Chunsheng Jin
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View article: Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation
Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation Open
Milk oligosaccharides are crucial for neonatal development and health in mammals. Yet most milk research focuses on humans, or on domesticated mammals that are poor in milk oligosaccharide complexity. Here, we perform an exhaustive mass sp…
View article: The role of <i>Akkermansia muciniphila</i> sulfatases in colonic mucin utilisation
The role of <i>Akkermansia muciniphila</i> sulfatases in colonic mucin utilisation Open
Akkermansia muciniphila , an obligate mucin degrader, is a major member of the human colonic microbiota and has been associated positive health outcomes. Mucins are complex glycoproteins that contain heavily sulfated O -glycans and form th…
View article: Dual human milk oligosaccharide-fibre utilisation drives gut microbiome selection during weaning
Dual human milk oligosaccharide-fibre utilisation drives gut microbiome selection during weaning Open
Gut microbiome (GM) maturation in early life follows organised taxonomic successions. How weaning impacts these trajectories remains underexplored. Here, we sampled faeces from seven mother-infant dyads at pre-, early and late weaning. Enr…
View article: Endoscopic versus percutaneous drainage placement after left-sided pancreatectomy: multi-state model for defining objectifiable variables on interventional treatment for pancreatic fistula
Endoscopic versus percutaneous drainage placement after left-sided pancreatectomy: multi-state model for defining objectifiable variables on interventional treatment for pancreatic fistula Open
The present study highlights the importance of endoscopy-guided drainage placement after left-sided pancreatic resection. CRP value appeared to be a single objectifiable parameter for optimized treatment allocation.
View article: Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation
Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation Open
Breast milk oligosaccharides are crucial for neonatal development and health. Yet most milk research focuses on humans, or domesticated mammals that are historically poor in milk oligosaccharide complexity. Here, we perform an exhaustive m…
View article: Cytokine‐armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary <scp>CD56<sup>dim</sup>CD16<sup>dim</sup></scp> natural killer cells
Cytokine‐armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary <span>CD56<sup>dim</sup>CD16<sup>dim</sup></span> natural killer cells Open
Pancreatic ductal adenocarcinoma (PDAC) remains a particularly aggressive disease with few effective treatments. The PDAC tumor immune microenvironment (TIME) is known to be immune suppressive. Oncolytic viruses can increase tumor immunoge…
View article: <i>Ruminococcus torques</i> is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by <i>Bacteroides thetaiotaomicron</i>
<i>Ruminococcus torques</i> is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by <i>Bacteroides thetaiotaomicron</i> Open
Symbiotic interactions between humans and our communities of resident gut microbes (microbiota) play many roles in health and disease. Some gut bacteria utilize mucus as a nutrient source and can under certain conditions damage the protect…
View article: A monoallelic <scp><i>UXS1</i></scp> variant associated with short‐limbed short stature
A monoallelic <span><i>UXS1</i></span> variant associated with short‐limbed short stature Open
Background Serine residues in the protein backbone of heavily glycosylated proteoglycans are bound to glycosaminoglycans through a tetrasaccharide linker. UXS1 encodes UDP‐glucuronate decarboxylase 1, which catalyzes synthesis of UDP‐xylos…
View article: <i>Ruminococcus torques</i>is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by<i>Bacteroides thetaiotaomicron</i>
<i>Ruminococcus torques</i>is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by<i>Bacteroides thetaiotaomicron</i> Open
Symbiotic interactions between humans and our communities of resident gut microbes (microbiota) play many roles in health and disease. Some gut bacteria utilize mucus as a nutrient source and can under certain conditions damage the protect…
View article: Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica
Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica Open
Fasciola hepatica is a global helminth parasite of humans and their livestock. The invasive stage of the parasite, the newly excysted juvenile (NEJs), relies on glycosylated excreted-secreted (ES) products and surface/somatic molecules to …
View article: Ion Mobility-Tandem Mass Spectrometry of Mucin-type O-Glycans
Ion Mobility-Tandem Mass Spectrometry of Mucin-type O-Glycans Open
The dense O-glycosylation of mucins plays an important role in the defensive properties of the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and pathology such as COPD, cancer, and Crohn’s disease. The inhere…
View article: Organised sessions
Organised sessions Open
peer reviewed
View article: Predicting glycan structure from tandem mass spectrometry via deep learning
Predicting glycan structure from tandem mass spectrometry via deep learning Open
Curated set of LC-MS/MS data from glycomics studies. Used for training and applying CandyCrunch, a deep learning model to predict glycan structure from LC-MS/MS data, described in Urban et al., Nat Methods, 2024 and https://github.com/Boja…
View article: Predicting glycan structure from tandem mass spectrometry via deep learning
Predicting glycan structure from tandem mass spectrometry via deep learning Open
Curated set of LC-MS/MS data from glycomics studies. Used for training and applying CandyCrunch, a deep learning model to predict glycan structure from LC-MS/MS data, described in Urban et al., bioRxiv, 2023 and https://github.com/BojarLab…
View article: Predicting glycan structure from tandem mass spectrometry via deep learning
Predicting glycan structure from tandem mass spectrometry via deep learning Open
Glycans constitute the most complicated post-translational modification, modulating protein activity in health and disease. However, structural annotation from tandem mass spectrometry data is a bottleneck in glycomics, preventing high-thr…
View article: Quantification of chondroitin sulfate, hyaluronic acid and N-glycans in synovial fluid – A technical performance study
Quantification of chondroitin sulfate, hyaluronic acid and N-glycans in synovial fluid – A technical performance study Open
The HPLC-assay is suitable for analyzing CS variants and HA in synovial fluid samples, and the GAG-pattern differs between OA and recently knee injured subjects.
View article: Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria
Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria Open
The mucolytic human gut microbiota specialist Akkermansia muciniphila is proposed to boost mucin-secretion by the host, thereby being a key player in mucus turnover. Mucin glycan utilization requires the removal of protective caps, notably…
View article: Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc
Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc Open
Breast milk is abundant with functionalized milk oligosaccharides (MOs), to nourish and protect the neonate. Yet we lack a comprehensive understanding of the repertoire and evolution of MOs across Mammalia. We report ∼400 MO-species associ…
View article: Predicting glycan structure from tandem mass spectrometry via deep learning
Predicting glycan structure from tandem mass spectrometry via deep learning Open
Curated set of LC-MS/MS data from glycomics studies. Used for training and applying CandyCrunch, a deep learning model to predict glycan structure from LC-MS/MS data, described in Urban et al., bioRxiv, 2023 and https://github.com/BojarLab…