Sheldon Chen
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View article: Vitamin D Prevents Gestational Diabetes Mellitus via Modulating Glucose Metabolism in a Mouse Model
Vitamin D Prevents Gestational Diabetes Mellitus via Modulating Glucose Metabolism in a Mouse Model Open
Gestational diabetes mellitus (GDM) is a common disease during pregnancy that has adverse effects on both the mother and fetus. There is currently rare researches on the effect of vitamin supplementation on GDM pregnant mother and their of…
View article: Safely correct hyponatremia with continuous renal replacement therapy: A flexible, <scp>all‐purpose</scp> method based on the mixing paradigm
Safely correct hyponatremia with continuous renal replacement therapy: A flexible, <span>all‐purpose</span> method based on the mixing paradigm Open
Treating chronic hyponatremia by continuous renal replacement therapy (CRRT) is challenging because the gradient between a replacement fluid's [sodium] and a patient's serum sodium can be steep, risking too rapid of a correction rate with …
View article: Ratio Profile: Physiologic Approach to Estimating Appropriate Intravenous Fluid Rate to Manage Hyponatremia in the Syndrome of Inappropriate Antidiuresis
Ratio Profile: Physiologic Approach to Estimating Appropriate Intravenous Fluid Rate to Manage Hyponatremia in the Syndrome of Inappropriate Antidiuresis Open
A hyponatremic patient with the syndrome of inappropriate antidiuresis (SIAD) gets normal saline (NS), and the plasma sodium decreases, paradoxically. To explain, desalination is often invoked: if urine is more concentrated than NS, the fl…
View article: Hemoconcentration of Creatinine Minimally Contributes to Changes in Creatinine during the Treatment of Decompensated Heart Failure
Hemoconcentration of Creatinine Minimally Contributes to Changes in Creatinine during the Treatment of Decompensated Heart Failure Open
Key Points Hemoconcentration is a minimal contributor to changes in serum creatinine during treatment of decompensated heart failure. Changes in GFR is the primary driver of serum creatinine in treatment of decompensated heart failure. Bac…
View article: [Creatinine] can change in an unexpected direction due to the volume change rate that interacts with kinetic GFR: Potentially positive paradox
[Creatinine] can change in an unexpected direction due to the volume change rate that interacts with kinetic GFR: Potentially positive paradox Open
[Creatinine] was proved to change in the opposite direction of the kinetic GFR (GFRK ), but does the [creatinine] also change in the opposite direction of the volume rate? If volume is administered and the [creatinine] actually goes up, th…
View article: In creatinine kinetics, the glomerular filtration rate always moves the serum creatinine in the opposite direction
In creatinine kinetics, the glomerular filtration rate always moves the serum creatinine in the opposite direction Open
All else being equal, a change in the kinetic GFR obligates the [creatinine] to change in the opposite direction. This does not negate the fact that an increasing [creatinine] can be compatible with a rising kinetic GFR, due to differences…
View article: Improving on the Adrogué–Madias Formula
Improving on the Adrogué–Madias Formula Open
The Adrogué–Madias (A-M) formula is correct as written, but technically, it only works when adding 1 L of an intravenous (IV) fluid. For all other volumes, the A-M algorithm gives an approximate answer, one that diverges further from the t…
View article: Perspectives From an Onconephrology Interest Group: Conference Report
Perspectives From an Onconephrology Interest Group: Conference Report Open
Introduction and objective: Onconephrology is a new and evolving field that deals with kidney complications in patients with cancer as well as the management of cancer in patients with preexisting kidney disease. With increasing numbers of…
View article: The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury Open
In a critically ill population, use of kinetic estimates of renal function impacted medication dosing in a substantial proportion of AKI participants. Use of kinetic estimates in clinical practice should lower the incidence of medication t…
View article: Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience
Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience Open
Our data demonstrate that CPI related AKI occurs relatively late after CPI therapy. Our biopsy data demonstrate that ATIN is the most common pathological finding; however it can frequently co-occur with other glomerular pathologies, which …
View article: Kinetic glomerular filtration rate equation can accommodate a changing body volume: Derivation and usage of the formula
Kinetic glomerular filtration rate equation can accommodate a changing body volume: Derivation and usage of the formula Open
Ascertaining a patient's kidney function is more difficult to do when the serum creatinine is changing than when it is stable. To accomplish the task, various kinetic clearance equations have been developed. To date, however, none of them …
View article: Kinetic Sodium Equation with Built-In Rate of Correction: Aid to Prescribing Therapy for Hyponatremia or Hypernatremia
Kinetic Sodium Equation with Built-In Rate of Correction: Aid to Prescribing Therapy for Hyponatremia or Hypernatremia Open
Purpose Both hyponatremia and hypernatremia occur frequently in patients with cancer. To understand these disorders, investigators have mathematically modeled the serum sodium concentration in humans. Methods We expanded the model to incor…
View article: Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes
Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes Open
In the last few decades a change in lifestyle has led to an alarming increase in the prevalence of obesity and obesity-associated complications. Obese patients are at increased risk of developing hypertension, heart disease, insulin resist…
View article: Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy
Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy Open
Background/Aims: Tumor necrosis factor (TNF)-α is believed to play a role in diabetic kidney disease. This study explores the specific effects of TNF-α with regard to nephropathy-relevant parameters in the podocyte. Methods: Cultured mouse…