Explanipedia

JC polyomavirus neuroinvasion across the blood-brain barrier: Current understanding and emerging perspectives Open

Wenqing Yuan, Bethany A. O’Hara, Sheila A. Haley, Walter J. Atwood · 2025

JC Polyomavirus (JCPyV) is the causative agent of progressive multifocal leukoencephalopathy (PML), an often-fatal demyelinating disease. Unfortunately, a diagnosis of PML occurs only after patients have suffered irreversible neuropatholog…

Therapeutic potential of flavonols in the treatment of JCPyV Open

Evan MacLure, Kaitlin Garabian, Bethany A. O’Hara, Wenqing Yuan, Jacob Kaiserman , et al. · 2025

JC polyomavirus (JCPyV) is a double-stranded DNA virus that causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease with a high rate of morbidity and mortality. There are limited treatment options for patients diag…

Neurovascular pericytes are susceptible to infection by JC polyomavirus Open

Bethany A. O’Hara, Kaitlin Garabian, Wenqing Yuan, Walter J. Atwood, Sheila A. Haley · 2025

Progressive multifocal leukoencephalopathy (PML), an often-fatal neurodegenerative disease, is caused by the neuroinvasive polyomavirus JCPyV. Peripheral organs, including the kidney, are the site of lifelong persistent infections that are…

The microvascular endothelium of the blood-brain barrier is highly restrictive to JC Polyomavirus neuroinvasion Open

Avraham S. Lukacher, Bethany A. O’Hara, Wenqing Yuan, Kaitlin Garabian, Jacob Kaiserman , et al. · 2025

JC Polyomavirus is the causative agent of progressive multifocal leukoencephalopathy (PML), an often-fatal demyelinating disease. Unfortunately, a diagnosis of PML occurs only after patients have suffered irreversible neuropathologies. The…

Highly restrictive and directional penetration of the blood cerebral spinal fluid barrier by JCPyV Open

Bethany A. O’Hara, Avraham S. Lukacher, Kaitlin Garabian, Jacob Kaiserman, Evan MacLure , et al. · 2024

The human polyomavirus JCPyV is an opportunistic pathogen that infects greater than 60% of the world’s population. The virus establishes a persistent and asymptomatic infection in the urogenital system but can cause a fatal demyelinating d…

JCPyV infection of primary choroid plexus epithelial cells reduces expression of critical junctional proteins and increases expression of barrier disrupting inflammatory cytokines Open

Sheila A. Haley, Bethany A. O’Hara, Christoph Schorl, Walter J. Atwood · 2024

The human polyomavirus, JCPyV, establishes a lifelong persistent infection in the peripheral organs of a majority of the human population worldwide. Patients who are immunocompromised due to underlying infections, cancer, or to immunomodul…

An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy Open

Jacob Kaiserman, Bethany A. O’Hara, Sheila A. Haley, Walter J. Atwood · 2023

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease caused by infection with JC Polyomavirus (JCPyV). Despite the identification of the disease and isolation of the causative pathogen over fifty years ago, no a…

The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway Open

Jacob Kaiserman, Bethany A. O’Hara, Kaitlin Garabian, Avraham Lukacher, Sheila A. Haley , et al. · 2023

Human polyomaviruses, such as JCPyV and BKPyV, cause significant morbidity and mortality in immunocompromised or immunomodulated patients. There are no treatments for polyomavirus-induced diseases other than restoration of immune function.…

Biogenesis of JC polyomavirus associated extracellular vesicles Open

Jenna Morris‐Love, Bethany A. O’Hara, Gretchen V. Gee, Aisling S. Dugan, Ryan O’Rourke , et al. · 2022

JC polyomavirus (JCPyV) is a small, non‐enveloped virus that persists in the kidney in about half the adult population. In severely immune‐compromised individuals JCPyV causes the neurodegenerative disease progressive multifocal leukoencep…

Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells Open

Bethany A. O’Hara, Gretchen V. Gee, Sheila A. Haley, Jenna Morris‐Love, Charlotte Nyblade , et al. · 2021

Several classes of immunomodulators are used for treating relapsing-remitting multiple sclerosis (RRMS). Most of these disease-modifying therapies, except teriflunomide, carry the risk of progressive multifocal leukoencephalopathy (PML), a…

Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells Open

Sheila A. Haley, Bethany A. O’Hara, Walter J. Atwood · 2020

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor Open

Bethany A. O’Hara, Jenna Morris‐Love, Gretchen V. Gee, Sheila A. Haley, Walter J. Atwood · 2020

The human polyomavirus, JCPyV, is the causative agent of progressive multifocal leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial infection with JCPyV is common and the virus establishes a long-term persis…

Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus Open

Benedetta Assetta, Jenna Morris‐Love, Gretchen V. Gee, Abigail L. Atkinson, Bethany A. O’Hara , et al. · 2019

JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells Open

Jenna Morris‐Love, Gretchen V. Gee, Bethany A. O’Hara, Benedetta Assetta, Abigail L. Atkinson , et al. · 2019

JC polyomavirus (JCPyV) is a ubiquitous human pathogen that causes progressive multifocal leukoencephalopathy (PML), a severe and often fatal neurodegenerative disease in immunocompromised or immunomodulated patients. The mechanisms respon…

Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus Open

Bethany A. O’Hara, Gretchen V. Gee, Walter J. Atwood, Sheila A. Haley · 2018

JC polyomavirus (JCPyV) establishes a lifelong persistence in roughly half the human population worldwide. The cells and tissues that harbor persistent virus in vivo are not known, but renal tubules and other urogenital epithelial cells ar…

Human Polyomavirus Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus Open

Sheila A. Haley, Bethany A. O’Hara, Christian D. S. Nelson, Frances L.P. Brittingham, Kammi Henriksen , et al. · 2015

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