Wei Shen Tan
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View article: Partial Cystectomy for Muscle-Invasive Bladder Cancer
Partial Cystectomy for Muscle-Invasive Bladder Cancer Open
Partial cystectomy is a surgical bladder-sparing option for selected patients with muscle-invasive bladder cancer (MIBC), urachal adenocarcinoma and diverticular bladder tumors. Partial cystectomy hold several advantages. It allows for def…
View article: Evaluating the Therapeutic Role of Lymph Node Dissection in Variant Subtype Bladder Cancer
Evaluating the Therapeutic Role of Lymph Node Dissection in Variant Subtype Bladder Cancer Open
Background: The importance of lymph node dissection (LND) at the time of radical cystectomy for urothelial carcinoma (UC) is widely accepted despite known risks. The therapeutic benefits of LND for variant subtype bladder cancer (VBC), a h…
View article: Evaluating diagnostic performance of urinary biomarkers in the surveillance of non-muscle invasive bladder carcinoma: A systematic review
Evaluating diagnostic performance of urinary biomarkers in the surveillance of non-muscle invasive bladder carcinoma: A systematic review Open
Urinary biomarkers could complement, rather than replace cystoscopy, in the surveillance of NMIBC, potentially reducing the frequency of invasive procedures. In cases of discordance, an algorithm focusing on shared decision-making and tail…
View article: Correlation between the type of esophagogastric junction and refractory reflux esophagitis
Correlation between the type of esophagogastric junction and refractory reflux esophagitis Open
EGJ type significantly influences the development of RRE, with Type III EGJ exhibiting the strongest association. An abnormal EGJ structure reduces LES pressure and increases acid exposure, thereby diminishing the efficacy of acid suppress…
View article: Long‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer
Long‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer Open
Objective To quantify the oncological risks of bladder‐sparing therapy (BST) in patients with Bacillus Calmette–Guérin (BCG)‐unresponsive non‐muscle‐invasive bladder cancer (NMIBC) compared to upfront radical cystectomy (RC). Patients and …
View article: Use of minimally invasive ultrasound transducer during tubular microdiscectomy
Use of minimally invasive ultrasound transducer during tubular microdiscectomy Open
Minimally invasive ultrasound during tubular microdiscectomy is novel. The authors report the technique during surgery for L5–S1 herniated disc. Ultrasound provided real-time visualization of the pathology and neural elements. After discec…
View article: Clinical efficacy of different surgical approaches in the treatment of thoracolumbar tuberculosis: a multicenter retrospective case–control study with a minimum 10-year follow-up
Clinical efficacy of different surgical approaches in the treatment of thoracolumbar tuberculosis: a multicenter retrospective case–control study with a minimum 10-year follow-up Open
Objective: To evaluate the long-term clinical efficacy of three different surgical approaches in treating thoracolumbar tuberculosis. Methods: A total of 176 patients with thoracolumbar tuberculosis, treated with open surgery at two hospit…
View article: Influence of lamina propria invasion extension on T1 high‐grade non‐muscle‐invasive bladder cancer in patients undergoing BCG or radical cystectomy
Influence of lamina propria invasion extension on T1 high‐grade non‐muscle‐invasive bladder cancer in patients undergoing BCG or radical cystectomy Open
Objective To evaluate the prognostic value of T1 substaging in patients treated with bacillus Calmette‐Guérin (BCG) or immediate radical cystectomy (iRC). Materials and Methods We performed an institutional review board‐approved retrospect…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Comparative Analysis of Very Reduced vs Full Dose BCG Treatment for High-Risk Non-Muscle Invasive Bladder Cancer: A Contemporary Experience from Chile
Comparative Analysis of Very Reduced vs Full Dose BCG Treatment for High-Risk Non-Muscle Invasive Bladder Cancer: A Contemporary Experience from Chile Open
BACKGROUND: Adjuvant bacillus Calmette-Guérin (BCG) is recommended for high-risk (HR) non-muscle invasive bladder cancer (NMIBC), but BCG shortages have led to exploration of reduced-dose regimens and shortened maintenance durations out of…
View article: Impact of age >70 years on oncological outcomes in patients with non‐muscle‐invasive bladder cancer treated with Bacillus Calmette–Guérin
Impact of age >70 years on oncological outcomes in patients with non‐muscle‐invasive bladder cancer treated with Bacillus Calmette–Guérin Open
Objective To evaluate the impact of age on oncological outcomes in a large contemporary cohort of patients with non‐muscle‐invasive bladder cancer (NMIBC) treated with adequate Bacillus Calmette–Guérin (BCG). Patients and Methods We perfor…
View article: Bacillus Calmette–Guérin (BCG) unresponsive non‐muscle‐invasive bladder cancer: are the subgroups equal?
Bacillus Calmette–Guérin (BCG) unresponsive non‐muscle‐invasive bladder cancer: are the subgroups equal? Open
Figure S1. Kaplan–Meier curves for the high-grade recurrence rate (A) and progression to MIBC/metastasis rate (B) of patients with BCG-unresponsive NMIBC stratified by BCG-relapsing and -refractory status. Figure S2. Kaplan–Meier curves fo…
View article: Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials
Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials Open
This study compares robot-assisted keyhole surgery with open surgery for bladder cancer. The robot-assisted approach offered less blood loss, shorter hospital stays, and fewer blood clots. No other differences were seen.
View article: Supplementary Figure 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 1. Proportion of MVPs in penile cancers.
View article: Supplementary Figure 6 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 6 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 6. Heatmap of 6 HNSCC cell lines (in duplicate) showing the methylation of the 30 probe set HPV classifier
View article: Supplementary Table 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Table 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Table 2. Primers sequences for A) HPV primers, B)analysis of CDO1 and AR gene expression and C) MSP analysis of HMX3, PPP2R5C, IRF4, FLI1.
View article: Supplementary Figure 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 2. Comparison of gene expression between PeCa and matched normal tissue for PRC2 complex members
View article: Supplementary Table 1 and Supplementary Figures 1 through 6 from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Supplementary Table 1 and Supplementary Figures 1 through 6 from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Supplementary Table 1. A)Patient details for Fresh Frozen test cohort, B) Patient details for validation cohort. Supplementary Figure 1. APOBEC mutation fraction of across multiple cancer types. Supplementary Figure 2. DNA methylation. Sup…
View article: Supplementary Figure 4 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 4 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 4. Comparison of DMR profiles across canonical features for PeCa (green) and normal squamous epithelium (red), for three candidate epigenetically regulated genes involved in the development of penile cancer (AR &CDO1).
View article: Data from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Data from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Purpose: Penile cancer is a rare malignancy in the developed world with just more than 1,600 new cases diagnosed in the United States per year; however, the incidence is much higher in developing countries. Although HPV is known to contrib…
View article: Supplementary Table 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Table 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Table 1. Patient details for A) Fresh Frozen test cohort and B) archival validation cohort
View article: Supplementary Methods from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Supplementary Methods from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Supplementary methods