Explanipedia

Leveraging Change Management Principles to Implement Computer-Based Assessments in a PharmD Program Open

Curtis G. Jefferson, Shelly L. Gray, Tim Wentzel, Aaron Tu, Clayton English , et al. · 2025

Deprescribing Central Nervous System-Active Medications Among Community-Dwelling Older Adults with Dementia in Primary Care: A Feasibility Study Open

Elizabeth A. Phelan, Benjamin H. Balderson, Monica Fujii, Vina F. Graham, Mary Kay Theis , et al. · 2025

Central nervous system (CNS)-active medications pose serious health risks for older adults with dementia but are nonetheless commonly used. Few deprescribing interventions have focused on people with dementia. We conducted a one-arm pilot …

Cumulative Anticholinergic Exposure and Change in Gait Speed and Grip Strength in Older Adults Open

Shelly L. Gray, Yu‐Ru Su, Tesfahun C. Eshetie, Andrea Z. LaCroix, Zachary A. Marcum , et al. · 2025

Importance Anticholinergics have been associated with functional decline in older adults. Past studies have assumed constant effects over time and have not considered the etiologically relevant exposure window. Objective To examine the ass…

Proton Pump Inhibitor Use and Incident Hypertension in Menopausal Women Open

Ahmed I. Soliman, Jean Wactawski‐Wende, Amy E. Millen, Shelly L. Gray, Charles B. Eaton , et al. · 2025

Background Proton pump inhibitors (PPIs) could affect blood pressure regulation by suppressing gastric acid required for the conversion of oral nitrite into nitric oxide. Whether PPI use is associated with incident hypertension remains unk…

Updating <span>STEADI</span> for Primary Care: Recommendations From the American Geriatrics Society Workgroup Open

Theodore M. Johnson, Jennifer L. Vincenzo, Bryanna De Lima, Colleen M. Casey, Shelly L. Gray , et al. · 2025

In 2012, the Centers for Disease Control and Prevention (CDC) released STEADI (Stopping Elderly Accidents, Deaths and Injuries) toolkit which is based on the 2011 American Geriatrics Society/British Geriatrics Society (AGS/BGS) fall preven…

Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in Parkinson Disease Open

Thanh Phuong Pham Nguyen, Dylan Thibault, Shelly L. Gray, Daniel Weintraub, Allison W. Willis · 2025

Purpose Anticholinergic medication use measured via the Anticholinergic Cognitive Burden (ACB) scale has been associated with an increased dementia incidence in older adults but has not been explored specifically for Parkinson disease deme…

Anticholinergic drugs and dementia risk: Using stem cell–based studies to complement pharmacoepidemiology Open

Tiara A. Schwarze‐Taufiq, Inez K.A. Pranoto, Kathleen K.S. Hui, C. Kinoshita, Onchee Yu , et al. · 2025

BACKGROUND Anticholinergic (AC) use remains common in older adults despite evidence of safety risks, including increased risk in dementia. Pharmacoepidemiology studies from various populations report associations between specific anticholi…

Differential Effects of Anticholinergic Medications in Patient hiPSC‐Derived Neurons Open

Tiara A. Schwarze‐Taufiq, Inez K.A. Pranoto, Kathleen K.S. Hui, Jordan Ogg, Ruowei Zhu , et al. · 2024

Background Anticholinergic (AC) use remains common in older adults despite evidence of safety risks, including dementia risk. Evidence from population studies suggests that dementia risk may vary by AC class. This variation might be explai…

DISTINCTIVE NEURONAL RESPONSES TO VARIOUS ANTICHOLINERGICS IN THE ACT COHORT HIPSC-DERIVED NEURONS Open

Inez K.A. Pranoto, Tiara Schwarze-Taufiq, Kathleen K.S. Hui, Ruowei Zhu, Jordan Ogg , et al. · 2024

Anticholinergic medications remain widely used among older adults despite evidence of safety concerns, including dementia risk. Clinical cohort studies have linked certain anticholinergic classes, such as antidepressants and bladder antimu…

Association Between Cumulative Anticholinergic Use and White Matter Hyperintensity Burden Open

Kevin H. Li, Chloe Krakauer, Jennifer Nelson, Paul K. Crane, Jalal B. Andre , et al. · 2024

Background Anticholinergic medication use has been found to be associated with higher dementia risk and cognitive decline in older adults. The presence of a biologic pathway through changes to white matter hyperintensities (WMH) remains un…

The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias Open

Nicole M. Gatto, Anne Renz, Sarah E. Tom, Mary Lyons, J Macuiba , et al. · 2024

Background: Adult Changes in Thought (ACT), a prospective cohort study, enrolls older adult members of Kaiser Permanente Washington. We describe an ambitious project to abstract medical records facilitating epidemiological investigation. M…

A Coordinated Approach to School-Wide Faculty & Staff Development Open

Curtis G. Jefferson, Lauren R. Cirrincione, Shelly L. Gray, Yvonne G. Lin, Leigh Ann Mike , et al. · 2024

Reducing Central Nervous System–Active Medications to Prevent Falls and Injuries Among Older Adults Open

Elizabeth A. Phelan, Brian D. Williamson, Benjamin H. Balderson, Andrea J. Cook, Annalisa V. Piccorelli , et al. · 2024

Importance High-risk medications that contribute to adverse health outcomes are frequently prescribed to older adults. Deprescribing interventions reduce their use, but studies are often not designed to examine effects on patient-relevant …

Deprescribing interventions in older adults: An overview of systematic reviews Open

Shiyun Chua, Adam Todd, Emily Reeve, Susan M. Smith, Julia Fox , et al. · 2024

Objective The growing deprescribing field is challenged by a lack of consensus around evidence and knowledge gaps. The objective of this overview of systematic reviews was to summarize the review evidence for deprescribing interventions in…

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Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Angeles, Alexander Smith , et al. · 2024

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Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Ángeles, Alexander Smith , et al. · 2024

American Geriatrics Society response to the World Falls Guidelines Open

Elizabeth Eckstrom, Jennifer L. Vincenzo, Colleen M. Casey, Shelly L. Gray, Kristina Cosley , et al. · 2023

Falls are a major cause of preventable death, injury, and reduced independence in adults aged 65 years and older. The American Geriatrics Society and British Geriatrics Society (AGS/BGS) published a guideline in 2001, revised in 2011, addr…

Medication use quality and safety in older adults: 2022 update Open

Shelly L. Gray, Nicole Brandt, Kenneth E. Schmader, Joseph T. Hanlon · 2023

Improving the quality of medication use and medication safety are important priorities for healthcare providers who care for older adults. The objective of this article was to identify four exemplary articles with this focus in 2022. We se…

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Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Angeles, Alexander Smith , et al. · 2023

WHO WE AREFounded in 1942, the American Geriatrics Society (AGS) is a nationwide, not-for-profit society of geriatrics healthcare professionals dedicated to improving the health, independence, and quality of life of older people.Our member…

Differential Effects of Anticholinergic Medications in a Human Neuronal Model of AD Open

Tiara A. Schwarze‐Taufiq, Eleanore Sammeth, Paul K. Crane, Shelly L. Gray, Jessica E. Young · 2023

Background Anticholinergic (ACh) use remains common in older adults despite evidence of safety risks, including dementia risk. Evidence from population studies suggests that dementia risk may vary by ACh class. This variation might be expl…

The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A resource for research on the aging brain and Alzheimer’s disease and related dementias Open

Paul K. Crane, Bonnie K. Lind, Tammy S. Dodd, Mary Lyons, J Macuiba , et al. · 2023

Background Adult Changes in Thought (ACT) is a prospective cohort study of older adults from Seattle, Washington, USA. Participants are enrolled from Kaiser Permanente Washington membership and may consent for autopsy. Many participants ha…

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Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Angeles, Alexander Smith , et al. · 2023

WHO WE AREFounded in 1942, the American Geriatrics Society (AGS) is a nationwide, not-for-profit society of geriatrics healthcare professionals dedicated to improving the health, independence, and quality of life of older people.Our member…

Systematic Review and Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults: An Update Open

Shelly L. Gray, Subashan Perera, Tim Soverns, Joseph T. Hanlon · 2023

Comparative safety of antimuscarinics versus mirabegron for overactive bladder in Parkinson disease Open

Danielle S. Abraham, Thanh Phuong Pham Nguyen, Craig Newcomb, Shelly L. Gray, Sean Hennessy , et al. · 2023

Potentially inappropriate medications in older adults with Parkinson disease before and after hospitalization for injury Open

Thanh Phuong Pham Nguyen, Shelly L. Gray, Craig Newcomb, Qing Liu, Ali G. Hamedani , et al. · 2023

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Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Angeles, Alexander Smith , et al. · 2023

WHO WE AREFounded in 1942, the American Geriatrics Society (AGS) is a nationwide, not-for-profit society of geriatrics healthcare professionals dedicated to improving the health, independence, and quality of life of older people.Our member…

Issue Information Open

Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Angeles, Alexander Smith , et al. · 2023

WHO WE AREFounded in 1942, the American Geriatrics Society (AGS) is a nationwide, not-for-profit society of geriatrics healthcare professionals dedicated to improving the health, independence, and quality of life of older people.Our member…

Issue Information Open

Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Angeles, Alexander Smith , et al. · 2023

WHO WE AREFounded in 1942, the American Geriatrics Society (AGS) is a nationwide, not-for-profit society of geriatrics healthcare professionals dedicated to improving the health, independence, and quality of life of older people.Our member…

A health-system-embedded deprescribing intervention targeting patients and providers to prevent falls in older adults (STOP-FALLS trial): study protocol for a pragmatic cluster-randomized controlled trial Open

Benjamin H. Balderson, Shelly L. Gray, Monica Fujii, Kanichi G. Nakata, Brian D. Williamson , et al. · 2023

Issue Information Open

Joseph G. Ouslander, Boca Raton, Debra Saliba, Los Angeles, Alexander Smith , et al. · 2023

WHO WE AREFounded in 1942, the American Geriatrics Society (AGS) is a nationwide, not-for-profit society of geriatrics healthcare professionals dedicated to improving the health, independence, and quality of life of older people.Our member…

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