Explanipedia

Factors influencing employment and absenteeism in working age people with multiple sclerosis Open

Ayelet Iron, Shay Menascu, Alon Kalron · 2025

To examine employment status amongst people with multiple sclerosis (pwMS) in Israel, identify predictors of employment status, and investigate factors contributing to absenteeism amongst employed individuals. This cross-sectional study in…

Disease Modifying Treatment Options in Very Early Onset Multiple Sclerosis—What Choice for Onset Under Age 5 Years? Open

Dana Craiu, Denisa Alice Dica, Cristina Pomeran, George Pescaru, Shay Menascu , et al. · 2025

Background/Objectives: Very early pediatric onset multiple sclerosis (POMS) is rare; clinical studies using disease modifying treatments (DMTs) have not been performed. Clinicians rely on studies performed at older age. This review resulte…

Subcortical brain volume changes linked to concern of falling in multiple sclerosis: a structural MRI study Open

Shay Menascu, Tali Drori, Alon Kalron · 2025

Introduction Concern of falling (CoF) affects approximately 50–60% of people with MS (pwMS) and is associated with physical and cognitive deficits. Despite its functional impact, CoF’s neuroanatomical correlates in pwMS are poorly understo…

Acquisition of susceptibility-sensitive sequences for central vein sign detection: A systematic review of MRI protocols Open

Ariel Kerpel, Sigal Tal, Shay Menascu, Daniela Noa Zohar, Gal Mandlavi , et al. · 2025

Sustained-release oral dalfampridine appears to have no impact on upper extremity function in people with multiple sclerosis: a randomized controlled trial Open

Shay Menascu, Lior Frid, Alon Kalron · 2025

Background: Upper limb dysfunction is common in people with multiple sclerosis (pwMS), significantly affecting daily activities and quality of life. While dalfampridine has shown efficacy in improving gait in pwMS, its impact on upper extr…

Machine learning–based prediction of disease progression in primary progressive multiple sclerosis Open

Michael Gurevich, Rina Zilkha‐Falb, J L Sherman, Maxime Usdin, Catarina Raposo , et al. · 2024

Primary progressive multiple sclerosis (PPMS) affects 10–15% of multiple sclerosis patients and presents significant variability in the rate of disability progression. Identifying key biological features and patients at higher risk for fas…

Unveiling the Psychological Consequences of Illness Perception in Pediatric Multiple Sclerosis: A Parent–Child Study Open

Roy Aloni, Gaya Asher, Amichai Ben-Ari, Shay Menascu · 2024

Background: Previous research has emphasized the significant role of illness perception in chronic diseases, including Multiple Sclerosis. Limited research has been conducted on exploring illness perception in Pediatric Onset Multiple Scle…

Deciphering the shift from benign to active relapsing-remitting multiple sclerosis: Insights into T regulatory cell dysfunction and apoptosis regulation Open

Anat Achiron, Rina Falb, Shay Menascu, David Magalashvili, Mathilda Mandel , et al. · 2024

The intricate gene regulatory networks that operate in switching-BMS are related to suppression of immune tolerance and aberrant apoptosis. These findings may lead to new therapeutic targets to prevent the escalation to active disease.

No immediate change in systemic cytokines following an eccentric muscle training session in people with multiple sclerosis Open

Yasmin Alt, Monique Wochatz, Anne Schraplau, Tilman Engel, Hadar Sharon , et al. · 2024

Background: Eccentric muscle contractions elicit distinct physiological responses, including modulation of the cytokine profile. Although relevant for rehabilitation, the effect of eccentric muscle training on the immune system has never b…

An Immersive Virtual Kitchen Training System for People with Multiple Sclerosis: A Development and Validation Study Open

Massimiliano Pau, Eleonora Cocco, Federico Arippa, Giulia Casu, Micaela Porta , et al. · 2023

Rehabilitation via virtual reality (VR) training tools allows repetitive, intensive, and task-specific practice in a controlled and safe environment. Our goal was to develop and validate a novel immersive VR system based on the practice of…

In-depth characterization of long-term humoral and cellular immune responses to COVID-19m-RNA vaccination in multiple sclerosis patients treated with teriflunomide or alemtuzumab Open

Anat Achiron, Mathilda Mandel, Sapir Dreyer-Alster, David Magalashvili, Shay Menascu , et al. · 2023

Intravenous immunoglobulin treatment during pregnancy and the post-partum period in women with multiple sclerosis: A prospective analysis Open

Shay Menascu, Michal Siegel-Kirshenbaum, Sapir Dreyer-Alster, Yehuda Warszawer, David Magalashvili , et al. · 2023

Background Relapsing-remitting multiple sclerosis (RRMS) affects predominantly young women within reproductive years. As an increased risk of relapses is known to occur during the post-partum period, it is important to consider treatment o…

Age-related blood transcriptional regulators affect disease progression in pediatric multiple sclerosis Open

Eitan Shavit, Shay Menascu, Anat Achiron, Michael Gurevich · 2022

<span>COVID</span>‐19 Alpha Variant (B.1.1.7): Humoral, memory B and T cells in <span>COVID</span>‐19 pediatric convalescents Open

Michael Gurevich, Rina Zilkha‐Falb, Polina Sonis, David Magalashvili, Mark Dolev , et al. · 2022

Background Studies of anti‐SARS‐CoV‐2 humoral and adaptive response in COVID‐19 non‐vaccinated pediatric convalescents are controversial and further evidence from the pediatric population are needed. Objectives To elucidate SARS‐CoV‐2 humo…

The Design, Development, and Testing of a Virtual Reality Device for Upper Limb Training in People With Multiple Sclerosis: Single-Center Feasibility Study Open

Alon Kalron, Lior Frid, Iliya Fonkatz, Shay Menascu, Mark Dolev , et al. · 2022

Background Multiple sclerosis (MS) is a common nontraumatic, neurological, disabling disease that often presents with upper limb dysfunction. Exercise training has resulted in improvement for patients; however, there can be a lack of compl…

Longitudinal relationships between disability and gait characteristics in people with MS Open

Sapir Dreyer-Alster, Shay Menascu, Mark Dolev, Uri Givon, David Magalashvili , et al. · 2022

Immune response to the third COVID-19 vaccine dose is related to lymphocyte count in multiple sclerosis patients treated with fingolimod Open

Anat Achiron, Mathilda Mandel, Michael Gurevich, Sapir Dreyer-Alster, David Magalashvili , et al. · 2022

COVID-19 vaccination in patients with multiple sclerosis: Safety and humoral efficacy of the third booster dose Open

Sapir Dreyer-Alster, Shay Menascu, Mathilda Mandel, Emanuel Shirbint, David Magalashvili , et al. · 2022

Motoric cognitive risk syndrome in people with multiple sclerosis: prevalence and correlations with disease-related factors Open

Sapir Dreyer-Alster, Shay Menascu, Roy Aloni, Uri Givon, Mark Dolev , et al. · 2022

Background: The motoric cognitive risk (MCR) syndrome, defined as the coexistence of slow gait and subjective cognitive complaints, has as yet not been researched in people with multiple sclerosis (pwMS). Objective: To examine the prevalen…

SARS‐CoV‐2 memory B and T cell profiles in mild COVID‐19 convalescent patients Open

Michael Gurevich, Rina Zilkha‐Falb, Polina Sonis, David Magalashvili, Shay Menascu , et al. · 2021

The study findings demonstrate the durability of adaptive cellular immunity at least for 7 months after SARS-CoV-2 infection, suggesting long-lasting protection.

Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a Open

Shay Menascu, Roy Aloni, Mark Dolev, David Magalashvili, Keren Gutman , et al. · 2021

Background Prevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of a 6 months computerized game training program on cognitive performance in MS patients with mild cognitive impairment. M…

Humoral immune response in multiple sclerosis patients following PfizerBNT162b2 COVID19 vaccination: Up to 6 months cross-sectional study Open

Anat Achiron, Mathilda Mandel, Sapir Dreyer-Alster, Gil Harari, Mark Dolev , et al. · 2021

Targeted Cognitive Game Training Enhances Cognitive Performance in Multiple Sclerosis Patients Treated With Interferon Beta 1-a Open

Shay Menascu, Roy Aloni, M. Dolev, David Magalashvili, Keren Gutman , et al. · 2021

BackgroundPrevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of short-term computerized game training on cognitive performance in MS patients with mild cognitive impairment.MethodsWe e…

COVID-19 vaccination in patients with multiple sclerosis: What we have learnt by February 2021 Open

Anat Achiron, Mark Dolev, Shay Menascu, Daniela-Noa Zohar, Sapir Dreyer-Alster , et al. · 2021

Background: Since vaccination against coronavirus disease 2019 (COVID-19) became available, risks related to vaccinating patients with multiple sclerosis (MS) need to be carefully assessed. Objective: Characterize safety and occurrence of …

Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis Open

Izhak Levi, Michael Gurevich, Gal Perlman, David Magalashvili, Shay Menascu , et al. · 2021

Multiple sclerosis (MS) is an immune-mediated disease whose precise etiology is unknown. Several studies found alterations in the microbiome of individuals with MS, but the mechanism by which it may affect MS is poorly understood. Here we …

Author response to: Correspondence to humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies Open

Anat Achiron, Mathilda Mandel, Sapir Dreyer-Alster, Gil Harari, David Magalashvili , et al. · 2021

Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies Open

Anat Achiron, Mathilda Mandel, Sapir Dreyer-Alster, Gil Harari, David Magalashvili , et al. · 2021

Background and Aims: The National Multiple Sclerosis Society and other expert organizations recommended that all patients with multiple sclerosis (MS) should be vaccinated against COVID-19. However, the effect of disease-modifying therapie…

Clinical and transcriptional recovery profiles in pediatric and adult multiple sclerosis patients Open

Shay Menascu, Yulia Khavkin, Rina Zilkha‐Falb, Mark Dolev, David Magalashvili , et al. · 2020

Objective To determine whether pediatric‐onset multiple sclerosis (POMS) and adults‐onset multiple sclerosis (AOMS) patients are different in initial disease severity and recovery and to investigate the associations with peripheral blood m…

Physical activity behavior in people with multiple sclerosis during the COVID-19 pandemic in Israel: Results of an online survey Open

Alon Kalron, Mark Dolev, Michal Greenberg‐Abrahami, Shay Menascu, Lior Frid , et al. · 2020

Cognitive function in multiple sclerosis: A long-term look on the bright side Open

Yermi Harel, Alon Kalron, Shay Menascu, David Magalashvili, Mark Dolev , et al. · 2019

The majority of DMD treated MS patients did not have cognitive decline that could impair their quality of life after disease of extended duration.

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