Summya Rashid
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View article: Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo Open
Background Chemotherapy-induced organ toxicity is one of the most common toxic effects of 5-fluorouracil (5-FU) in cancer patients. Therefore, new strategies are needed to prevent chemotherapy-induced kidney toxicity. Thymoquinone (TQ), a …
View article: Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders
Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders Open
Identifying novel biomarkers is a reliable approach to predict and diagnose human diseases as well as manage individual responses to therapeutic drugs. Heat shock proteins (HSPs) are molecular chaperones that play a major role in maintaini…
View article: RETRACTED: Rehman et al. Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats. Biology 2020, 9, 302
RETRACTED: Rehman et al. Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats. Biology 2020, 9, 302 Open
The journal retracts the article, “Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats” [...]
View article: Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies
Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies Open
Green tea has garnered increasing attention across age groups due to its numerous health benefits, largely attributed to Epigallocatechin 3-gallate (EGCG), its key polyphenol. EGCG exhibits a wide spectrum of biological activities, includi…
View article: Nutritional, Nutraceutical, and Medicinal Potential of <i>Cantharellus cibarius</i> Fr.: A Comprehensive Review
Nutritional, Nutraceutical, and Medicinal Potential of <i>Cantharellus cibarius</i> Fr.: A Comprehensive Review Open
Mushrooms are considered as nutraceutical foods that can effectively prevent diseases such as cancer and other serious life‐threatening conditions include neurodegeneration, hypertension, diabetes, and hypercholesterolemia. The Cantharellu…
View article: Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions
Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions Open
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several…
View article: Recent Review on Biological Barriers and Host–Material Interfaces in Precision Drug Delivery: Advancement in Biomaterial Engineering for Better Treatment Therapies
Recent Review on Biological Barriers and Host–Material Interfaces in Precision Drug Delivery: Advancement in Biomaterial Engineering for Better Treatment Therapies Open
Preclinical and clinical studies have demonstrated that precision therapy has a broad variety of treatment applications, making it an interesting research topic with exciting potential in numerous sectors. However, major obstacles, such as…
View article: Green synthesized silver nanoparticles of <i>Terminalia bellirica</i> leaves extract: synthesis, characterization, <i>in-silico</i> studies, and antimalarial activity
Green synthesized silver nanoparticles of <i>Terminalia bellirica</i> leaves extract: synthesis, characterization, <i>in-silico</i> studies, and antimalarial activity Open
Malaria is a mosquito-borne infectious disease that is caused by the Plasmodium parasite. Most of the available medication are losing their efficacy. Therefore, it is crucial to create fresh leads to combat malaria. Green silver nanopartic…
View article: AI illuminates paths in oral cancer: transformative insights, diagnostic precision, and personalized strategies
AI illuminates paths in oral cancer: transformative insights, diagnostic precision, and personalized strategies Open
Oral cancer retains one of the lowest survival rates worldwide, despite recent therapeutic advancements signifying a tenacious challenge in healthcare. Artificial intelligence exhibits noteworthy potential in escalating diagnostic and trea…
View article: Exploring progress in iron supplement formulation approaches for treating iron deficiency anemia through bibliometric and thematic analysis
Exploring progress in iron supplement formulation approaches for treating iron deficiency anemia through bibliometric and thematic analysis Open
Anemia is a severe health issue that affects around one-third of the global population. Therefore, the present study aims to conduct a bibliometric analysis to investigate the research trends regarding advancements on iron formulations in …
View article: Effect of Sustainable Pretreatments on the Nutritional and Functionality of Chickpea Protein: Implication for Innovative Food Product Development
Effect of Sustainable Pretreatments on the Nutritional and Functionality of Chickpea Protein: Implication for Innovative Food Product Development Open
Chickpea is a globally cultivated legume, rich in vitamins, protein, carbohydrates, polyphenols, fatty acids, fibers, and flavonoids. Despite its nutritional benefits, chickpeas contain antinutritional factors that can hinder nutrient abso…
View article: QSAR and docking based lead optimization of nitrogen heterocycles for enhanced prostaglandin EP2 receptor agonistic potency
QSAR and docking based lead optimization of nitrogen heterocycles for enhanced prostaglandin EP2 receptor agonistic potency Open
In the existing effort, a dataset of 309 experimentally screened molecules for in vitro (Ki) agonist potential for Prostaglandin E2 (PGE2) receptor 2 subtype (EP2), which is a metabolite of arachidonic acid that binds with and regulates ce…
View article: Application of in-silico drug discovery techniques to discover a novel hit for target-specific inhibition of SARS-CoV-2 Mpro’s revealed allosteric binding with MAO-B receptor: A theoretical study to find a cure for post-covid neurological disorder
Application of in-silico drug discovery techniques to discover a novel hit for target-specific inhibition of SARS-CoV-2 Mpro’s revealed allosteric binding with MAO-B receptor: A theoretical study to find a cure for post-covid neurological disorder Open
Several studies have revealed that SARS-CoV-2 damages brain function and produces significant neurological disability. The SARS-CoV-2 coronavirus, which causes COVID-19, may infect the heart, kidneys, and brain. Recent research suggests th…
View article: Nigella sativa Averts 5-Fluorouracil Induced Kidney Injury via Targeting Redox Imbalance and MAPK Pathway
Nigella sativa Averts 5-Fluorouracil Induced Kidney Injury via Targeting Redox Imbalance and MAPK Pathway Open
Introduction: Chemotherapy-induced organ toxicities are the most frequent toxic manifestation of 5-fluorouracil (5-Fu) action in cancer patients. Hence, new approaches are required to deter chemotherapy-induced kidney toxicity. Nigella sat…
View article: A drug design strategy based on molecular docking and molecular dynamics simulations applied to development of inhibitor against triple-negative breast cancer by Scutellarein derivatives
A drug design strategy based on molecular docking and molecular dynamics simulations applied to development of inhibitor against triple-negative breast cancer by Scutellarein derivatives Open
Triple-negative breast cancer (TNBC), accounting for 10–15% of all breast malignancies, is more prevalent in women under 40, particularly in those of African descent or carrying the BRCA1 mutation. TNBC is characterized by the absence of e…
View article: Mechanistic QSAR analysis to predict the binding affinity of diverse heterocycles as selective cannabinoid 2 receptor inhibitor
Mechanistic QSAR analysis to predict the binding affinity of diverse heterocycles as selective cannabinoid 2 receptor inhibitor Open
CB2R are fascinating targets for neuropathic pain and mood disorders because of their improved biological characteristics. Experimental data on 1296 cannabinoid-2 receptor inhibitors with different structural properties were used to develo…
View article: Insights on in-silico approaches for identifying potential bioactive inhibitors for TNF-α and IL-6 proteins associated with rheumatoid arthritis
Insights on in-silico approaches for identifying potential bioactive inhibitors for TNF-α and IL-6 proteins associated with rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a chronic immunocompromised disorder that primarily affects joints thereby leading to synovial inflammation, pain, stiffness, stress, and affecting the quality of life. The present study aimed to determine and …
View article: Inhibition of Autophagy and the Cytoprotective Role of Smac Mimetic against ROS-Induced Cancer: A Potential Therapeutic Strategy in Relapse and Chemoresistance Cases in Breast Cancer
Inhibition of Autophagy and the Cytoprotective Role of Smac Mimetic against ROS-Induced Cancer: A Potential Therapeutic Strategy in Relapse and Chemoresistance Cases in Breast Cancer Open
With more than a million deaths each year, breast cancer is the top cause of death in women. Around 70% of breast cancers are hormonally responsive. Although several therapeutic options exist, cancer resistance and recurrence render them i…
View article: Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications
Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications Open
Cellular signaling pathways involved in the maintenance of the equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited in the prevention and treatment of cancer. Epigallocatechin-3-gallat…
View article: Investigating the role of Kinesin family in lung adenocarcinoma via integrated bioinformatics approach
Investigating the role of Kinesin family in lung adenocarcinoma via integrated bioinformatics approach Open
Lung cancer is the leading cause of mortality from cancer worldwide. Lung adenocarcinoma (LUAD) is a type of non-small cell lung cancer (NSCLC) with highest prevalence. Kinesins a class of motor proteins are shown to be involved in carcino…
View article: Effects of gut microbiota on neurodegenerative diseases
Effects of gut microbiota on neurodegenerative diseases Open
A progressive degradation of the brain’s structure and function, which results in a reduction in cognitive and motor skills, characterizes neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotro…
View article: Formulation of pH-responsive highly swellable hydrogel scaffolds for controlled release of tramadol HCl: characterization and biocompatibility evaluation
Formulation of pH-responsive highly swellable hydrogel scaffolds for controlled release of tramadol HCl: characterization and biocompatibility evaluation Open
Introduction: The objective of current project was to formulate a system for controlled delivery of Tramadol HCl (TRD), an opioid analgesic used in the treatment of moderate to severe pain. Methods: For this purpose, a pH responsive AvT-co…
View article: Elucidation of novel compounds and epitope-based peptide vaccine design against C30 endopeptidase regions of SARS-CoV-2 using immunoinformatics approaches
Elucidation of novel compounds and epitope-based peptide vaccine design against C30 endopeptidase regions of SARS-CoV-2 using immunoinformatics approaches Open
There has been progressive improvement in immunoinformatics approaches for epitope-based peptide design. Computational-based immune-informatics approaches were applied to identify the epitopes of SARS-CoV-2 to develop vaccines. The accessi…
View article: Recent Advances in Molecular Mechanisms of Cancer Immunotherapy
Recent Advances in Molecular Mechanisms of Cancer Immunotherapy Open
Cancer is among the current leading causes of death worldwide, despite the novel advances that have been made toward its treatment, it is still considered a major public health concern. Considering both the serious impact of cancer on publ…
View article: Understanding the mechanistic potential of plant based phytochemicals in management of postmenopausal osteoporosis
Understanding the mechanistic potential of plant based phytochemicals in management of postmenopausal osteoporosis Open
Postmenopausal osteoporosis, an epidemic disorder is defined as a loss in bone mineral density and a greater possibility of fractures in older women. It is a multifactorial disease under the control of various genetic, hormonal, and enviro…
View article: Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits
Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits Open
α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective, antimicrobial, antioxidant, and anti-inflammatory properties, and induces apoptosi…