Shayne Mason
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View article: Non-targeted blood metabolomics of giraffe and white rhinoceros by 1 H nuclear magnetic resonance spectroscopy
Non-targeted blood metabolomics of giraffe and white rhinoceros by 1 H nuclear magnetic resonance spectroscopy Open
Background Blood metabolomics is used to study internal or external factors that may affect the cellular processes of a cell, tissue or organ. These factors affect species differently. Metabolome differences may differ in some sexes, but i…
View article: Potential biomarkers for tuberculous meningitis diagnosis using metabolomics and proteomics: a systematic review
Potential biomarkers for tuberculous meningitis diagnosis using metabolomics and proteomics: a systematic review Open
Tuberculosis (TB) is the leading cause of death from a single infectious agent, with approximately 1.2 million deaths reported in 2023. While TB primarily affects the lungs, it can also spread to other organs, where it is classified as ext…
View article: Paediatric CSF acylcarnitine reference ranges
Paediatric CSF acylcarnitine reference ranges Open
Acylcarnitines play a crucial role in energy metabolism pathways, primarily known for their involvement in the beta oxidation of fatty acids. However, their roles extend beyond mitochondrial transport; they also contribute to the synthesis…
View article: Characterizing tuberculous meningitis in a South African pediatric cohort using GCxGC-TOFMS metabolomics
Characterizing tuberculous meningitis in a South African pediatric cohort using GCxGC-TOFMS metabolomics Open
View article: Exploratory investigation of urinary alkanes and other volatile organic compounds in paediatric patients with tuberculous meningitis
Exploratory investigation of urinary alkanes and other volatile organic compounds in paediatric patients with tuberculous meningitis Open
Background Tuberculous meningitis (TBM) is a disease caused by Mycobacterium tuberculosis ( M. tb ) infection of the brain. Alkanes and other volatile organic compounds (VOCs) are biologically important metabolites that are used by infecti…
View article: CSF carnitine is a potential biomarker in paediatric tuberculous meningitis
CSF carnitine is a potential biomarker in paediatric tuberculous meningitis Open
View article: 1H nuclear magnetic resonance spectroscopy metabolomics of giraffe milk during mid- to late-lactation
1H nuclear magnetic resonance spectroscopy metabolomics of giraffe milk during mid- to late-lactation Open
Background: Dynamic changes in milk components during the end stages of lactation (involution) occur in all mammals. The time it takes to reach complete cessation may differ between taxa and species. The involution of cows, sheep, and goat…
View article: Assessing metabolic alterations and cancer biomarkers in athymic nude mice implanted with NSCLC spheroids
Assessing metabolic alterations and cancer biomarkers in athymic nude mice implanted with NSCLC spheroids Open
Background Preclinical rodent models are vital in cancer research, and enhancing their relevance reduces animal use. Aim The aim of this pilot study was to determine if A549 lung cancer spheroids implanted into athymic nude mice will chang…
View article: Retrospective Observational Study of CSF-Derived HIV-1 Tat and Vpr Amino Acid Sequences in a South African Pediatric Cohort with HIV Subtype C
Retrospective Observational Study of CSF-Derived HIV-1 Tat and Vpr Amino Acid Sequences in a South African Pediatric Cohort with HIV Subtype C Open
The human immunodeficiency virus (HIV-1) infiltrates the central nervous system (CNS) early in infection, leading to HIV-associated neurocognitive impairments, particularly pronounced in children who exhibit neurodevelopmental delay. Viral…
View article: Say hello to my little friend… micronutraceuticals in neuroenergetics, neuronal health, and neurodegenerative diseases
Say hello to my little friend… micronutraceuticals in neuroenergetics, neuronal health, and neurodegenerative diseases Open
Vitamins and minerals (micronutraceuticals) maintain good health. However, the specific effects of these micronutraceuticals on brain health are often overlooked, or not even known. In this review, an overview of the direct and indirect ef…
View article: Identifying the optimal dose of cannabidiol by intrabuccal administration in Kramnik ( <scp>C3HeB</scp> / <scp>FeJ</scp> ) mice
Identifying the optimal dose of cannabidiol by intrabuccal administration in Kramnik ( <span>C3HeB</span> / <span>FeJ</span> ) mice Open
Background Cannabidiol (CBD) has numerous therapeutic properties, and is used to treat neurological conditions, such as neuroinflammation. However, the optimal dose of CBD to penetrate the brain requires further investigation. The primary …
View article: Targeted metabolomics investigation of metabolic markers of Mycobacterium tuberculosis in the cerebrospinal fluid of paediatric patients with tuberculous meningitis
Targeted metabolomics investigation of metabolic markers of Mycobacterium tuberculosis in the cerebrospinal fluid of paediatric patients with tuberculous meningitis Open
Objective To investigate metabolic markers linked to Mycobacterium tuberculosis ( M . tb) in the cerebrospinal fluid (CSF) of a South African cohort of paediatric tuberculous meningitis (TBM). Methods Targeted proton magnetic resonance ( 1…
View article: Protocol for unified metabolomics and proteomics analysis of formalin-fixed paraffin-embedded tissue
Protocol for unified metabolomics and proteomics analysis of formalin-fixed paraffin-embedded tissue Open
The use of archival formalin-fixed paraffin-embedded (FFPE) tissue samples for biochemical analyses is problematic because of the formation of a Schiff base, leading to low protein and metabolite yields during analytical extractions. Here,…
View article: Comparative Effects of Efavirenz and Dolutegravir on Metabolomic and Inflammatory Profiles, and Platelet Activation of People Living with HIV: A Pilot Study
Comparative Effects of Efavirenz and Dolutegravir on Metabolomic and Inflammatory Profiles, and Platelet Activation of People Living with HIV: A Pilot Study Open
Antiretroviral therapy (ART) has reduced the mortality and morbidity associated with HIV. However, irrespective of treatment, people living with HIV remain at a higher risk of developing non-AIDS-associated diseases. In 2019, the World Hea…
View article: The diagnostic potential of urine in paediatric patients undergoing initial treatment for tuberculous meningitis
The diagnostic potential of urine in paediatric patients undergoing initial treatment for tuberculous meningitis Open
Tuberculous meningitis (TBM)—the extrapulmonary form of tuberculosis, is the most severe complication associated with tuberculosis, particularly in infants and children. The gold standard for the diagnosis of TBM requires cerebrospinal flu…
View article: LC–MS metabolomics and lipidomics in cerebrospinal fluid from viral and bacterial CNS infections: a review
LC–MS metabolomics and lipidomics in cerebrospinal fluid from viral and bacterial CNS infections: a review Open
There is compelling evidence that a dysregulated immune inflammatory response in neuroinfectious diseases results in modifications in metabolic processes and altered metabolites, directly or indirectly influencing lipid metabolism within t…
View article: Characterizing poorly controlled type 2 diabetes using 1H-NMR metabolomics
Characterizing poorly controlled type 2 diabetes using 1H-NMR metabolomics Open
Introduction The prevalence of type 2 diabetes has surged to epidemic proportions and despite treatment administration/adherence, some individuals experience poorly controlled diabetes. While existing literature explores metabolic changes …
View article: 1H-NMR metabolomics investigation of CSF from children with HIV reveals altered neuroenergetics due to persistent immune activation
1H-NMR metabolomics investigation of CSF from children with HIV reveals altered neuroenergetics due to persistent immune activation Open
Background HIV can invade the central nervous system (CNS) early during infection, invading perivascular macrophages and microglia, which, in turn, release viral particles and immune mediators that dysregulate all brain cell types. Consequ…
View article: A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders
A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders Open
Background The treatment of diverse diseases using plant-derived products is actively encouraged. In the past few years, cannabidiol (CBD) has emerged as a potent cannabis-derived drug capable of managing various debilitating neurological …
View article: Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric population
Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric population Open
Tuberculous meningitis (TBM) is a severe form of tuberculosis with high neuro-morbidity and mortality, especially among the paediatric population (aged ≤12 years). Little is known of the associated metabolic changes. This study aimed to id…
View article: Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment
Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment Open
Background The pathogenesis of tuberculous meningitis (TBM) involves infection by Mycobacterium tuberculosis in the meninges and brain. However, recent studies have shown that the immune response and inflammatory processes triggered by TBM…
View article: An exploratory investigation of the CSF metabolic profile of HIV in a South African paediatric cohort using GCxGC-TOF/MS
An exploratory investigation of the CSF metabolic profile of HIV in a South African paediatric cohort using GCxGC-TOF/MS Open
View article: Metabolic Alterations in Mothers Living with HIV and Their HIV-Exposed, Uninfected Infants
Metabolic Alterations in Mothers Living with HIV and Their HIV-Exposed, Uninfected Infants Open
HIV-exposed, uninfected (HEU) children present with suboptimal growth and a greater susceptibility to infection in early life when compared to HIV-unexposed, uninfected (HUU) children. The reasons for these findings are poorly understood. …
View article: The metabolic recovery of marathon runners: an untargeted 1H-NMR metabolomics perspective
The metabolic recovery of marathon runners: an untargeted 1H-NMR metabolomics perspective Open
Introduction: Extreme endurance events may result in numerous adverse metabolic, immunologic, and physiological perturbations that may diminish athletic performance and adversely affect the overall health status of an athlete, especially i…
View article: Phenylalanine metabolism and tetrahydrobiopterin bio-availability in COVID-19 and HIV
Phenylalanine metabolism and tetrahydrobiopterin bio-availability in COVID-19 and HIV Open
View article: 1H-NMR protocol for rapid diagnosis of purine and pyrimidine metabolic disorders in urine
1H-NMR protocol for rapid diagnosis of purine and pyrimidine metabolic disorders in urine Open
View article: Tuberculous Granuloma: Emerging Insights From Proteomics and Metabolomics
Tuberculous Granuloma: Emerging Insights From Proteomics and Metabolomics Open
Mycobacterium tuberculosis infection, which claims hundreds of thousands of lives each year, is typically characterized by the formation of tuberculous granulomas — the histopathological hallmark of tuberculosis (TB). Our knowledge of gran…
View article: Immune Dysregulation Is Associated with Neurodevelopment and Neurocognitive Performance in HIV Pediatric Populations—A Scoping Review
Immune Dysregulation Is Associated with Neurodevelopment and Neurocognitive Performance in HIV Pediatric Populations—A Scoping Review Open
HIV-1 is known for its complex interaction with the dysregulated immune system and is responsible for the development of neurocognitive deficits and neurodevelopmental delays in pediatric HIV populations. Considering that HIV-1-induced imm…
View article: Sub-Cellular Metabolomics Contributes Mitochondria-Specific Metabolic Insights to a Mouse Model of Leigh Syndrome
Sub-Cellular Metabolomics Contributes Mitochondria-Specific Metabolic Insights to a Mouse Model of Leigh Syndrome Open
Direct injury of mitochondrial respiratory chain (RC) complex I by Ndufs4 subunit mutations results in complex I deficiency (CID) and a progressive encephalomyopathy, known as Leigh syndrome. While mitochondrial, cytosolic and multi-organe…
View article: CSF Metabolomics of Tuberculous Meningitis: A Review
CSF Metabolomics of Tuberculous Meningitis: A Review Open
From the World Health Organization’s global TB report for 2020, it is estimated that in 2019 at least 80,000 children (a particularly vulnerable population) developed tuberculous meningitis (TBM)—an invariably fatal disease if untreated—al…