Shashi Bala Singh
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View article: Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?
Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2? Open
The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with r…
View article: Bridging the Gap: Investigating the State-of-the-Art Approaches in Oral Biologic Delivery and Their Role in Redefining Therapeutic Possibilities
Bridging the Gap: Investigating the State-of-the-Art Approaches in Oral Biologic Delivery and Their Role in Redefining Therapeutic Possibilities Open
Biopharmaceutical medications that originate from biological sources and processes are known as biologics. Biologics are now the most promising medications for oral use in treating a variety of illnesses. These illnesses may involve proble…
View article: Reliability and Criterion Validity of Physio Master Application for the Measurement of Cervical Range of Motion in Healthy Individuals
Reliability and Criterion Validity of Physio Master Application for the Measurement of Cervical Range of Motion in Healthy Individuals Open
The results demonstrated excellent intra-rater and inter-rater reliability, along with outstanding validity when compared to a digital goniometer. These findings indicate that the physio master application is a reliable and valid alternati…
View article: Amyand’s hernia: a case of right inguinoscrotal hernia with appendiceal content
Amyand’s hernia: a case of right inguinoscrotal hernia with appendiceal content Open
Introduction: Amyand’s hernia, a rare condition where the appendix becomes lodged in the inguinal canal, poses diagnostic challenges due to its varied clinical presentations and lack of distinctive radiological features. This case undersco…
View article: A study of monophasic supramolecular formulation of Sulpiride with P-glycoprotein efflux inhibitor to enhance solubility and intestinal permeability with molecular modeling insights
A study of monophasic supramolecular formulation of Sulpiride with P-glycoprotein efflux inhibitor to enhance solubility and intestinal permeability with molecular modeling insights Open
The aim of the study was to design and develop a supramolecular formulation of sulpiride (SUL) to enhance its solubility, dissolution, and permeability. This was accomplished by co-amorphizing SUL with Naringin (NARI) to improve its physic…
View article: Correction to: Necrostatin-1 S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis
Correction to: Necrostatin-1 S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis Open
View article: Microtubule acetylation dyshomeostasis in Parkinson’s disease
Microtubule acetylation dyshomeostasis in Parkinson’s disease Open
The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated axonal transport system. This mechanistically regulated system delivers cargos (proteins, mRNAs a…
View article: Natural disasters are a symptom of climate change: A case study of Kedarnath in Uttarakhand
Natural disasters are a symptom of climate change: A case study of Kedarnath in Uttarakhand Open
Abstract Unsustainable development practises lead to climate change, which in turn causes unexpected natural disasters. The Himalayas are particularly vulnerable to the effects of climate change. Anthropogenic activities,…
View article: GSK-3β: An exuberating neuroinflammatory mediator in Parkinson's disease
GSK-3β: An exuberating neuroinflammatory mediator in Parkinson's disease Open
Neuroinflammation is a critical degradative condition affecting neurons in the brain. Progressive neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease (PD) have been strongly linked to neuroinflammation. The tri…
View article: CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease
CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease Open
Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to correct the causative gene mutation and establish animal models in neurodegenerative disorders. Since no strategy developed until now could completel…
View article: Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson’s disease
Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson’s disease Open
Parkinson's disease (PD) is marked by the gradual degeneration of dopaminergic neurons and the intracellular build-up of Lewy bodies rich in α-synuclein protein. This impairs various aspects of the mitochondria including the generation of …
View article: Preparation and Evaluation of Modified Chitosan Nanoparticles Using Anionic Sodium Alginate Polymer for Treatment of Ocular Disease
Preparation and Evaluation of Modified Chitosan Nanoparticles Using Anionic Sodium Alginate Polymer for Treatment of Ocular Disease Open
Mucoadhesive nanoparticles offer prolonged drug residence time at the corneal epithelium by adhering to the mucous layer of the eye. Here, in this research investigation, voriconazole-loaded chitosan mucoadhesive nanoparticles (VCZ-MA-NPs)…
View article: Epigenetics in depression and gut-brain axis: A molecular crosstalk
Epigenetics in depression and gut-brain axis: A molecular crosstalk Open
Gut-brain axis is a dynamic, complex, and bidirectional communication network between the gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing various metabolic, neurodegenerative, and neuropsychiatric dis…
View article: Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson’s Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk
Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson’s Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk Open
Background: Parkinson’s disease (PD) is an age-related progressive multifactorial, neurodegenerative disease. The autophagy and Keap1-Nrf2 axis system are both implicated in the oxidative-stress response, metabolic stress, and innate immun…
View article: Instigation of the epoch of nanovaccines in cancer immunotherapy
Instigation of the epoch of nanovaccines in cancer immunotherapy Open
Cancer is an unprecedented proliferation of cells leading to abnormalities in differentiation and maturation. Treatment of primary and metastatic cancer is challenging. In addition to surgery, chemotherapy and radiation therapies have been…
View article: Neuroepigenetic Changes in DNA Methylation Affecting Diabetes-Induced Cognitive Impairment
Neuroepigenetic Changes in DNA Methylation Affecting Diabetes-Induced Cognitive Impairment Open
View article: Pathological and Therapeutic Advances in Parkinson’s Disease: Mitochondria in the Interplay
Pathological and Therapeutic Advances in Parkinson’s Disease: Mitochondria in the Interplay Open
Parkinson’s disease (PD) is the second most common neurodegenerative illness majorly affecting the population between the ages of 55 to 65 years. Progressive dopaminergic neuronal loss and the collective assemblage of misfolded alpha-synuc…
View article: Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease
Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease, affecting the elderly worldwide and causing significant movement impairments. The goal of PD treatment is to restore dopamine levels in the striatum and regulate…
View article: Meloxicam in Combating Clinical Mastitis
Meloxicam in Combating Clinical Mastitis Open
Mastitis has well-recognized harmful effects on dairy farm profitability. Furthermore, mastitis impairs the milk component synthesizing ability of secretary tissues. Various therapies are available for the treatment of clinical mastitis. M…
View article: Nanotechnological Advances for Nose to Brain Delivery of Therapeutics toImprove the Parkinson Therapy
Nanotechnological Advances for Nose to Brain Delivery of Therapeutics toImprove the Parkinson Therapy Open
Blood-Brain Barrier (BBB) acts as a highly impermeable barrier, presenting an impediment to the crossing of most classical drugs targeted for neurodegenerative diseases including Parkinson's disease (PD). About the nature of drugs and othe…
View article: Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development Open
Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of…
View article: Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder
Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder Open
Mitochondrial uncoupling proteins (UCP) are a part of the large family of mitochondrial solute carriers (SLC25s), concentrated in the inner mitochondrial membrane that carries protons from intermembrane space to the matrix. Further, some U…
View article: Roles of online social media platforms and artificial intelligence in diffusing the impact of COVID-19 as scientists find a cure
Roles of online social media platforms and artificial intelligence in diffusing the impact of COVID-19 as scientists find a cure Open
View article: COVID-19 outbreak
COVID-19 outbreak Open
View article: GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells
GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells Open
View article: An Approach to Manage Shweta Pradar – A Case Study
An Approach to Manage Shweta Pradar – A Case Study Open
Acharya Manu has said that happiness of human needs proper care and respect of woman. So, to keep our society happy and healthy, proper care of woman is the most important thing. Shweta Pradar is one of the most common problems faced by wo…
View article: Lipid polymer hybrid nanocarriers: Insights into synthesis aspects, characterization, release mechanisms, surface functionalization and potential implications
Lipid polymer hybrid nanocarriers: Insights into synthesis aspects, characterization, release mechanisms, surface functionalization and potential implications Open
Lipid polymer hybrid nanoparticles (LPHN) are novel systems which are potentially emerging in the era of nano-medicine. They are core-shell nanostructures which comprise of polymer and phospholipids used in the preparation of polymeric nan…
View article: Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?
Does skin permeation kinetics influence efficacy of topical dermal drug delivery system? Open
Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal bar…
View article: Clinical Study on Role and Efficacy of Lower Dose of Carboprost [125 μg] and its Comparision with Oxytocin [10 Units] in Prevention of Postpartum Haemorrhage in Caesarean Section
Clinical Study on Role and Efficacy of Lower Dose of Carboprost [125 μg] and its Comparision with Oxytocin [10 Units] in Prevention of Postpartum Haemorrhage in Caesarean Section Open
Introduction: Post-partum hemorrhage (PPH) is an important cause of maternal mortality accounting for nearly 25% of maternal deaths worldwide. It is reported to occur in ~4-6% of all deliveries, and the risk is significantly greater with c…
View article: Nanomedicine based approaches for combating viral infections
Nanomedicine based approaches for combating viral infections Open