Shelby C. Osburn
YOU?
Author Swipe
View article: Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans
Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans Open
This study demonstrates that aging alters the transcriptional landscape of PBMCs at rest and in response to acute high-intensity exercise. Older adults exhibited greater transcriptomic responsiveness to exercise, particularly in pathways r…
View article: Novel effects of reverse transcriptase inhibitor supplementation in skeletal muscle of old mice
Novel effects of reverse transcriptase inhibitor supplementation in skeletal muscle of old mice Open
Recent studies suggest that the nucleoside reverse transcriptase inhibitor 3TC may improve brain health and cognitive function in old mice, but its effects on other aging tissues have not been comprehensively studied. This is the first stu…
View article: Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy
Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy Open
Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-asso…
View article: Peripheral quantitative computed tomography is a valid imaging technique for tracking changes in skeletal muscle cross‐sectional area
Peripheral quantitative computed tomography is a valid imaging technique for tracking changes in skeletal muscle cross‐sectional area Open
Peripheral quantitative computed tomography (pQCT) has recently expanded to quantifying skeletal muscle, however its validity to determine muscle cross‐sectional area (mCSA) compared to magnetic resonance imaging (MRI) is unknown. Eleven m…
View article: Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy
Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy Open
Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-asso…
View article: Resistance training diminishes mitochondrial adaptations to subsequent endurance training in healthy untrained men
Resistance training diminishes mitochondrial adaptations to subsequent endurance training in healthy untrained men Open
We investigated the effects of performing a period of resistance training (RT) on the performance and molecular adaptations to a subsequent period of endurance training (ET). Twenty‐five young adults were divided into an RT+ET group ( n = …
View article: Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training
Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training Open
We investigated the effects of performing a period of resistance training (RT) on the performance and molecular adaptations to a subsequent period of endurance training (ET). Twenty-five young adults were divided into RT+ET (n=13), which u…
View article: The reverse transcriptase inhibitor <scp>3TC</scp> protects against age‐related cognitive dysfunction
The reverse transcriptase inhibitor <span>3TC</span> protects against age‐related cognitive dysfunction Open
Aging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease. Major hallmarks of brain aging include neuroinflammation/immune activation and reduced neuronal health/function. These processes contribut…
View article: Molecular predictors of resistance training outcomes in young untrained female adults
Molecular predictors of resistance training outcomes in young untrained female adults Open
This study continues to delineate muscle biology differences between lower and higher responders to resistance training and is unique in that a female population was interrogated. As has been reported in prior studies, increases in satelli…
View article: Skeletal Muscle DNA Methylation and mRNA Responses to a Bout of Higher versus Lower Load Resistance Exercise in Previously Trained Men
Skeletal Muscle DNA Methylation and mRNA Responses to a Bout of Higher versus Lower Load Resistance Exercise in Previously Trained Men Open
We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA responses to one bout of lower load (LL) versus higher load (HL) resistance exercise. Trained college-aged males (n = 11, 23 ± 4 years old, 4 ± 3 years self-re…
View article: Effects of aging and long‐term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats
Effects of aging and long‐term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats Open
We investigated the effects of aging and long‐term physical activity on markers of mitochondrial function and dynamics in the cortex and cerebellum of female rats. Additionally, we interrogated markers of oxidative damage and antioxidants.…
View article: Skeletal muscle DNA methylation and mRNA responses to a bout of higher versus lower load resistance exercise in previously trained men
Skeletal muscle DNA methylation and mRNA responses to a bout of higher versus lower load resistance exercise in previously trained men Open
We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA responses to one bout of lower-load (LL) versus higher-load (HL) resistance exercise. Trained college-aged males (n=11, 23±4 years old, 4±3 years self-reported…
View article: Changes in vastus lateralis fibre cross‐sectional area, pennation angle and fascicle length do not predict changes in muscle cross‐sectional area
Changes in vastus lateralis fibre cross‐sectional area, pennation angle and fascicle length do not predict changes in muscle cross‐sectional area Open
New Findings What is the central question of this study? Do changes in myofibre cross‐sectional area, pennation angle and fascicle length predict vastus lateralis whole‐muscle cross‐sectional area changes following resistance training? Wha…
View article: Effects of end-stage osteoarthritis on markers of skeletal muscle Long INterspersed Element-1 activity
Effects of end-stage osteoarthritis on markers of skeletal muscle Long INterspersed Element-1 activity Open
Objective Long INterspersed Element-1 (L1) is an autonomous transposable element in the genome. L1 transcripts that are not reverse transcribed back into the genome can accumulate in the cytoplasm and activate an inflammatory response via …
View article: Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle
Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle Open
Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1 or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise general…
View article: Exploring the Effects of Six Weeks of Resistance Training on the Fecal Microbiome of Older Adult Males: Secondary Analysis of a Peanut Protein Supplemented Randomized Controlled Trial
Exploring the Effects of Six Weeks of Resistance Training on the Fecal Microbiome of Older Adult Males: Secondary Analysis of a Peanut Protein Supplemented Randomized Controlled Trial Open
The bacteria inhabiting the gastrointestinal tract contribute to numerous host functions and can be altered by lifestyle factors. We aimed to determine whether a 6-week training intervention altered fecal microbiome diversity and/or functi…
View article: Enhance Trial: Effects of NAD3® on Hallmarks of Aging and Clinical Endpoints of Health in Middle Aged Adults: A Subset Analysis Focused on Blood Cell NAD+ Concentrations and Lipid Metabolism
Enhance Trial: Effects of NAD3® on Hallmarks of Aging and Clinical Endpoints of Health in Middle Aged Adults: A Subset Analysis Focused on Blood Cell NAD+ Concentrations and Lipid Metabolism Open
Limited pre-clinical and clinical data suggest theacrine or theacrine-based supplements modulate biological processes associated with lipid metabolism and aging. Herein, we sought to examine if 12 weeks of daily supplementation with a thea…
View article: Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations Open
We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men ( n = 15, age: 23 ± 3 years; training exp…
View article: Effects of Peanut Protein Supplementation on Resistance Training Adaptations in Younger Adults
Effects of Peanut Protein Supplementation on Resistance Training Adaptations in Younger Adults Open
Protein supplementation is a commonly employed strategy to enhance resistance training adaptations. However, little research to date has examined if peanut protein supplementation is effective in this regard. Thus, we sought to determine i…
View article: Proteasome- and Calpain-Mediated Proteolysis, but Not Autophagy, Is Required for Leucine-Induced Protein Synthesis in C2C12 Myotubes
Proteasome- and Calpain-Mediated Proteolysis, but Not Autophagy, Is Required for Leucine-Induced Protein Synthesis in C2C12 Myotubes Open
Muscle protein synthesis and proteolysis are tightly coupled processes. Given that muscle growth is promoted by increases in net protein balance, it stands to reason that bolstering protein synthesis through amino acids while reducing or i…
View article: Myofibril and Mitochondrial Area Changes in Type I and II Fibers Following 10 Weeks of Resistance Training in Previously Untrained Men
Myofibril and Mitochondrial Area Changes in Type I and II Fibers Following 10 Weeks of Resistance Training in Previously Untrained Men Open
Resistance training increases muscle fiber hypertrophy, but the morphological adaptations that occur within muscle fibers remain largely unresolved. Fifteen males with minimal training experience (24±4years, 23.9±3.1kg/m 2 body mass index)…
View article: Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women
Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women Open
The purpose of this study was to validate the efficacy of a customized vitamin-mineral supplement on blood biomarkers in pre-menopausal females. Women (21–40 years old) who were apparently healthy were recruited from the local community (C…
View article: Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations Open
Aim We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular markers. Methods Trained men (n=15, age: 23±3 y; training expe…
View article: Myofibril and Mitochondrial Area Changes in Type I and II Fibers Following 10 Weeks of Resistance Training in Previously Untrained Men
Myofibril and Mitochondrial Area Changes in Type I and II Fibers Following 10 Weeks of Resistance Training in Previously Untrained Men Open
Resistance training increases myofiber hypertrophy, but the morphological adaptations that occur within myofibers remain largely unresolved. Fifteen males with minimal training experience (24±4 years, 17.9±1.4 kg/m2 lean body…
View article: An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training‐induced muscle fiber hypertrophy in younger men
An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training‐induced muscle fiber hypertrophy in younger men Open
We examined the association between genotype and resistance training‐induced changes (12 wk) in dual x‐ray energy absorptiometry (DXA)‐derived lean soft tissue mass (LSTM) as well as muscle fiber cross‐sectional area (fCSA; vastus laterali…
View article: Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle
Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle Open
Resistance training (RT) alters skeletal muscle nuclear DNA methylation patterns (or the methylome). However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older untrained males (65±7 years old) p…
View article: Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults
Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults Open
The aim of this study was to investigate the effects of resistance training (RT) on the redox status of skeletal muscle in older adults. Thirteen males aged 64 ± 9 years performed full-body RT 2x/week for 6 weeks. Muscle biopsies were obta…
View article: LAT1 Protein Content Increases Following 12 Weeks of Resistance Exercise Training in Human Skeletal Muscle
LAT1 Protein Content Increases Following 12 Weeks of Resistance Exercise Training in Human Skeletal Muscle Open
Introduction: Amino acid transporters are essential for cellular amino acid transport and promoting protein synthesis. While previous literature has demonstrated the association of amino acid transporters and protein synthesis following ac…
View article: The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals
The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals Open
Several studies suggest resistance training (RT) while supplementing with various protein supplements can enhance strength and muscle mass in older individuals. However, to date, no study has examined the effects of RT with a peanut protei…
View article: A Theacrine-Based Supplement Increases Cellular NAD+ Levels and Affects Biomarkers Related to Sirtuin Activity in C2C12 Muscle Cells In Vitro
A Theacrine-Based Supplement Increases Cellular NAD+ Levels and Affects Biomarkers Related to Sirtuin Activity in C2C12 Muscle Cells In Vitro Open
There is evidence in rodents to suggest that theacrine-based supplements modulate tissue sirtuin activity as well as other biological processes associated with aging. Herein, we examined if a theacrine-based supplement (termed NAD3) altere…