Explanipedia

Perioperative therapies for metastatic renal cell carcinoma Open

Matthew Lierz, Allen Siapno, Adam Khorasanchi, Shawn Dason, Yuanquan Yang , et al. · 2025

Systemic therapy for metastatic renal cell carcinoma (mRCC) has advanced considerably over the past decade. Studies of systemic therapies in the adjuvant, neoadjuvant, and now perioperative settings as solitary, dual, and triplet combinati…

Assessment of Patient Experience During Active Surveillance for Prostate Cancer Open

Devon M. Langston, Matthew J. DePuccio, Ann Scheck McAlearney, Sooyoung Kim, Alice A. Gaughan , et al. · 2025

Active surveillance is a preferred strategy for patients with low-risk prostate cancer to delay and/or avoid side effects of treatment. While its impact on health-related quality of life (HRQOL) has been studied, factors influencing follow…

Reno-Gonadal Venous Anastomosis for Right Renal Venous Drainage Following Juxtarenal Cavectomy for Renal Cell Carcinoma Open

Jon Simmons, Tae Hee Kim, Tasha Posid, Shawn Dason · 2025

This article is a case report of a 62-year-old male with a left-sided renal cell carcinoma (RCC) with a level II inferior vena cava (IVC) thrombus and caval occlusion. He was managed with open left radical nephrectomy and juxtarenal cavect…

Reno-Gonadal Venous Anastomosis for Right Renal Venous Drainage Following Juxtarenal Cavectomy for Renal Cell Carcinoma. Open

Jon Simmons, Tae Hee Kim, Tasha Posid, Shawn Dason · 2025

This article is a case report of a 62-year-old male with a left-sided renal cell carcinoma (RCC) with a level II inferior vena cava (IVC) thrombus and caval occlusion. He was managed with open left radical nephrectomy and juxtarenal cavect…

Right atrial metastasis after renal cell carcinoma operation: a case report Open

Meijuan Zhu, Yu Tang, Yawei Shen, Shawn Dason, Ashorne K. Mahenthiran , et al. · 2025

This case study highlights the rare clinical manifestations of cardiac metastasis from ccRCC. For patients who have the opportunity for surgery, surgical treatment is recommended as the preferred option. Early detection and treatment are t…

Metastasis-directed therapy in oligometastatic and oligoprogressive renal cell carcinoma Open

Shawn Dason, Shang-Jui Wang, Dominic Franceschelli, Eric A. Singer · 2024

Purpose of review This review addresses the evolving role of metastasis-directed therapy (MDT) in the management of oligometastatic and oligoprogressive renal cell carcinoma (RCC). With advances in both surgical techniques and stereotactic…

Role of Neoadjuvant Immunotherapy in Genitourinary Malignancies Open

Adam Khorasanchi, Karan Jatwani, Lingbin Meng, Katharine A. Collier, Debasish Sundi , et al. · 2024

Genitourinary (GU) malignancies are common and associated with significant morbidity and mortality. In patients with localized GU cancers, surgical resection or definitive radiation remain the mainstays of treatment. Despite definitive tre…

Perspectives and Misconceptions of an Online Adult Male Cohort Regarding Prostate Cancer Screening Open

Tyler Sheetz, Tasha Posid, Aliza Khuhro, Alicia Scimeca, Sarah L. Beebe , et al. · 2024

Introduction: Congruent with most guideline publishers, the Canadian Urological Association (CUA) recommends shared decision-making (SDM) on PSA screening (PSAS) for prostate cancer (PCa) following a discussion of its benefits and harms. H…

Perioperative systemic therapy in high-risk renal cell carcinoma following nephrectomy: a narrative review Open

Adam Khorasanchi, Taylor Goodstein, Shawn Dason, Eric A. Singer, Danielle Zimmerman , et al. · 2024

The optimal use of perioperative systemic therapy in high-risk RCC is an area of active investigation. The use of adjuvant TKIs failed to demonstrate a survival benefit and was limited by high rates of toxicity. Several neoadjuvant and adj…

Integrating artificial intelligence in renal cell carcinoma: evaluating ChatGPT’s performance in educating patients and trainees Open

J. Patrick Mershon, Tasha Posid, Keyan Salari, Richard S. Matulewicz, Eric A. Singer , et al. · 2024

ChatGPT has significant potential utility in medical education if it can continue to provide accurate and useful information. We have found it to be a useful adjunct to expert human guidance both for medical trainee and, less so, for patie…

Patient-Derived Conditionally Reprogrammed Cells in Prostate Cancer Research Open

Abdalla Elbialy, Deepthi Kappala, Dhruv Desai, Peng Wang, Ahmed Fadiel , et al. · 2024

Prostate cancer (PCa) remains a leading cause of mortality among American men, with metastatic and recurrent disease posing significant therapeutic challenges due to a limited comprehension of the underlying biological processes governing …

Active Surveillance in Metastatic Renal Cell Carcinoma Open

Nicholas Beecroft, Timothy D. Gauntner, Rituraj Upadhyay, Shang-Jui Wang, Yuanquan Yang , et al. · 2024

Metastatic renal cell carcinoma (mRCC) is a heterogenous disease with a variable clinical course. While therapies for treatment of this condition have progressed, they are not without toxicity. In some patients, active surveillance (AS) of…

Clinical features of prostate cancer by polygenic risk score Open

Christina Spears, Menglin Xu, Abigail B. Shoben, Shawn Dason, Amanda E. Toland , et al. · 2024

Natural History and Genomic Landscape of Chemotherapy-Resistant Muscle-Invasive Bladder Cancer Open

Andrew T. Lenis, Karissa Whiting, Vignesh Ravichandran, Jacob E. Tallman, Syed M. Alam , et al. · 2024

PURPOSE Patients with residual invasive bladder cancer after neoadjuvant chemotherapy (NAC) and radical cystectomy have a poor prognosis. Data on adjuvant therapy for these patients are conflicting. We sought to evaluate the natural histor…

Paradigm Shifting Research: Key Studies in Urologic Oncology Open

Shawn Dason, Cheryl T. Lee · 2024

Background Genitourinary malignancies have a substantial impact on men and women in the USA as they include three of the ten most common cancers (prostate, renal, and bladder). Other urinary tract cancers are less common (testis and penile…

Cytoreductive Nephrectomy Following Immunotherapy: Evolution, Pearls, and Pitfalls of Treatment Open

Laura E Davis, Adam Calaway, Eric A. Singer, Shawn Dason · 2024

Introduction: Renal Cell Carcinoma (RCC) is among the most frequently diagnosed malignancies in both genders with over 81,000 estimated cases in 2024. Despite increasing incidence of renal cell carcinomas <4 cm, up to 1/3 of patients diagn…

Intraoperative Embolization during Inferior Vena Cava Tumor Thrombectomy for Renal Cell Carcinoma Open

Samantha A. Roberts, Divyaam Satija, Henry Gold, Mina S. Makary, Jing G. Wang , et al. · 2023

Intraoperative tumor thrombus embolization is a potentially lethal complication during inferior vena cava (IVC) thrombectomy for renal cell carcinoma (RCC). Intraoperative embolization is uncommonly encountered because IVC thrombectomy sur…

Incorporating Stereotactic Ablative Radiotherapy into the Multidisciplinary Management of Renal Cell Carcinoma Open

Rohit K. Raj, Rituraj Upadhyay, Shang-Jui Wang, Eric A. Singer, Shawn Dason · 2023

Stereotactic ablative radiotherapy (SABR) has challenged the conventional wisdom surrounding the radioresistance of renal cell carcinoma (RCC). In the past decade, there has been a significant accumulation of clinical data to support the s…

Salvage lenvatinib/everolimus combination therapy after immune checkpoint inhibitor and VEGFR tyrosine kinase inhibitor for metastatic renal cell carcinoma Open

Christopher Kwok, Adam Khorasanchi, Sarah P. Psutka, Megan Hinkley, Shawn Dason , et al. · 2023

Background The optimal treatment for metastatic renal cell carcinoma (mRCC) patients who have progressed after both immune checkpoint inhibitor (ICI) and VEGFR tyrosine kinase inhibitor (TKI) remains uncertain. Lenvatinib and everolimus (L…

State of the Art: Multidisciplinary Management of Oligometastatic Renal Cell Carcinoma Open

Shawn Dason, Kristine Peregrino Lacuna, Raquibul Hannan, Eric A. Singer, Karie Runcie · 2023

Oligometastatic renal cell carcinoma (OM-RCC) refers to patients who have limited (typically up to 5) metastatic lesions. Although management principles may overlap, OM-RCC is distinguishable from oligoprogressive RCC, which describes prog…

Inferior vena cava thrombectomy for renal cell carcinoma: perioperative systemic therapy, cytoreductive nephrectomy, and complex cases Open

Shagnik Ray, Eric A. Singer, Shawn Dason · 2023

Genomic heterogeneity as a barrier to precision oncology in urothelial cancer Open

Timothy N. Clinton, Ziyu Chen, Hannah Wise, Andrew T. Lenis, Shweta S. Chavan , et al. · 2022

Incidental splenosis discovered during robotic assisted radical prostatectomy: A case report Open

Molly A. McNamara, Tasha Posid, Shawn Dason · 2022

Genomic Heterogeneity as a Barrier to Precision Oncology in Urothelial Cancer Open

Timothy N. Clinton, Ziyu Chen, Hannah Wise, Andrew T. Lenis, Shweta S. Chavan , et al. · 2022

Clinicopathologic Features of Scrotal Leiomyosarcoma: Single Institutional Experience of Ten Cases Open

Anne Taylor, Shawn Dason, Debra L. Zynger · 2022

Testicular Cancer Knowledge and Viewpoints of American Men Open

Sarah L. Beebe, Alicia Scimeca, Dinah Diab, Nathan C. Wong, Tasha Posid , et al. · 2021

American men do not feel knowledgeable about TC, have a favorable attitude toward TSE and want their doctor to discuss these topics. Shared decision making regarding TC screening is warranted given the low risk of harm and patient interest…

Correction: Protective effect of pharmacological castration on metabolic perturbations and cardiovascular disease in the hyperglycemic male ApoE−/−:Ins2+/Akita mouse model Open

Wilhelmina Duivenvoorden, Magda Naeim, Sarah Hopmans, Sadiya Yousef, Geoff H. Werstuck , et al. · 2021

Clinical utility of subclassifying positive surgical margins at radical prostatectomy Open

Shawn Dason, Emily Vertosick, Kazuma Udo, Daniel D. Sjoberg, Andrew J. Vickers , et al. · 2021

Objective To determine whether subclassification of positive surgical margins (PSMs) increases predictive ability for biochemical recurrence (BCR) and aids clinical decision‐making in patients undergoing radical prostatectomy. Patients and…

Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts Open

Kwanghee Kim, Wenhuo Hu, François Audenet, Nima Almassi, Aphrothiti J. Hanrahan , et al. · 2020

Trends in Management and Outcomes among Patients with Urothelial Carcinoma Undergoing Radical Cystectomy from 1995 to 2015: The Memorial Sloan Kettering Experience Open

Nima Almassi, K. Eugene, Emily Vertosick, Chun Huang, Nathan C. Wong , et al. · 2020

During a 21-year period outcomes after radical cystectomy at our institution improved significantly, as the probability of recurrence and cancer specific mortality decreased. Increasing use of neoadjuvant chemotherapy, rising pT0 rates, de…

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