Sheon Mary
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View article: Salt-Induced Vascular Damage in Hypertension Involves Redox Activation of PARP/TRPM2 Signaling and Inflammasome Assembly
Salt-Induced Vascular Damage in Hypertension Involves Redox Activation of PARP/TRPM2 Signaling and Inflammasome Assembly Open
BACKGROUND Excess sodium intake induces vascular dysfunction. Molecular mechanisms underlying this are unclear. Here we investigated the role of reactive oxygen species (ROS), Ca2+ signaling and inflammation in salt-induced vascular injury…
View article: Prediction of COVID-19: WAOptimizer Ensemble Classification Model with Clinical Parameters
Prediction of COVID-19: WAOptimizer Ensemble Classification Model with Clinical Parameters Open
Introduction: Machine learning-based prediction systems have enormous potential to enhance clinical utility in diagnosing COVID-19. Machine learning can address prediction challenges in the healthcare sector by improving diagnostic efficie…
View article: Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer
Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer Open
Breast cancer affects 1/8 of women throughout their lifetimes, with over 90% of cancer deaths being caused by metastasis. However, metastasis poses unique challenges to research, as complex changes in the microenvironment in different meta…
View article: Insights into Uromodulin and Blood Pressure
Insights into Uromodulin and Blood Pressure Open
Purpose of Review We review the role of uromodulin, a protein exclusively expressed in the kidney, in blood pressure regulation and hypertension. Recent Findings The last few years have seen a shift of focus from genetic association to men…
View article: Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension
Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension Open
Background Pregnancy involves major adaptations in renal haemodynamics, tubular, and endocrine functions. Hypertensive disorders of pregnancy are a leading cause of maternal mortality and morbidity. Uromodulin is a nephron-derived protein …
View article: Urinary Peptidomics and Pulse Wave Velocity: The African-PREDICT Study
Urinary Peptidomics and Pulse Wave Velocity: The African-PREDICT Study Open
Increased arterial stiffness is related to early vascular aging and is an independent predictor for cardiovascular disease and mortality. Molecular mechanisms underlying increased arterial stiffness are largely unexplored, especially at th…
View article: Identifying a urinary peptidomics profile for hypertension in young adults: The African‐PREDICT study
Identifying a urinary peptidomics profile for hypertension in young adults: The African‐PREDICT study Open
Hypertension is one of the most important and complex risk factors for cardiovascular diseases (CVDs). By using urinary peptidomics analyses, we aimed to identify peptides associated with hypertension, building a framework for future resea…
View article: Skin-specific mechanisms of body fluid regulation in hypertension
Skin-specific mechanisms of body fluid regulation in hypertension Open
Increasing evidence suggests excess skin Na+ accumulation in hypertension; however, the role of skin-specific mechanisms of local Na+/water regulation remains unclear. We investigated the association between measures of sweat and trans-epi…
View article: Role of Uromodulin in Salt-Sensitive Hypertension
Role of Uromodulin in Salt-Sensitive Hypertension Open
The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in kidney and cardiovascular research. Genome-wide association studies discovered variants of uromodulin that are associated with chronic kidney diseas…
View article: Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7 Open
The bifunctional cation channel/kinase TrpM7 is ubiquitously expressed and regulates embryonic development and pathogenesis of several common diseases. The TrpM7 integral membrane ion channel domain regulates transmembrane movement of diva…
View article: Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats
Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats Open
Uromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have demonstrated an association between UMOD risk variants and hypertension.…
View article: Preexisting hypertension and pregnancy-induced hypertension reveal molecular differences in placental proteome in rodents
Preexisting hypertension and pregnancy-induced hypertension reveal molecular differences in placental proteome in rodents Open
Preexisting or new onset of hypertension affects pregnancy and is one of the leading causes of maternal and fetal morbidity and mortality. In certain cases, it also leads to long-term maternal cardiovascular complications. The placenta is …
View article: Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension
Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension Open
Hypertension is a significant risk factor for cardiovascular disease and mortality worldwide. The kidney is a major regulator of blood pressure and electrolyte homeostasis, with monogenic disorders indicating a link between abnormal ion tr…
View article: Supplemental file_placental proteomeV2_SM20201227.docx
Supplemental file_placental proteomeV2_SM20201227.docx Open
This file consists of supplemental data from the manuscript titled "Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents"Authored by Sheon Mary1, Heather Small1, Florian…
View article: Supplemental file_placental proteomeV2_SM20201227.docx
Supplemental file_placental proteomeV2_SM20201227.docx Open
This file consists of supplemental data from the manuscript titled "Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents"Authored by Sheon Mary1, Heather Small1, Florian…
View article: Supplemental file_placental proteomeV2_SM20201227.docx
Supplemental file_placental proteomeV2_SM20201227.docx Open
This file consists of supplemental data from the manuscript titled "Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents"Authored by Sheon Mary1, Heather Small1, Florian…
View article: Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
Tissue sodium excess is not hypertonic and reflects extracellular volume expansion Open
Our understanding of Na + homeostasis has recently been reshaped by the notion of skin as a depot for Na + accumulation in multiple cardiovascular diseases and risk factors. The proposed water-independent nature of tissue Na + could induce…
View article: High sodium intake, glomerular hyperfiltration, and protein catabolism in patients with essential hypertension
High sodium intake, glomerular hyperfiltration, and protein catabolism in patients with essential hypertension Open
Aims A blood pressure (BP)-independent metabolic shift towards a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to inves…
View article: Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp
Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp Open
Premenopausal women are relatively protected from developing hypertension compared to men. Perivascular adipose tissue (PVAT) has been shown to mediate vasoactive effects; however, a sex-dependent difference in PVAT function in the setting…
View article: Is there a role for proteomics in diabetic renal disease?
Is there a role for proteomics in diabetic renal disease? Open
No abstract available.
View article: Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat
Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat Open
The kidney is centrally involved in blood pressure regulation and undergoes extensive changes during pregnancy. Hypertension during pregnancy may result in an altered urinary peptidome that could be used to indicate new targets of therapeu…
View article: MOESM3 of Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women
MOESM3 of Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women Open
Additional file 3: Table S2. Western Blot normalization calculations.
View article: MOESM2 of Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women
MOESM2 of Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women Open
Additional file 2: Table S1. PLGS protein identification data including MW, pI, the number of peptides, PLGS score, coverage, modifications, MS/MS fragmentation, and sequence of peptides.