Weiliang Shen
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View article: Microbial Imbalance and Stochastic Assembly Drive Gut Dysbiosis in White-Gill Diseased Larimichthys crocea (Richardson, 1846)
Microbial Imbalance and Stochastic Assembly Drive Gut Dysbiosis in White-Gill Diseased Larimichthys crocea (Richardson, 1846) Open
White-gill disease has emerged as one of the major health threats in large yellow croaker Larimichthys crocea (Richardson, 1846) aquaculture, yet its underlying microbial mechanisms remain poorly understood. In this study, we investigated …
View article: The integrin protein ITGβ1 effectively suppresses porcine epidemic diarrhea virus replication through facilitating MDA5 oligomerization and subsequent activation of the type I interferon signaling pathway
The integrin protein ITGβ1 effectively suppresses porcine epidemic diarrhea virus replication through facilitating MDA5 oligomerization and subsequent activation of the type I interferon signaling pathway Open
Integrins are cell surface adhesion molecules. They bridge the intracellular and extracellular environments, enabling bidirectional transmembrane signaling and regulating immune responses. However, it remains unclear whether integrin prote…
View article: Machine learning predicts post-transplant muscle loss in hepatocellular carcinoma patients without sarcopenia
Machine learning predicts post-transplant muscle loss in hepatocellular carcinoma patients without sarcopenia Open
View article: Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice
Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice Open
With the progression of aging, age-dependent obesity and metabolic disorders have garnered increasing attention, yet their underlying mechanisms remain poorly understood. Dysregulation of iron homeostasis is strongly linked to aging; howev…
View article: Elastin-derived extracellular matrix fragments drive aging through innate immune activation
Elastin-derived extracellular matrix fragments drive aging through innate immune activation Open
The roles of cells in systemic aging have been systematically investigated, while the roles of the extracellular matrix (ECM) and its degradation have been largely overlooked. Herein, we show that the serum contents of elastin-, hyaluronic…
View article: Multiple Injections and Injections ≤6 Month Injections Before Rotator Cuff Repair May Increase the Risk of Retear: A Propensity Score–Matched Study
Multiple Injections and Injections ≤6 Month Injections Before Rotator Cuff Repair May Increase the Risk of Retear: A Propensity Score–Matched Study Open
Background: The role of preoperative corticosteroid injections (CSIs) in rotator cuff repair (RCR) outcomes is controversial, with mixed evidence regarding their effect on tendon healing and postoperative recovery. Purpose: To control for …
View article: Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration
Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration Open
As a cell‐deficient tissue, the scarcity of endogenous stem cells significantly hampers the regeneration of tissue structure and restoration of motor function following tendon injury. To engineer large‐scale transplantable stem cell‐derive…
View article: T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker ( <i>Larimichthys crocea</i> )
T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker ( <i>Larimichthys crocea</i> ) Open
The large yellow croaker ( Larimichthys crocea ) is a key aquaculture species, yet gaps in high‐quality genomes hinder studies of centromeric and adaptive evolution. This study presents two telomere‐to‐telomere (T2T), gapless genomes from …
View article: Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4/MyD88/NF-kB pathway to improve asthma
Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4/MyD88/NF-kB pathway to improve asthma Open
Exosomes derived from baicalin-pretreated BMSCs ameliorated airway inflammation, airway hyperresponsiveness and airway remodeling after asthma by inactivating the TLR4/MyD88/nuclear factor kappa B pathway, providing a therapeutic strategy …
View article: Flavor profiling and optimization of large yellow croaker (Larimichthys crocea) in recirculating aquaculture systems: Effects of exercise intensity assessed by advanced analytical techniques
Flavor profiling and optimization of large yellow croaker (Larimichthys crocea) in recirculating aquaculture systems: Effects of exercise intensity assessed by advanced analytical techniques Open
View article: Comparative Efficacy of Different Intracanal Medications in Multiple-Visit Root Canal Treatment: A Systematic Review and Meta-Analysis
Comparative Efficacy of Different Intracanal Medications in Multiple-Visit Root Canal Treatment: A Systematic Review and Meta-Analysis Open
View article: Scientific analysis of the lacquer lian of the Western Han Dynasty from Fengpengling site, Hunan
Scientific analysis of the lacquer lian of the Western Han Dynasty from Fengpengling site, Hunan Open
The round lacquer lian of fabric core excavated from the Fengpengling site (Hunan, China) as one of the typical lacquerwares with gold and silver decoration was analyzed by digital microscopy, Raman spectroscopy, SEM-EDS, and Py-GC/MS to o…
View article: Engineering a stem cell-embedded bilayer hydrogel with biomimetic collagen mineralization for tendon-bone interface healing
Engineering a stem cell-embedded bilayer hydrogel with biomimetic collagen mineralization for tendon-bone interface healing Open
View article: Dynamic changes of molecular pattern and cellular subpopulation in puncture-induced tendon injury model
Dynamic changes of molecular pattern and cellular subpopulation in puncture-induced tendon injury model Open
View article: Advances in clinical neurorestorative treatments in brain trauma
Advances in clinical neurorestorative treatments in brain trauma Open
View article: The effects of table tennis on the eyesight of primary and middle school students: A meta-analysis
The effects of table tennis on the eyesight of primary and middle school students: A meta-analysis Open
Objective: To systematically evaluate the influence of table tennis on the eyesight of primary and secondary school students. Methods: Literature research was conducted by computerized search of CNKI, Wanfang, and VIP databases, Web of Sci…
View article: Author Correction: Classification of distinct tendinopathy subtypes for precision therapeutics
Author Correction: Classification of distinct tendinopathy subtypes for precision therapeutics Open
View article: Optimizing drug sensitivity assays in patient-derived tumor organoids: a comparison of IC50 estimation methods and experimental parameters
Optimizing drug sensitivity assays in patient-derived tumor organoids: a comparison of IC50 estimation methods and experimental parameters Open
Patient-derived tumor organoids (PDOs) hold immense potential for personalized drug sensitivity testing, but accurate efficacy determination is crucial for clinical translation. This study investigated factors influencing the accuracy and …
View article: The Interaction between Gut Microbial Communities of All-Male Large Yellow Croakers of Different Sizes and Microbial Communities in the Aquatic Environment
The Interaction between Gut Microbial Communities of All-Male Large Yellow Croakers of Different Sizes and Microbial Communities in the Aquatic Environment Open
View article: Key Regulatory Genens Controlling Photosynthesis in Soybean
Key Regulatory Genens Controlling Photosynthesis in Soybean Open
View article: The Favorable Impact of HBcAb-Positive Grafts on Liver Transplantation for HBV-Related Hepatocellular Carcinoma
The Favorable Impact of HBcAb-Positive Grafts on Liver Transplantation for HBV-Related Hepatocellular Carcinoma Open
View article: Optimization of Neofemales Induction by 17β-Estradiol Oral Administration And Subsequent Generation Of Yy Supermales In Large Yellow Croaker (Larimichthys Crocea)
Optimization of Neofemales Induction by 17β-Estradiol Oral Administration And Subsequent Generation Of Yy Supermales In Large Yellow Croaker (Larimichthys Crocea) Open
View article: Enhancing Visual Representation for Text-based Person Searching
Enhancing Visual Representation for Text-based Person Searching Open
Text-based person search aims to retrieve the matched pedestrians from a large-scale image database according to the text description. The core difficulty of this task is how to extract effective details from pedestrian images and texts, a…
View article: Effects of induced electric field and high-pressure microjet sterilization on the physicochemical properties of milk
Effects of induced electric field and high-pressure microjet sterilization on the physicochemical properties of milk Open
This study aimed to investigate the difference between low-temperature sterilization methods including induced electric field (IEF) technology and the high-pressure microjet (HPM) and traditional thermal treatment including pasteurization …
View article: Chen’s peiyuan tang and premature ovarian failure: unveiling the mechanisms through network pharmacology
Chen’s peiyuan tang and premature ovarian failure: unveiling the mechanisms through network pharmacology Open
Background Chen’s Peiyuan Tang (CSPYT) is a compound herbal formula that has shown the potential to enhance ovarian function and reduce autophagy in ovarian granulosa cells, which plays a crucial role in follicular development and maturati…
View article: Classification of distinct tendinopathy subtypes for precision therapeutics
Classification of distinct tendinopathy subtypes for precision therapeutics Open
View article: Insight into the nitrogen-vacancy center formation in type-Ib diamond by irradiation and annealing approach
Insight into the nitrogen-vacancy center formation in type-Ib diamond by irradiation and annealing approach Open
Comprehending the microscopic formation of nitrogen vacancy (NV) centers in nitrogen-doped diamonds is crucial for enhancing the controllable preparation of NV centers and quantum applications. Irradiation followed by annealing simulations…
View article: Hypoxia-inducible factor-1α promotes macrophage functional activities in protecting hypoxia-tolerant large yellow croaker (Larimichthys crocea) against Aeromonas hydrophila infection
Hypoxia-inducible factor-1α promotes macrophage functional activities in protecting hypoxia-tolerant large yellow croaker (Larimichthys crocea) against Aeromonas hydrophila infection Open
The immune system requires a high energy expenditure to resist pathogen invasion. Macrophages undergo metabolic reprogramming to meet these energy requirements and immunologic activity and polarize to M1-type macrophages. Understanding the…
View article: Exploring the “gene–metabolite” network of ischemic stroke with blood stasis and toxin syndrome by integrated transcriptomics and metabolomics strategy
Exploring the “gene–metabolite” network of ischemic stroke with blood stasis and toxin syndrome by integrated transcriptomics and metabolomics strategy Open
A research model combining a disease and syndrome can provide new ideas for the treatment of ischemic stroke. In the field of traditional Chinese medicine, blood stasis and toxin (BST) syndrome is considered an important syndrome seen in p…
View article: A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells Open
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint damage, combined with joint bleedi…