Explanipedia

Healthcare Utilization and Complications Associated With Single-Use Versus Reusable Flexible Cystoscopy in Hospital Outpatient Settings Open

Ben H. Chew, Larry E. Miller, K. Morris, Yongtae Shin, Theodore Tsacogianis , et al. · 2025

Wheat crop models underestimate drought stress in semi-arid and Mediterranean environments Open

Heidi Webber, David Cooke, Chao Wang, Senthold Asseng, Pierre Martre , et al. · 2025

Association of a bacterial collagen after hydroxyproline incorporation Open

John White, Yong Y. Peng, Xuen Jen Ng, Denis Bartoschek, Veronica Glattauer , et al. · 2025

Various bacterial collagen-like proteins have been previously described and shown to have a triple helical, (Gly-Xaa Yaa)_n repeating structure. They are stable without needing any secondary modification of proline residues in th…

Risk Factors for Adverse Outcomes Following Ureteroscopy for Stone Management in US Medicare Patients Open

Manoj Monga, Ryoko Sato, John White, S Mehendale, M. Boulmani , et al. · 2025

Most URS Medicare patients had risk factors. Those with risk factors were more likely to experience sepsis, ICU admission, prolonged hospital LOS, and death. These findings underscore the need for targeted prevention and careful management…

Zeolitic imidazolate frameworks enhanced transfection efficiency of mRNA loaded lipid nanoparticles Open

Ruhani Singh, K. Bruce, Shen Y. Heazlewood, Shen Y. Heazlewood, Malisja de Vries , et al. · 2025

Zeolitic imidazolate framework encapsulation of mRNA-loaded lipid nanoparticles significantly enhance transfection efficiency, offering a promising strategy for next-generation mRNA therapeutics.

Fluorinated Peptide Hydrogels Result in Longer <i>In Vivo</i> Residence Time after Subcutaneous Administration Open

Aurélie Honfroy, Jolien Bertouille, Ana-Maria Turea, Thibault Cauwenbergh, Jessica Bridoux , et al. · 2024

Peptide-based hydrogels are of interest to biomedical applications. Herein, we have explored the introduction of fluorinated amino acids in hydrogelator H-FQFQFK-NH₂ (P1) to design a series of fluorinated peptide hydrogel…

Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages Open

Joshua Iscaro, Haitao Yu, Natalia P. Martínez, Santhni Subramaniam, Paul Joyce , et al. · 2024

Macrophages are unique immune cells attracting growing attention as a potential candidate for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme or gene‐edit macrophages hold potential across a spectrum …

Peptide Sequence Variations Govern Hydrogel Stiffness: Insights from a Multi‐Scale Structural Analysis of H‐FQFQFK‐NH<sub>2</sub>Peptide Derivatives Open

Tess De Maeseneer, Thibault Cauwenbergh, James Gardiner, John White, Wim Thielemans , et al. · 2024

Throughout the past decades, amphipathic peptide‐based hydrogels have proven to be promising materials for biomedical applications. Amphipathic peptides are known to adopt β‐sheet configurations that self‐assemble into fibers that then int…

A systematic study of the effect of lipid architecture on cytotoxicity and cellular uptake of cationic cubosomes Open

S. Pushpa Ragini, Brendan Dyett, Sampa Sarkar, Jiali Zhai, John White , et al. · 2024

The molecular architecture of the cationic lipid was linked to the internal nanostructure of the resulting cationic cubosomes with a transition to more curved cubic and hexagonal phases generally observed. Cubosomes formed from the cationi…

(105) What About the Pillow Talk? Exploring Gender Differences Between Quality of Sex and Time to Sleep Open

James Dornbush, John Codrington, Charles M. Yarborough, John White, Akhil Muthigi , et al. · 2024

Introduction The notion of a potential difference between men and women in post-coital time-to-sleep has received attention in mainstream media, perpetuating the stereotype that men fall asleep first (1-7). However, scientific literature o…

Data Testing of the 126/36 Neutron-Gamma ENDF/B-IV Coupled Library for LMFBR Core and Shield Analysis Open

John White, R.Q. Wright, Larry R. Williams, C.R. Weisbin · 2024

A description is given of the library testing program and results obtained to date in efforts to establish the library performance for a variety of important LMFBR core and shield applications. Calculational experience to date is summarize…

Preparation, physicochemical characterisation and assessment of liquid and vapour phase antimicrobial activity of essential oil loaded lipid nanoparticles Open

A.R. Mukurumbira, Robert A. Shellie, Russell Keast, Enzo A. Palombo, Rohan Shah , et al. · 2023

Many essential oils have garnered attention as promising antimicrobials; however, their inherent volatility and susceptibility to degradation limit their effective utilisation. Encapsulation can address these limitations by entrapping the …

Polysaccharide‐Targeting Lipid Nanoparticles to Kill Gram‐Negative Bacteria Open

Xiangfeng Lai, Seong Hoong Chow, Anton P. Le Brun, Benjamin W. Muir, Phillip J. Bergen , et al. · 2023

The rapid increase and spread of Gram‐negative bacteria resistant to many or all existing treatments threaten a return to the preantibiotic era. The presence of bacterial polysaccharides that impede the penetration of many antimicrobials a…

Production and Testing of the VITAMIN-B6 Fine-Group and the BUGLE-93 Broad-Group Neutron/Photon Cross-Section Libraries Derived from ENDF/B-VI Nuclear Data Open

D.T. Ingersoll, John White, R.Q. Wright, H.T. Hunter, C.O. Slater , et al. · 2023

A new multigroup cross-section library based on ENDF/B-VI data has been produced and tested for light water reactor shielding and reactor pressure vessel dosimetry applications. The broad-group library is designated BUGLE-93. The processin…

High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production Open

Shen Y. Heazlewood, Tanvir Ahmad, Benjamin Cao, Huimin Cao, Mélanie J. Domingues , et al. · 2023

Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators of HSC and cri…

Rational design of potent ultrashort antimicrobial peptides with programmable assembly into nanostructured hydrogels Open

Priscila Cardoso, Samuel Appiah Danso, Andrew Hung, Chaitali Dekiwadia, Nimish Pradhan , et al. · 2023

Microbial resistance to common antibiotics is threatening to cause the next pandemic crisis. In this context, antimicrobial peptides (AMPs) are receiving increased attention as an alternative approach to the traditional small molecule anti…

The role of glycosylation in amyloid fibril formation of bovine κ-casein Open

Barana Hewa Nadugala, Rick Hantink, Thomas Nebl, John White, Charles N. Pagel , et al. · 2023

SARS‐CoV‐2 Virus Detection Via a Polymeric Nanochannel‐Based Electrochemical Biosensor Open

Amane Shiohara, Marcin Wojnilowicz, Quanxia Lyu, Yi Pei, Christopher D. Easton , et al. · 2022

The development of simple, cost‐effective, rapid, and quantitative diagnostic tools remains critical to monitor infectious COVID‐19 disease. Although numerous diagnostic platforms, including rapid antigen tests, are developed and used, the…

Design and function of targeted endocannabinoid nanoparticles Open

Nicola Barrie, Nicholas Manolios, Jordyn Stuart, Tracy Chew, Jonathon C. Arnold , et al. · 2022

Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release Open

Julie Heremans, L Chevillard, Morgane Mannes, Jessica Mangialetto, Kaat Leroy , et al. · 2022

Variation in Hydrogel Formation and Network Structure for Telo-, Atelo- and Methacrylated Collagens Open

Malachy Maher, John White, Veronica Glattauer, Zhilian Yue, Timothy C. Hughes , et al. · 2022

As the most abundant protein in the extracellular matrix, collagen has become widely studied in the fields of tissue engineering and regenerative medicine. Of the various collagen types, collagen type I is the most commonly utilised in lab…

Biomimetic metal-organic frameworks as protective scaffolds for live-virus encapsulation and vaccine stabilization Open

Ruhani Singh, John White, Malisja de Vries, Gary Beddome, Meiling Dai , et al. · 2022

The invaluable health, economic and social impacts of vaccination are hard to exaggerate. The ability to stabilize vaccines is urgently required for their equitable distribution without the dependence on the 'cold-chain' logistics. Herein,…

A polytherapy based approach to combat antimicrobial resistance using cubosomes Open

Xiangfeng Lai, Mei‐Ling Han, Yue Ding, Seong Hoong Chow, Anton P. Le Brun , et al. · 2022

A depleted antimicrobial drug pipeline combined with an increasing prevalence of Gram-negative ‘superbugs’ has increased interest in nano therapies to treat antibiotic resistance. As cubosomes and polymyxins disrupt the outer membrane of G…

Effect of Doubling Peptide Length on the Microscopic, Macroscopic and Biological Properties of Hydrogels Open

Julie Heremans, L Chevillard, Morgane Mannes, Jessica Mangialetto, John White , et al. · 2022

Effect of Doubling Peptide Length on the Microscopic, Macroscopic and Biological Properties of Hydrogels Open

Julie Heremans, L Chevillard, Morgane Mannes, Jessica Mangialetto, John White , et al. · 2022

The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production Open

Shen Y. Heazlewood, Tanvir Ahmad, Monika Mohenska, Belinda B. Guo, Pradnya Gangatirkar , et al. · 2021

RNA processing is increasingly recognized as a critical control point in the regulation of different hematopoietic lineages including megakaryocytes responsible for the production of platelets. Platelets are anucleate cytoplasts that conta…

Investigating casein gel structure during gastric digestion using ultra-small and small-angle neutron scattering Open

Meltem Bayrak, Jitendra Mata, Jared K. Raynes, Mark Greaves, John White , et al. · 2021

Early-Stage Non-Small Cell Lung Cancer Stereotactic Body Radiation Therapy (SBRT) Outcomes in an Equal Access Military Setting Open

Avinash Chaurasia, John White, R Beckmann, Michael M. Chamberlin, Adam Horn , et al. · 2021

Introduction Lung stereotactic body radiation therapy (SBRT) is a first-line treatment for early-stage lung cancer in non-surgical candidates or those who refuse surgery. We compared our institutional outcomes from a unique patient populat…

Variation in Hydrogel Formation and Network Structure For Telo-, Atelo- and Methacrylated Collagens Open

Malachy Maher, John White, Veronica Glattauer, Zhilian Yue, Timothy C. Hughes , et al. · 2021

Resonant Acoustic Mixing Method to Produce Lipid-Based Liquid-Crystal Nanoparticles Open

Dilek Yalçın, Sarigama Rajesh, John White, Shaun C. Howard, Paul J. Pigram , et al. · 2021

Production of large-scale batches is one of the bottlenecks in nanoscience translation, and there is a significant gap between academic and industrial production settings. There is a great need and urgency to develop methods that can easil…

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