐read sequencing enables accurate profiling of microorganisms and pathogens at single‐molecule resolution. However, current Oxford Nanopore Technologies (ONT)—a revolutionary platform offering real‐time, portable seq…
View article: Clinical and Genomic Characteristics of Candida auris in Central Ohio: An Insight into Epidemiological Surveillance
Clinical and Genomic Characteristics of Candida auris in Central Ohio: An Insight into Epidemiological Surveillance Open
Background: Candida auris is an emerging threat to hospitalized patients and invasive disease is associated with high mortality. This study describes clinical and microbiological characteristics of nine patients identified with C. auris at…
View article: Use of Whole Genome Sequencing for Investigation of Potential Hospital-Acquired Vancomycin Resistant Enterococcus
Use of Whole Genome Sequencing for Investigation of Potential Hospital-Acquired Vancomycin Resistant Enterococcus Open
Background: Whole genome sequencing (WGS) is a relatively new method for analyzing outbreaks and modes of transmission, particularly for multidrug resistant bacteria. This study sought to investigate clusters of patients with genetically r…
View article: Live tracking of a plant pathogen outbreak reveals rapid and successive, multidecade plasmid reduction
Live tracking of a plant pathogen outbreak reveals rapid and successive, multidecade plasmid reduction Open
The geranium industry, valued at $4 million annually, faces an ongoing Xanthomonas hortorum pv. pelargonii (Xhp) pathogen outbreak. To track and describe the outbreak, we compared the genome structure across historical and globally distrib…
View article: Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates and evaluation of hospital-acquired infections
Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates and evaluation of hospital-acquired infections Open
Background: Multidrug-resistant organisms (MDROs) are increasingly implicated in nosocomial outbreaks worldwide. We evaluated whole-genome sequencing (WGS) as an adjunctive epidemiological tool to identify infection clusters and MDRO trans…
View article: Live tracking of a plant pathogen outbreak reveals rapid and successive, multidecade episome reduction
Live tracking of a plant pathogen outbreak reveals rapid and successive, multidecade episome reduction Open
Quickly understanding the genomic changes that lead to pathogen emergence is necessary to launch mitigation efforts and reduce harm. Often the evolutionary events that result in an epidemic typically remain elusive long after an outbreak, …