Sheena Dass
YOU?
Author Swipe
View article: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes
PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes Open
Invasion of erythrocytes by members of the Plasmodium genus is an essential step of the parasite lifecycle, orchestrated by numerous host-parasite interactions. In P. falciparum Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms the ess…
View article: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of <i>Plasmodium</i> species into erythrocytes
PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of <i>Plasmodium</i> species into erythrocytes Open
Summary Invasion of erythrocytes by members of the Plasmodium genus is an essential step of the parasite lifecycle, orchestrated by numerous host-parasite interactions. In P. falciparum Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms…
View article: The acyl-CoA synthetase <i>Tg</i> ACS1 allows neutral lipid metabolism and extracellular motility in <i>Toxoplasma gondii</i> through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions
The acyl-CoA synthetase <i>Tg</i> ACS1 allows neutral lipid metabolism and extracellular motility in <i>Toxoplasma gondii</i> through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions Open
Apicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have major health and economic burdens. These unicellular pathogens are obligate intracellular parasites that heavily depend on lipid metabolism for the surv…
View article: Development of a<i>Plasmodium vivax</i>biobank for functional<i>ex vivo</i>assays
Development of a<i>Plasmodium vivax</i>biobank for functional<i>ex vivo</i>assays Open
Background Plasmodium vivax is the second most prevalent cause of malaria yet remains challenging to study due to the lack of a continuous in vitro culture system, highlighting the need to establish a biobank of clinical isolates with mult…
View article: Additional file 2 of Development of a Plasmodium vivax biobank for functional ex vivo assays
Additional file 2 of Development of a Plasmodium vivax biobank for functional ex vivo assays Open
Additional file 2. Data for figures 1–5.
View article: The structure of a <i>Plasmodium vivax</i> Tryptophan Rich Antigen suggests a lipid binding function for a pan-<i>Plasmodium</i> multi-gene family
The structure of a <i>Plasmodium vivax</i> Tryptophan Rich Antigen suggests a lipid binding function for a pan-<i>Plasmodium</i> multi-gene family Open
Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family in all Plasmodium species, significantly expanded in P. vivax , but their function is not currently known. We show that multiple P. vivax TRAgs are expressed on the merozo…
View article: The flexibility of Apicomplexa parasites in lipid metabolism
The flexibility of Apicomplexa parasites in lipid metabolism Open
Apicomplexa are obligate intracellular parasites responsible for major human infectious diseases such as toxoplasmosis and malaria, which pose social and economic burdens around the world. To survive and propagate, these parasites need to …
View article: Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage Open
Apicomplexa are obligate intracellular parasites responsible for major human diseases. Their intracellular survival relies on intense lipid synthesis, which fuels membrane biogenesis. Parasite lipids are generated as an essential combinati…
View article: Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling
Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling Open
Apicomplexan parasites are unicellular eukaryotes responsible for major human diseases including malaria and toxoplasmosis. Apicomplexan parasites must obtain and combine lipids both from host cell scavenging and de novo synthesis to maint…
View article: Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches
Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches Open
Dinitroanilines are chemical compounds with high selectivity for plant cell α-tubulin in which they promote microtubule depolymerization. They target α-tubulin regions that have diverged over evolution and show no effect on non-photosynthe…
View article: Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages
Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages Open
Apicomplexan parasites are pathogens responsible for major human diseases such as toxoplasmosis caused by Toxoplasma gondii and malaria caused by Plasmodium spp. Throughout their intracellular division cycle, the parasites require vast and…
View article: Basigin Interacts with Plasmodium vivax Tryptophan-rich Antigen PvTRAg38 as a Second Erythrocyte Receptor to Promote Parasite Growth
Basigin Interacts with Plasmodium vivax Tryptophan-rich Antigen PvTRAg38 as a Second Erythrocyte Receptor to Promote Parasite Growth Open
Elucidating the molecular mechanisms of the host-parasite interaction during red cell invasion by Plasmodium is important for developing newer antimalarial therapeutics. Recently, we have characterized a Plasmodium vivax tryptophan-rich an…