Shawn Dormann
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View article: SHIPi improves hematologic recovery after chemotherapy
SHIPi improves hematologic recovery after chemotherapy Open
View article: Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment Open
View article: Obesity Control by Ship Inhibition Requires Pan-Paralog Inhibition and an Intact Eosinophil Compartment
Obesity Control by Ship Inhibition Requires Pan-Paralog Inhibition and an Intact Eosinophil Compartment Open
View article: Synthetic studies on the indane SHIP1 agonist AQX-1125
Synthetic studies on the indane SHIP1 agonist AQX-1125 Open
A new synthesis of the indane based SHIP1 agonist AQX-1125 was developed. Testing of AQX-1125 and some analogs provides information on the pharmacophore and bioactivity.
View article: Synthetic Studies on the Indane SHIP1 Agonist AQX-1125.
Synthetic Studies on the Indane SHIP1 Agonist AQX-1125. Open
A new synthetic route to the SHIP1 agonist AQX-1125 has been developed. This sequence utilizes a hydroxy-acid intermediate which allows for ready differentiation of the C6 and C7 positions. The role of the C17 alkene in the biological acti…
View article: Synthetic Studies on the Indane SHIP1 Agonist AQX-1125.
Synthetic Studies on the Indane SHIP1 Agonist AQX-1125. Open
A new synthetic route to the SHIP1 agonist AQX-1125 has been developed. This sequence utilizes a hydroxy-acid intermediate which allows for ready differentiation of the C6 and C7 positions. The role of the C17 alkene in the biological acti…
View article: Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2-Trichloroacetimidate
Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2-Trichloroacetimidate Open
2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate is an effective reagent for the formation of 2-trimethylsilylethyl esters without the need for an exogenous …
View article: Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate
Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate Open
2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate is an effective reagent for the formation of 2-trimethylsilylethyl esters without the need for an exogenous …
View article: Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate
Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate Open
2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate is an effective reagent for the formation of 2-trimethylsilylethyl esters without the need for an exogenous …
View article: Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment Open
Previously a small molecule SHIP inhibitor, K118, was shown to reverse high-fat diet induced obesity and improve blood glucose regulation in obese mice. K118 treatment was also found to increase the frequency and number of IL-4 producing e…
View article: Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment Open
Previously a small molecule SHIP inhibitor, K118, was shown to reverse high-fat diet induced obesity and improve blood glucose regulation in obese mice. K118 treatment was also found to increase the frequency and number of IL-4 producing e…
View article: Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis
Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis Open
We show here that both SHIP1 (Inpp5d) and its paralog SHIP2 (Inppl1) are expressed at protein level in microglia. To examine whether targeting of SHIP paralogs might influence microglial physiology and function, we tested the capacity of S…