Shawneequa Callier
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View article: Protocol for a modified Delphi study of ethical oversight of data science health research (DSHR)
Protocol for a modified Delphi study of ethical oversight of data science health research (DSHR) Open
Introduction The use of data science for health research produces complex ethical, legal and social challenges that traditional ethical oversight mechanisms struggle to address. In Nigeria, the current ethical guidelines were not designed …
View article: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database Open
Incomplete penetrance, or absence of disease phenotype in an individual with a disease-associated variant, is a major challenge in variant interpretation. Studying individuals with apparent incomplete penetrance can shed light on underlyin…
View article: Knowledge and Recommendations of Stakeholders regarding Ethical Oversight of Data Science Health Research: A qualitative study protocol. (Preprint)
Knowledge and Recommendations of Stakeholders regarding Ethical Oversight of Data Science Health Research: A qualitative study protocol. (Preprint) Open
View article: The Slippery Slope of Prenatal Testing for Social Traits
The Slippery Slope of Prenatal Testing for Social Traits Open
Bowman-Smart and colleagues argue for a framework to examine the ethical issues associated with genetic screening for non-medical traits in the context of non-invasive prenatal testing (NIPT). Such screening may be done by examining many g…
View article: Scanning the Horizon of Sociogenomics: An Assessment of the Development and Growth of Polygenic Scores for Social Traits
Scanning the Horizon of Sociogenomics: An Assessment of the Development and Growth of Polygenic Scores for Social Traits Open
Increasingly, researchers are leveraging social science survey data and genomic samples from millions of biobank participants to develop polygenic scores (PGSs) for social and behavioral traits. This article utilizes horizon scanning metho…
View article: P619: Risk factors for malignant hyperthermia crises and subsequent complications to inform model development for population newborn screening
P619: Risk factors for malignant hyperthermia crises and subsequent complications to inform model development for population newborn screening Open
View article: Ready, Set, Sort! A User-Guide to Card Sorts for Community-Engaged Empirical Bioethics.
Ready, Set, Sort! A User-Guide to Card Sorts for Community-Engaged Empirical Bioethics. Open
We demonstrate the fruitfulness of using card sort activities as an engagement method by detailing community consultation for ethical, legal, and social implications of sociogenomics. Readers are provided with a user-guide for card sort en…
View article: Ready, Set, Sort! A User-Guide to Card Sorts for Community-Engaged Empirical Bioethics
Ready, Set, Sort! A User-Guide to Card Sorts for Community-Engaged Empirical Bioethics Open
We demonstrate the fruitfulness of using card sort activities as an engagement method by detailing community consultation for ethical, legal, and social implications of sociogenomics. Readers are provided with a user-guide for card sort en…
View article: Native Hawaiian and Pacific Islander populations in genomic research
Native Hawaiian and Pacific Islander populations in genomic research Open
The role of genomic research and medicine in improving health continues to grow significantly, highlighting the need for increased equitable inclusion of diverse populations in genomics. Native Hawaiian and Pacific Islander (NHPI) communit…
View article: Analysis and Optimization of Equitable US Cancer Clinical Trial Center Access by Travel Time
Analysis and Optimization of Equitable US Cancer Clinical Trial Center Access by Travel Time Open
Importance Racially minoritized and socioeconomically disadvantaged populations are currently underrepresented in clinical trials. Data-driven, quantitative analyses and strategies are required to help address this inequity. Objective To s…
View article: Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects
Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects Open
Summary Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide association studies that elucidate genetic etiology of complex traits. However, individuals from diverse genetic ancestry groups are often excluded…
View article: The Legal Uncertainties of Sociogenomic Polygenic Scores.
The Legal Uncertainties of Sociogenomic Polygenic Scores. Open
Genomics may increasingly be used to predict associations with social traits through a new field called sociogenomics. This approach includes developing genetic 'scores' to identify associations with individuals' traits like educational at…
View article: Scanning the Horizon of Sociogenomics: An Assessment of the Development and Growth of Polygenic Scores for Social Traits <br>
Scanning the Horizon of Sociogenomics: An Assessment of the Development and Growth of Polygenic Scores for Social Traits Open
View article: <b>Anticipating Biopreservation Technologies that Pause Biological Time:</b> Building Governance & Coordination Across Applications
<b>Anticipating Biopreservation Technologies that Pause Biological Time:</b> Building Governance & Coordination Across Applications Open
Advanced biopreservation technologies using subzero approaches such as supercooling, partial freezing, and vitrification with reanimating techniques including nanoparticle infusion and laser rewarming are rapidly emerging as technologies w…
View article: Ethical Issues in Emerging Technologies to Extend the Viability of Biological Materials Across Time and Space
Ethical Issues in Emerging Technologies to Extend the Viability of Biological Materials Across Time and Space Open
This article presents a framework of ethical analysis for anticipatory evaluation of advanced biopreservation technologies and employs the framework illustratively in three domains. The framework features four clusters of general ethical c…
View article: The promise of data science for health research in Africa
The promise of data science for health research in Africa Open
Data science health research promises tremendous benefits for African populations, but its implementation is fraught with substantial ethical governance risks that could thwart the delivery of these anticipated benefits. We discuss emergin…
View article: The Slippery Slope of Prenatal Testing for Social Traits
The Slippery Slope of Prenatal Testing for Social Traits Open
Click to increase image sizeClick to decrease image sizeThis article refers to:Non-Invasive Prenatal Testing for “Non-Medical” Traits: Ensuring Consistency in Ethical Decision-Making DISCLOSURE STATEMENTNo potential conflict of interest wa…
View article: Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility
Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility Open
In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often‐ugly history of scientific attempts to understand the genetic cont…
View article: Wrestling with Public Input on an Ethical Analysis of Scientific Research
Wrestling with Public Input on an Ethical Analysis of Scientific Research Open
Bioethicists frequently call for empirical researchers to engage participants and community members in their research, but don't themselves typically engage community members in their normative research. In this article, we describe an eff…
View article: Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations
Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations Open
We present a new method, Multi-Ancestry Meta-Analysis (MAMA), which combines genome-wide association study (GWAS) summary statistics from multiple populations to produce new summary statistics for each population, identifying novel loci th…
View article: Complicated legacies: The human genome at 20
Complicated legacies: The human genome at 20 Open
Millions of people today have access to their personal genomic information. Direct-to-consumer services and integration with other “big data” increasingly commoditize what was rightly celebrated as a singular achievement in February 2001 w…
View article: Evaluating the promise of inclusion of African ancestry populations in genomics
Evaluating the promise of inclusion of African ancestry populations in genomics Open
View article: Diversity and Inclusion in Unregulated mHealth Research: Addressing the Risks
Diversity and Inclusion in Unregulated mHealth Research: Addressing the Risks Open
mHealth devices and applications, with their wide accessibility and ease of use, have the potential to address persistent inequities in biomedical research participation. Yet, while mHealth technologies may facilitate more inclusive resear…
View article: The Use of Racial Categories in Precision Medicine Research
The Use of Racial Categories in Precision Medicine Research Open
Scholars have shown that promoting diversity and inclusion in precision medicine research is important for ethical and scientific reasons. The processes for classifying the populations that enroll in biomedical research, however, are of…
View article: Attitudes and experiences regarding genetic research among persons of African descent
Attitudes and experiences regarding genetic research among persons of African descent Open
View article: Cardiologists' Perspectives on Race-Based Drug Labels and Prescribing Within the Context of Treating Heart Failure
Cardiologists' Perspectives on Race-Based Drug Labels and Prescribing Within the Context of Treating Heart Failure Open
Purpose: Cardiologists are known to consider patients' race when treating heart failure, but their views on the benefits and harms of this practice are largely undocumented. We set out to explore cardiologists' perspectives on the b…
View article: The Emergence of Genomic Research in Africa and New Frameworks for Equity in Biomedical Research
The Emergence of Genomic Research in Africa and New Frameworks for Equity in Biomedical Research Open
Individuals with African ancestry have the greatest genomic diversity in the world, yet they have been underrepresented in genomic research. To advance our understanding of human biology and our ability to trace human history, we must inc…
View article: 2084
2084 Open
OBJECTIVES/SPECIFIC AIMS: The purpose of this descriptive study is to explore knowledge, attitudes, and behaviors related to genetics and genetic research in a sample of persons of African descent. METHODS/STUDY POPULATION: Data were gener…
View article: Diversity and inclusion in genomic research: why the uneven progress?
Diversity and inclusion in genomic research: why the uneven progress? Open
View article: Will Precision Medicine Move Us beyond Race?
Will Precision Medicine Move Us beyond Race? Open
Although self-identified race may correlate with geographical ancestry, it does not predict an individual patient's genotype or drug response. Precision medicine may eventually replace the use of race in treatment decisions, but several hu…