Shekhar C. Mande
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View article: Geographical access to COVID-19 testing centers in India
Geographical access to COVID-19 testing centers in India Open
Background Geographic accessibility to testing constitutes an important part of pandemic preparedness. However, there is no data on access to COVID-19 testing centers in India. Our study looks at the current geographical accessibility to t…
View article: Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant Mycobacterium tuberculosis Strains
Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant Mycobacterium tuberculosis Strains Open
The long regimen of drug therapy, the emergence of drug-resistance (DR), and infections with non-tuberculous mycobacteria (NTMs) are alarming challenges in controlling tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (M.tb…
View article: Demography, sanitation and previous disease prevalence associate with COVID-19 deaths across Indian States
Demography, sanitation and previous disease prevalence associate with COVID-19 deaths across Indian States Open
The severity of COVID-19 has varied across regions, with a disproportionately higher case-fatality ratio in developed nations. In India, states with higher income have reported more COVID-19 related deaths compared to lower-income states. …
View article: Exploring Methods for the Detection and Analysis of Antidiabetic Drugs in Pharmaceutical Formulations
Exploring Methods for the Detection and Analysis of Antidiabetic Drugs in Pharmaceutical Formulations Open
Analytical methods are employed for determining the chemical or physical properties of an analyte, chemical substance, chemical element, or mixture. Various analytical techniques are employed in the pharmaceutical industry to estimate the …
View article: Rajagopala Chidambaram (1936–2025)
Rajagopala Chidambaram (1936–2025) Open
Obituary for Rajagopala Chidambaram.
View article: A Review on Impurity Profiling In Pharmaceutical Substances
A Review on Impurity Profiling In Pharmaceutical Substances Open
The term "impurity profiling" describes a group of analytical techniques aimed at detecting, identifying, and quantifying residual solvents and organic and inorganic impurities in bulk medications and pharmaceutical formulations. This is t…
View article: Demography, sanitation and previous disease prevalence associate with Covid-19 deaths across Indian states
Demography, sanitation and previous disease prevalence associate with Covid-19 deaths across Indian states Open
Severity of Covid-19 diseases has been disproportionate with higher case-fatality ratio affecting developed nations. In India, states with higher income have reported a greater number of deaths compared to lower income states. The global b…
View article: Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria
Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria Open
Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism. The generation of free radicals in the Class Ib ribonuc…
View article: The role of thioredoxin proteins in Mycobacterium tuberculosis probed by proteome-wide target profiling
The role of thioredoxin proteins in Mycobacterium tuberculosis probed by proteome-wide target profiling Open
Mycobacterium tuberculosis encounters diverse microenvironments, including oxidative assault (ROS and RNS), when it attempts to establish itself within its human host. Therefore, redox sensory and regulation processes are assumed significa…
View article: Demography, hygiene and previous disease prevalence as plausible risk factors associated with Covid-19 deaths across Indian states
Demography, hygiene and previous disease prevalence as plausible risk factors associated with Covid-19 deaths across Indian states Open
Severity of Covid-19 diseases has been disproportionate with higher case-fatality ratio affecting developed nations. In India, states with higher income have reported more number of deaths compared to lower income states. The global burden…
View article: Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases
Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases Open
Class I ribonucleotide reductases consisting of R1 and R2 subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism. The generation of free radicals in the Class Ib ribon…
View article: The role of thioredoxin proteins in<i>Mycobacterium tuberculosis</i>probed by proteome-wide target profiling
The role of thioredoxin proteins in<i>Mycobacterium tuberculosis</i>probed by proteome-wide target profiling Open
Mycobacterium tuberculosis encounters diverse microenvironments as it attempts to establish itself within its human host. The bacterium survives oxidative assault (ROS and RNS) when it is inside the host macrophages. Redox sensory and regu…
View article: Chaperonin Abundance Enhances Bacterial Fitness
Chaperonin Abundance Enhances Bacterial Fitness Open
The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Es…
View article: Structure-sequence features based prediction of phosphosites of Serine/Threonine Protein Kinases of Mycobacterium tuberculosis
Structure-sequence features based prediction of phosphosites of Serine/Threonine Protein Kinases of Mycobacterium tuberculosis Open
Elucidation of signalling events in a pathogen is potentially important to tackle the infection caused by it. Such events mediated by protein phosphorylation play important roles in infection and therefore to predict the phosphosites and s…
View article: Mortality Due to COVID-19 in Different Countries is Associated with their Demographic Character and Prevalence of Autoimmunity
Mortality Due to COVID-19 in Different Countries is Associated with their Demographic Character and Prevalence of Autoimmunity Open
In the first few months of its deadly spread across the world, COVID-19 mortality has exhibited a wide range of variability across different nations.In order to explain this phenomenon empirically, we have taken into consideration all publ…
View article: Structural aspects of lesional and non-lesional skin microbiota reveal key community changes in leprosy patients from India
Structural aspects of lesional and non-lesional skin microbiota reveal key community changes in leprosy patients from India Open
Although skin is the primary affected organ in Leprosy, the role of the skin microbiome in its pathogenesis is not well understood. Recent reports have shown that skin of leprosy patients (LP) harbours perturbed microbiota which grants inf…
View article: Correction for Kumar et al., “Facilitated Oligomerization of Mycobacterial GroEL: Evidence for Phosphorylation-Mediated Oligomerization”
Correction for Kumar et al., “Facilitated Oligomerization of Mycobacterial GroEL: Evidence for Phosphorylation-Mediated Oligomerization” Open
Volume 191, no. 21, p. 6525–6538, 2009, https://doi.org/10.1128/JB.00652-09. Page 6528, Fig. 1C: There has been an erroneous and unintentional (potential) duplication related to the two top rows of the left and middle panels. Given the age…
View article: Paradoxical Case Fatality Rate dichotomy of Covid-19 among rich and poor nations points to the “hygiene hypothesis”
Paradoxical Case Fatality Rate dichotomy of Covid-19 among rich and poor nations points to the “hygiene hypothesis” Open
In the first six months of its deadly spread across the world, the Covid-19 incidence has exhibited interesting dichotomy between the rich and the poor countries. Surprisingly, the incidence and the Case Fatality Rate has been much higher …
View article: CoRNeA: A Pipeline to Decrypt the Inter-Protein Interfaces from Amino Acid Sequence Information
CoRNeA: A Pipeline to Decrypt the Inter-Protein Interfaces from Amino Acid Sequence Information Open
Decrypting the interface residues of the protein complexes provides insight into the functions of the proteins and, hence, the overall cellular machinery. Computational methods have been devised in the past to predict the interface residue…
View article: Chaperonin Abundance Boosts Bacterial Fitness
Chaperonin Abundance Boosts Bacterial Fitness Open
The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Es…
View article: Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers
Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers Open
Although 23% of world population is infected with Mycobacterium tuberculosis (M. tb), only 5-10% manifest the disease. Individuals surely exposed to M. tb that remain asymptomatic are considered potential latent TB (LTB) cases. Such asympt…