Shelton W. Wright
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View article: An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of <i>Klebsiella pneumoniae</i> pneumonia
An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of <i>Klebsiella pneumoniae</i> pneumonia Open
Klebsiella pneumoniae is a leading cause of both hospital- and community-acquired pneumonia. Nanomaterials have the potential to deliver antibiotics directly to sites of infection with improved pharmacokinetics and to avoid development of …
View article: Pre-referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study
Pre-referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study Open
Objective: Early antibiotics are considered critical for bacterial sepsis treatment, although the benefit of this early timing may differ by the presence of shock. Little evidence exists from low- or middle-income settings. In patients ref…
View article: Derivation and external validation of community-acquired pneumonia subphenotypes in Southeast Asia: a secondary analysis of prospective cohort studies
Derivation and external validation of community-acquired pneumonia subphenotypes in Southeast Asia: a secondary analysis of prospective cohort studies Open
Supported by US NIH awards T32HL007287, F32HL168809, K08HL157562, U01AI115520, R01AI137111, R01GM114029, R21AI173435, R01HL113382, the Wellcome Trust grants 090219/Z/09/Z, 101103/Z/13/Z, 106680/B/14/Z, and 106698/B/14/Z, the US National Ca…
View article: Research Priorities for Noninvasive Sampling of the Lower Respiratory Tract during Acute Respiratory Failure: An Official American Thoracic Society Workshop Report
Research Priorities for Noninvasive Sampling of the Lower Respiratory Tract during Acute Respiratory Failure: An Official American Thoracic Society Workshop Report Open
Research using lower respiratory tract (LRT) sampling may lead to improved understanding and management of patients with acute respiratory failure (ARF). Research bronchoscopy is a valuable tool for sampling the LRT during ARF. However, br…
View article: Pneumonia-specific plasma metabolite profiles among patients hospitalised with infection in Southeast Asia
Pneumonia-specific plasma metabolite profiles among patients hospitalised with infection in Southeast Asia Open
Background Community-acquired pneumonia (CAP) is a major public health threat globally but is understudied in regions with the highest burden. The host immune response during infection may differ based on the site of infection. We hypothes…
View article: Dysfunctional host cellular immune responses are associated with mortality in melioidosis
Dysfunctional host cellular immune responses are associated with mortality in melioidosis Open
Melioidosis is a tropical infection caused by the intracellular pathogen Burkholderia pseudomallei, an underreported and emerging global threat. As melioidosis-associated mortality is frequently high despite antibiotics, novel management s…
View article: γδ T Cells Mediate Protection against Neutrophil-associated Lung Inflammation in Pulmonary Melioidosis
γδ T Cells Mediate Protection against Neutrophil-associated Lung Inflammation in Pulmonary Melioidosis Open
Pulmonary melioidosis is a severe tropical infection caused by Burkholderia pseudomallei and is associated with high mortality, despite early antibiotic treatment. γδ T cells have been increasingly implicated as drivers of the host neutrop…
View article: Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients Open
Melioidosis, infection caused by Burkholderia pseudomallei , is characterized by robust innate immune responses. We have previously reported associations of TLR1 single nucleotide missense variant rs76600635 with mortality and of TLR5 nons…
View article: Prognostic Accuracy of Screening Tools for Clinical Deterioration in Adults With Suspected Sepsis in Northeastern Thailand: A Cohort Validation Study
Prognostic Accuracy of Screening Tools for Clinical Deterioration in Adults With Suspected Sepsis in Northeastern Thailand: A Cohort Validation Study Open
Background We sought to assess the performance of commonly used clinical scoring systems to predict imminent clinical deterioration in patients hospitalized with suspected infection in rural Thailand. Methods Patients with suspected infect…
View article: Statin Use and Reduced Risk of Pneumonia in Patients with Melioidosis: A Lung-Specific Statin Association
Statin Use and Reduced Risk of Pneumonia in Patients with Melioidosis: A Lung-Specific Statin Association Open
Rationale: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) use is associated with a lower risk of incident pneumonia and, less robustly, with nonpulmonary infections. Whether statin use is associated with a lower risk of…
View article: IL-1R2-based biomarker models predict melioidosis mortality independent of clinical data
IL-1R2-based biomarker models predict melioidosis mortality independent of clinical data Open
Introduction Melioidosis is an often-fatal tropical infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei , but few studies have identified promising biomarker candidates to predict outcome. Methods In 78 prospe…
View article: Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment (qSOFA) score in patients hospitalised with suspected infection in southeast Asia: a cohort study
Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment (qSOFA) score in patients hospitalised with suspected infection in southeast Asia: a cohort study Open
National Institutes of Health, Wellcome Trust.
View article: Data set - Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment score (qSOFA) in patients hospitalized with suspected infection in southeast Asia.
Data set - Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment score (qSOFA) in patients hospitalized with suspected infection in southeast Asia. Open
This is a part of prospective observational (non-interventional) study of community-acquired sepsis and severe sepsis in Sunpasithiprasong Hospital, Ubon Ratchathani province, northeast Thailand (NCT02217592; Ubon-sepsis cohort) and a mult…
View article: Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro
Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro Open
Melioidosis is an often-severe tropical infection caused by Burkholderia pseudomallei (Bp) with high associated morbidity and mortality. Burkholderia thailandensis (Bt) is a closely related surrogate that does not require BSL-3 conditions …
A 2-Biomarker Model Augments Clinical Prediction of Mortality in Melioidosis Open
Background Melioidosis, infection caused by Burkholderia pseudomallei, is a common cause of sepsis with high associated mortality in Southeast Asia. Identification of patients at high likelihood of clinical deterioration is important for g…
View article: Exonic sequencing identifies <i>TLR1</i> genetic variation associated with mortality in Thais with melioidosis
Exonic sequencing identifies <i>TLR1</i> genetic variation associated with mortality in Thais with melioidosis Open
Melioidosis, an infectious disease caused by the bacterium Burkholderia pseudomallei, is a common cause of sepsis in Southeast Asia. We investigated whether novel TLR1 coding variants are associated with outcome in Thai patients with melio…
View article: Severe iron poisoning treated with prolonged deferoxamine infusion: a case report
Severe iron poisoning treated with prolonged deferoxamine infusion: a case report Open
The incidence of iron poisoning, once the most common cause of fatal pediatric unintentional ingestions, and the use of its antidote deferoxamine have declined. We describe a case of a 17-year-old girl who presented to a hospital following…
View article: Immunomodulatory Effects of Lactoferrin during Burkholderia thailandensis Infection
Immunomodulatory Effects of Lactoferrin during Burkholderia thailandensis Infection Open
Melioidosis is a tropical infection caused by the Gram-negative bacterium and Tier 1 select agent Burkholderia pseudomallei. Agnostic whole exome sequencing of DNA from patients with melioidosis has identified single nucleotide variants in…