Shea T. Meyer
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View article: SHIPi improves hematologic recovery after chemotherapy
SHIPi improves hematologic recovery after chemotherapy Open
View article: Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators
Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators Open
The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of interest in the treatment of inflammatory disorders. Recent results also indicate that SHIP1 promotes phagolysosomal …
View article: Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment Open
View article: N1-Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents
N1-Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents Open
Inhibition of phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP) with small molecule inhibitors leads to apoptosis in tumor cells. Inhibitors that target both SHIP1 and SHIP2 (pan-SHIP1/2 inhibitors) may have benefits in these a…
View article: LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism
LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism Open
Humans homozygous for inactivating LRBA (lipopolysaccharide (LPS)-responsive beige-like anchor) mutations or with compound heterozygous mutations exhibit a spectrum of immune-related pathologies including inflammatory bowel disease (IBD). …
View article: Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia
Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia Open
View article: Obesity Control by Ship Inhibition Requires Pan-Paralog Inhibition and an Intact Eosinophil Compartment
Obesity Control by Ship Inhibition Requires Pan-Paralog Inhibition and an Intact Eosinophil Compartment Open
View article: Targeting SHIP1 and SHIP2 in Cancer
Targeting SHIP1 and SHIP2 in Cancer Open
Membrane-anchored and soluble inositol phospholipid species are critical mediators of intracellular cell signaling cascades. Alterations in their normal production or degradation are implicated in the pathology of a number of disorders inc…
View article: Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2-Trichloroacetimidate
Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2-Trichloroacetimidate Open
2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate is an effective reagent for the formation of 2-trimethylsilylethyl esters without the need for an exogenous …
View article: Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate
Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate Open
2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate is an effective reagent for the formation of 2-trimethylsilylethyl esters without the need for an exogenous …
View article: Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate
Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2- Trichloroacetimidate Open
2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate is an effective reagent for the formation of 2-trimethylsilylethyl esters without the need for an exogenous …
View article: Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment Open
Previously a small molecule SHIP inhibitor, K118, was shown to reverse high-fat diet induced obesity and improve blood glucose regulation in obese mice. K118 treatment was also found to increase the frequency and number of IL-4 producing e…
View article: Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment Open
Previously a small molecule SHIP inhibitor, K118, was shown to reverse high-fat diet induced obesity and improve blood glucose regulation in obese mice. K118 treatment was also found to increase the frequency and number of IL-4 producing e…