Shaun N. Robertson
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View article: Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings
Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings Open
Chronic wound infections are generally of polymicrobial nature with aerobic and anaerobic bacteria, as well as fungi frequently observed in them. Wound treatment involves a series of steps, including debridement of the wound, flushing, and…
View article: Ciprofloxacin Poly(β-amino ester) Conjugates Enhance Antibiofilm Activity and Slow the Development of Resistance
Ciprofloxacin Poly(β-amino ester) Conjugates Enhance Antibiofilm Activity and Slow the Development of Resistance Open
To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are urgently needed. Bacterial biofilms are a particular concern in this context as they are responsible for over 80% of bacterial infections and are inher…
View article: Design, Synthesis, and Evaluation of New 1<i>H</i>-Benzo[<i>d</i>]imidazole Based PqsR Inhibitors as Adjuvant Therapy for <i>Pseudomonas aeruginosa</i> Infections
Design, Synthesis, and Evaluation of New 1<i>H</i>-Benzo[<i>d</i>]imidazole Based PqsR Inhibitors as Adjuvant Therapy for <i>Pseudomonas aeruginosa</i> Infections Open
Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a b…
View article: Co-assembling living material as an in vitro lung epithelial infection model
Co-assembling living material as an in vitro lung epithelial infection model Open
View article: Probing Interkingdom Signaling Molecules via Liquid Extraction Surface Analysis–Mass Spectrometry
Probing Interkingdom Signaling Molecules via Liquid Extraction Surface Analysis–Mass Spectrometry Open
Previously, metabolites diffused or secreted from microbial samples have been analyzed via liquid chromatography-mass spectrometry (LC-MS) approaches following lengthy extraction protocols. Here, we present a model system for growing biofi…
View article: Translational challenges and opportunities in biofilm science: a BRIEF for the future
Translational challenges and opportunities in biofilm science: a BRIEF for the future Open
View article: ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa
ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa Open
View article: ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa
ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa Open
Pseudomonas aeruginosa uses multiple protein regulators that work in tandem to control the production of a wide range of virulence factors and facilitate rapid adaptation to diverse environmental conditions. In this opportunistic pathogen,…
View article: Reduction of Pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration
Reduction of Pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration Open
View article: Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis
Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis Open
View article: Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis
Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis Open
In regenerative medicine, techniques which control stem cell lineage commitment are a rapidly expanding field of interest. Recently, nanoscale mechanical stimulation of mesenchymal stem cells (MSCs) has been shown to activate mechanotransd…
View article: Control of cell behaviour through nanovibrational stimulation: nanokicking
Control of cell behaviour through nanovibrational stimulation: nanokicking Open
Mechanical signals are ubiquitous in our everyday life and the process of converting these mechanical signals into a biological signalling response is known as mechanotransduction. Our understanding of mechanotransduction, and its contribu…
View article: Investigation of the antimicrobial properties of modified multilayer diamond-like carbon coatings on 316 stainless steel
Investigation of the antimicrobial properties of modified multilayer diamond-like carbon coatings on 316 stainless steel Open
View article: Utilisation and Dosage Patterns of Intravenous Echinocandins for Treatment of Invasive Fungal Infections Within Hospitals in England
Utilisation and Dosage Patterns of Intravenous Echinocandins for Treatment of Invasive Fungal Infections Within Hospitals in England Open
View article: The discovery, distribution and evolution of viruses associated with<i>Drosophila melanogaster</i>
The discovery, distribution and evolution of viruses associated with<i>Drosophila melanogaster</i> Open
A bstract Drosophila melanogaster is a valuable invertebrate model for viral infection and antiviral immunity, and is a focus for studies of insect-virus coevolution. Here we use a metagenomic approach to identify more than 20 previously u…