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View article: D115. A Role for Tannic Acid in Restoring Elastogenesis Impaired by Common Aesthetic Agents
D115. A Role for Tannic Acid in Restoring Elastogenesis Impaired by Common Aesthetic Agents Open
PURPOSE: Aesthetic management of aging skin relies on precise extracellular matrix (ECM) homeostasis to maximize youthful resilience, fullness, and elasticity while mitigating risk of dermal fibroses. Elastogenesis is critical to this. Cur…
View article: Utilizing a Porcine Fat Grafting Model for Translational Research: Surgical Approach, Complications, and Expected Outcomes
Utilizing a Porcine Fat Grafting Model for Translational Research: Surgical Approach, Complications, and Expected Outcomes Open
Autologous fat grafting, or lipotransfer, is an important surgical approach to relocate adipose tissue within an individual to create volume. While used extensively in plastic and reconstructive surgery, significant drawbacks exist, includ…
View article: 100. Development Of An Ex Vivo Human Skin Perfusion Platform For Tumor Modeling
100. Development Of An Ex Vivo Human Skin Perfusion Platform For Tumor Modeling Open
Purpose: Despite recent advancements in cancer therapy, such as novel chemo- and immunotherapeutic agents, challenges persist in predicting patient responses. Preclinical testing is crucial, but current in-vivo experiments in genetically i…
View article: Fasciocutaneous Free Flap Transfer in a Novel Ovine Model: Translational Model for the Future of Microsurgery
Fasciocutaneous Free Flap Transfer in a Novel Ovine Model: Translational Model for the Future of Microsurgery Open
BACKGROUND: Free tissue transfer stands at the apex of the reconstructive ladder, however, despite decades of surgical innovation, free flaps remain limited by physiologic need for rapid and sustained reperfusion to maintain viability. Thi…
View article: Establishment of a Novel Explant Human Fasciocutaneous Flap Model to Understand the Mechanism of Radiation-Induced Skin Fibrosis
Establishment of a Novel Explant Human Fasciocutaneous Flap Model to Understand the Mechanism of Radiation-Induced Skin Fibrosis Open
INTRODUCTION: Radiation-induced skin fibrosis is one of the main adverse effects of radiation therapy for cancer treatment. Radiation fibrosis syndrome is caused by the overactivation of TGF-B that promotes fibroblast that induces collagen…
View article: 575 Single-stage Trilaminar Skin Reconstruction Following Full-Thickness Burn Injury
575 Single-stage Trilaminar Skin Reconstruction Following Full-Thickness Burn Injury Open
Introduction Complex burns are highly morbid injuries that can cause severe disfigurement and can be devastating to one’s quality of life and psychosocial well-being. Currently, there are no simple, single-stage procedures available for ex…
View article: 89. Topical Mineralocorticoid Inhibition Improves Epithelization in Full-thickness Healing Wounds
89. Topical Mineralocorticoid Inhibition Improves Epithelization in Full-thickness Healing Wounds Open
BACKGROUND: There is a delicate balance between physiologic healing and formation of unfavorable scars. Homeostasis between extracellular matrix (ECM) deposition and remodeling is maintained by an array of inter-connected signaling network…
View article: 12. Optimizing VD3 Timing and Dosing for Significantly Increasing Fat Graft Retention in a Swine Model
12. Optimizing VD3 Timing and Dosing for Significantly Increasing Fat Graft Retention in a Swine Model Open
PURPOSE: A major limitation of fat grafting is unpredictable retention. We previously demonstrated that bioactive Vitamin D (VD3), calcitriol, improves human fat graft retention in a xenograft mouse model, however, high dose calcitriol inc…
View article: 576 Pixel-Grafting and Negative-Pressure Moist Wound Chambers Improve Re-epithelization After Burn Injuries
576 Pixel-Grafting and Negative-Pressure Moist Wound Chambers Improve Re-epithelization After Burn Injuries Open
Introduction Complex burns are a challenge, often requiring prolonged reconstruction. Management requires consideration not only to the skin but to underlying structures and often requires staged-reconstruction and revision for increasingl…
View article: 96. Trilaminar Skin Reconstruction Following Full-thickness Burn Injury: A Single-staged Novel Approach
96. Trilaminar Skin Reconstruction Following Full-thickness Burn Injury: A Single-staged Novel Approach Open
PURPOSE: Thermal burns to the face or extremities are highly morbid injuries risking severe disfigurement, functional and psychosocial impairment. These injuries commonly require debridement and prolonged or staged reconstruction often wit…
View article: 24. Improving Re-epithelization after Burn Injuries: The Role of Pixel-grafting and Wet Wound Healing
24. Improving Re-epithelization after Burn Injuries: The Role of Pixel-grafting and Wet Wound Healing Open
PURPOSE: Complex facial and extremity burns present a difficult challenge affecting skin contour, mobility, and appearance. Management requires consideration not only to the skin, but to a patient's quality of life. Interventions often req…
View article: 94. Towards the Development and Optimization of a Swine Model for Adipose Engraftment
94. Towards the Development and Optimization of a Swine Model for Adipose Engraftment Open
PURPOSE: Current fat grafting small animal xenograft models have demonstrated success in human tissue survival. Yet are challenging given the limitations of scale and adipose structure between different species, the grafts' small size, and…
View article: 90. Tendon Recovery with Adipose-derived Stem Cells: A Novel Model
90. Tendon Recovery with Adipose-derived Stem Cells: A Novel Model Open
PURPOSE: Tendon injuries after trauma, or through use/disuse, or degeneration are among the most frequent musculoskeletal lesions treated by plastic surgeons. The healing process and inflammatory response following injury is critical to di…
View article: Biodegradable Nerve Guide with Glial Cell Line–Derived Neurotrophic Factor Improves Recovery After Facial Nerve Injury in Rats
Biodegradable Nerve Guide with Glial Cell Line–Derived Neurotrophic Factor Improves Recovery After Facial Nerve Injury in Rats Open
Background: Bioengineered nerve guides with glial cell line-derived neurotrophic factor (GDNF) support recovery after facial nerve injury by acting as regenerative scaffolds. Objective: To compare functional, electrophysiological, and hist…
View article: Evolution of the Push-2-Spin Fat Graft Processing Device: Enhancing Efficiency and Reducing Risk of Contamination
Evolution of the Push-2-Spin Fat Graft Processing Device: Enhancing Efficiency and Reducing Risk of Contamination Open
Background Small-volume fat graft efficiency is a critical determinant of the cost and material effectiveness of aesthetic fat grafting in the clinical space. Recent development of devices, such as the Push-2-Spin (P2S) system (Pittsburgh,…
View article: Platelet Rich Fibrin (PRF) Enhances Scar Resolution of High-tension Wounds in Rats
Platelet Rich Fibrin (PRF) Enhances Scar Resolution of High-tension Wounds in Rats Open
PURPOSE: Mechanical tension is a central determinant of the size, strength, and physiology of scars formed after cutaneous injury. (1) During post-traumatic proliferation and remodeling, supraphysiologic tension modulates cell signaling an…
View article: QS56. Thymosin Alpha 1 Enhances Macrophage Homing and Neutrophil Extracellular Trap Formation in Chronic Diabetic Wound
QS56. Thymosin Alpha 1 Enhances Macrophage Homing and Neutrophil Extracellular Trap Formation in Chronic Diabetic Wound Open
Purpose: Biofilm formation is a major impediment to chronic wound resolution. Activation of innate immune sentinel cells such as macrophages and dendritic cells through microbe recognition by toll-like receptors (TLRs) is critical in the c…
View article: QS34. Prostaglandin F2a Analog Focally Depletes Adipose Volume Without Concurrent Cytolysis
QS34. Prostaglandin F2a Analog Focally Depletes Adipose Volume Without Concurrent Cytolysis Open
Purpose: Adipose is one of the most mutable and commonly treated tissues in plastic surgery. Adipose tissue is often the thickest and most variable of the cutaneous layers and is a key contributor to smooth contour, feature, and expression…
View article: 83. Vitamin D3 Enhances Adipose Stromal Cell Bioenergetics Capacity Andproliferation Under Hypoxic Conditions and Improves Fat Grafting Outcomes
83. Vitamin D3 Enhances Adipose Stromal Cell Bioenergetics Capacity Andproliferation Under Hypoxic Conditions and Improves Fat Grafting Outcomes Open
Purpose: Reabsorption of autologous fat grafts is often unpredictable and thus volumetric results are not reliable. We have previously demonstrated the efficacy of vitamin D as a lipoprotectant to enhance adipose tissue survival in vitro, …
View article: QS47. Toll-like Receptor Agonism Upregulates Endothelial Populations and Supports Healing of Diabetic Wound
QS47. Toll-like Receptor Agonism Upregulates Endothelial Populations and Supports Healing of Diabetic Wound Open
Purpose: The diabetic wound microenvironment has several pathologic modifications which maintains its chronicity. The endothelium acts as a primary gatekeeper of the wound environment, which in its disease-related dysregulated state, engen…
View article: 103. Novel Nerve Guide Containing GDNF Microspheres Improves Recovery After Facial Nerve Injury in Rats
103. Novel Nerve Guide Containing GDNF Microspheres Improves Recovery After Facial Nerve Injury in Rats Open
Purpose: Injury to the facial nerve and the resulting facial nerve palsy lead to devastating functional, psychological, and cosmetic challenges. Rapid functional recovery after facial nerve injury is critical to prevent muscle atrophy and …
View article: QS59. Pulsed-release Dexamethasone-loaded Microspheres Mitigate Scar Contracture and Adhesions in Composite Tissue Burn Reconstruction
QS59. Pulsed-release Dexamethasone-loaded Microspheres Mitigate Scar Contracture and Adhesions in Composite Tissue Burn Reconstruction Open
Purpose: Soft-tissue loss after complex burns is devastating to quality of life, ability to work, and psychosocial well-being. These are disfiguring injuries requiring surgical management and are almost universally limited by contracture, …
View article: 36. Spironolactone Mitigates Fibrosis and Improves Healing of Burn Wounds
36. Spironolactone Mitigates Fibrosis and Improves Healing of Burn Wounds Open
Purpose: Adhesion, contracture, and the formation of disfiguring, hypertrophic scars remain some of the most recalcitrant problems in care of the burned patient. The central pathology driving fibrosis is an imbalance of extracellular matri…
View article: 53. Wound Edge Inversion Delays Healing and Contributes to Dystrophic Scar Formation in a Mouse Model
53. Wound Edge Inversion Delays Healing and Contributes to Dystrophic Scar Formation in a Mouse Model Open
Purpose: Management of dystrophic scars often requires surgical excision in the delayed periods as there are few reliable options to prophylax against the formation off dystrophic scars during physiologic or pathologic wound healing. This …
View article: P26. WOUND-EDGE INVERSION RESULTS IN THE RELIABLE, MECHANICAL FORMATION OF DYSTROPHIC SCARS IN MICE
P26. WOUND-EDGE INVERSION RESULTS IN THE RELIABLE, MECHANICAL FORMATION OF DYSTROPHIC SCARS IN MICE Open
PURPOSE: The nature of murine healing makes it poorly suited to the study of dystrophic scars. Murine wounds contract, epithelialize, and ultimately heal rapidly with limited appearance of injury. This can be overcome in the circumstances …
View article: 51. NOVEL NERVE GUIDE CONTAINING GDNF MICROSPHERES IMPROVES RECOVERY AFTER FACIAL NERVE INJURY IN RATS
51. NOVEL NERVE GUIDE CONTAINING GDNF MICROSPHERES IMPROVES RECOVERY AFTER FACIAL NERVE INJURY IN RATS Open
PURPOSE: Rapid functional recovery after facial nerve injury is critical to restoring expression. Tissue engineered nerve guides support enhanced recovery, acting as regenerative scaffolds. This can be improved by addition of exogenous neu…