Sheng‐Hsiang Lin
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View article: A novel, non-spirometric “BMP index” for predicting severe adverse outcomes in fibrosing interstitial lung diseases
A novel, non-spirometric “BMP index” for predicting severe adverse outcomes in fibrosing interstitial lung diseases Open
Fibrosing interstitial lung diseases (fILDs) exhibit diverse clinical courses and prognoses, with no established biomarkers for predicting acute exacerbation (AE) and early death. This study introduces a novel composite “BMP index”, integr…
View article: Increased Cardiovascular Risk With Lorlatinib in Patients With ALK‐Mutated Lung Cancer: A Real‐World Comparative Study
Increased Cardiovascular Risk With Lorlatinib in Patients With ALK‐Mutated Lung Cancer: A Real‐World Comparative Study Open
Background The discovery of driver mutations has transformed advanced non–small cell lung cancer treatment, with ALK (anaplastic lymphoma kinase)–rearranged patients achieving longest overall survival. However, the risk of cancer therapy–r…
View article: Functional transition rate of the default mode network is associated with self-reported resilience
Functional transition rate of the default mode network is associated with self-reported resilience Open
Dynamic variations of information in our environment constantly influence our thoughts, requiring the brain to regulate its internal state transitions to maintain stable psychological functioning. Presumably, effective regulation of brain …
View article: Integrated drip-and-ship improves stroke transfer efficiency and outcomes: a comparison with traditional drip-and-ship and mothership models
Integrated drip-and-ship improves stroke transfer efficiency and outcomes: a comparison with traditional drip-and-ship and mothership models Open
Background While endovascular thrombectomy (EVT) has revolutionized the treatment of acute large vessel occlusions, the appropriate patient transfer paradigm remains controversial. This study compares outcomes of three transfer models in a…
View article: Improvement of Oral Anticoagulant Prescription and Long‐Term Clinical Outcomes of Patients With Atrial Fibrillation After Implementation of a Clinical Decision Support System in Outpatient Practice
Improvement of Oral Anticoagulant Prescription and Long‐Term Clinical Outcomes of Patients With Atrial Fibrillation After Implementation of a Clinical Decision Support System in Outpatient Practice Open
Background Improving adherence to oral anticoagulants (OACs) is vital for patients with atrial fibrillation. While clinical decision support systems (CDSSs) have shown benefits among hospitalized patients with atrial fibrillation, their re…
View article: Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke
Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke Open
Patients with stroke or epilepsy face an elevated risk of subsequent strokes. This nationwide retrospective cohort study analyzed data from Taiwan's National Health Insurance Research Database (2012-2020) to compare the risk of future isch…
View article: Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus Open
Background: Recent evidence supports the protective role of metformin on kidney function in patients with type 2 diabetes mellitus. However, its potential to prevent new-onset chronic kidney disease (CKD) in patients with type 2 diabetes m…
View article: Comparing immunotherapy effectiveness for unresectable hepatocellular carcinoma: infiltrative versus non-infiltrative types in real-world settings
Comparing immunotherapy effectiveness for unresectable hepatocellular carcinoma: infiltrative versus non-infiltrative types in real-world settings Open
Background: Infiltrative hepatocellular carcinoma (HCC) is often associated with an unfavorable prognosis, posing a challenge in determining the optimal therapeutic approach. Immunotherapy, employing immune checkpoint inhibitors (ICIs), ha…
View article: Long‐Term Statin Use Is Associated With Reduced Rates of Adverse Events in Patients With Newly Diagnosed Atrial Fibrillation
Long‐Term Statin Use Is Associated With Reduced Rates of Adverse Events in Patients With Newly Diagnosed Atrial Fibrillation Open
Background The effectiveness of statin use in preventing adverse cardiovascular events in individuals with atrial fibrillation (AF) has remained uncertain. This study aimed to assess whether statin use could lead to better outcomes among i…
View article: Alternation of psychological resilience may moderate mentalization toward mental health conditions from macro- and microstructure aspects
Alternation of psychological resilience may moderate mentalization toward mental health conditions from macro- and microstructure aspects Open
The findings underscore the importance of considering both intrapersonal and interpersonal factors in understanding the interactions between psychological resilience and mental health conditions relevant to brain mechanisms.
View article: Exploring the optimal lower blood pressure boundary during endovascular thrombectomy in patients with large vessel occlusion
Exploring the optimal lower blood pressure boundary during endovascular thrombectomy in patients with large vessel occlusion Open
A SBP range above 130-140 mmHg could potentially serve as a safe lower boundary during EVT, while minimizing BP fluctuations may correlate with improved post-EVT functional outcomes.
View article: Functional Transitions of the Default Mode Network Predict Self-Reported Resilience
Functional Transitions of the Default Mode Network Predict Self-Reported Resilience Open
How the brain maintains stability in its internal states is fundamental to understanding human resilience of psychological states against external perturbations. Here, we evaluated the neurocomputational stability of the default mode netwo…
View article: Statin Use Is Associated With Reduced Heart Failure and Risk of Death in Non-Hodgkin Lymphoma
Statin Use Is Associated With Reduced Heart Failure and Risk of Death in Non-Hodgkin Lymphoma Open
View article: Role of Placenta fibrinogen-like 1 (FGL1) in the Pre-Eclampsia progression: a functional study
Role of Placenta fibrinogen-like 1 (FGL1) in the Pre-Eclampsia progression: a functional study Open
Objective : To study the role of placenta fibrinogen-like 1 (FGL1) during pre-eclampsia (PE) progression. Design : A case-control study combined with the experimental research of the cellular and PE mouse model. Setting : FGL1 is a protein…
View article: Effects of Reishimmune-S, a Fungal Immunomodulatory Peptide Supplement, on the Quality of Life and Circulating Natural Killer Cell Profiles of Patients With Early Breast Cancer Receiving Adjuvant Endocrine Therapy
Effects of Reishimmune-S, a Fungal Immunomodulatory Peptide Supplement, on the Quality of Life and Circulating Natural Killer Cell Profiles of Patients With Early Breast Cancer Receiving Adjuvant Endocrine Therapy Open
Objectives: To evaluate the effects of Reishimmune-S, a fungal immunomodulatory peptide, on the quality of life (QoL) and natural killer (NK) cell subpopulations in patients receiving adjuvant endocrine therapy (ET) for breast cancer (BC).…
View article: Risk of Hemorrhagic Stroke among Patients Treated with High-Intensity Statins versus Pitavastatin-Ezetimibe: A Population Based Study
Risk of Hemorrhagic Stroke among Patients Treated with High-Intensity Statins versus Pitavastatin-Ezetimibe: A Population Based Study Open
High-intensity statin (HIS) is recommended for high-risk patients in current guidelines. However, the risk of hemorrhagic stroke (HS) with HIS is a concern for Asians. Pitavastatin carries pharmacological differences compared with other st…
View article: Comparing Efficacy and Safety Between Patients With Atrial Fibrillation Taking Direct Oral Anticoagulants or Warfarin After Direct Oral Anticoagulant Failure
Comparing Efficacy and Safety Between Patients With Atrial Fibrillation Taking Direct Oral Anticoagulants or Warfarin After Direct Oral Anticoagulant Failure Open
Background An increased risk of recurrent stroke is noted in patients with atrial fibrillation despite direct oral anticoagulant (DOAC) use. We investigated the efficacy and safety of treatment with each of 4 different DOACs or warfarin af…
View article: Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study
Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study Open
Background Neurological disorders are still prevalent in HIV-infected people. We aimed to determine the prevalence of neurological disorders and identify their risk factors in HIV-infected persons in Taiwan. Methods We identified 30,101 HI…
View article: Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating β-catenin
Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating β-catenin Open
View article: Prediction of neurological disorders in HIV-infected persons in Taiwan: a nested case-control study
Prediction of neurological disorders in HIV-infected persons in Taiwan: a nested case-control study Open
Background Neurological disorders are still prevalent in HIV-infected people. We aimed to determine the prevalence of neurological disorders and identify their risk factors in HIV-infected persons in Taiwan. Methods We identified 30,101 HI…
View article: Mediating role of resilience in the relationships of physical activity and mindful self-awareness with peace of mind among college students
Mediating role of resilience in the relationships of physical activity and mindful self-awareness with peace of mind among college students Open
View article: Assessment of Tyrosine Kinase Inhibitors and Survival and Cardiovascular Outcomes of Patients With Non–Small Cell Lung Cancer in Taiwan
Assessment of Tyrosine Kinase Inhibitors and Survival and Cardiovascular Outcomes of Patients With Non–Small Cell Lung Cancer in Taiwan Open
Importance Tyrosine kinase inhibitors (TKIs) have been recognized as the standard treatment for patients with non–small cell lung cancers (NSCLCs) and epidermal growth factor receptor (EGFR) sequence variation. Although TKIs have been repo…
View article: Impact of infection-related admission in patients with heart failure: a 10 years national cohort study
Impact of infection-related admission in patients with heart failure: a 10 years national cohort study Open
View article: Association of Statin Use With Cancer- and Noncancer-Associated Survival Among Patients With Breast Cancer in Asia
Association of Statin Use With Cancer- and Noncancer-Associated Survival Among Patients With Breast Cancer in Asia Open
Importance In addition to protective effects on the cardiovascular system, statins may reduce the risk of breast cancer recurrence owing to potential anti-inflammatory benefits. Given that patients with breast cancer in Asia are relatively…
View article: The Association between Ankle–Brachial Index/Pulse Wave Velocity and Cerebral Large and Small Vessel Diseases in Stroke Patients
The Association between Ankle–Brachial Index/Pulse Wave Velocity and Cerebral Large and Small Vessel Diseases in Stroke Patients Open
(1) Background: The study investigated whether the ankle–brachial index (ABI) and pulse wave velocity (baPWV) could reflect the severity of small vessel disease (SVD) and large artery atherosclerosis (LAA). (2) Methods: A total of 956 cons…
View article: The association between tyrosine kinase inhibitors and fatal arrhythmia in patients with non-small cell lung cancer in Taiwan
The association between tyrosine kinase inhibitors and fatal arrhythmia in patients with non-small cell lung cancer in Taiwan Open
Objective As a standard therapy, tyrosine kinase inhibitors (TKIs) improved survival in patients with non-small cell lung cancer (NSCLC) and epidermal growth factor receptor (EGFR) mutation. However, treatment-related cardiotoxicity, parti…
View article: Hepatic arterial infusion chemotherapy and immune checkpoint inhibitors, alone or in combination, in advanced hepatocellular carcinoma with macrovascular invasion: a single-centre experience in Taiwan
Hepatic arterial infusion chemotherapy and immune checkpoint inhibitors, alone or in combination, in advanced hepatocellular carcinoma with macrovascular invasion: a single-centre experience in Taiwan Open
HAIC combined with ICIs had a superior response of PVTT compared to HAIC alone, and was associated with reduced risk of progression or death. Future studies are needed to address the survival benefit of the combination therapy in advanced …
View article: Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study
Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study Open
Depression is a profound public health concern, yet its etiology remains unclear. A body’s magnesium status and low-grade systemic inflammation are associated with depression. However, the interaction of magnesium status and inflammation o…
View article: Recurrent Ischemic Stroke and Cardiovascular Outcomes in Patients With Atrial Fibrillation With Ischemic Stroke Despite Direct Oral Anticoagulants
Recurrent Ischemic Stroke and Cardiovascular Outcomes in Patients With Atrial Fibrillation With Ischemic Stroke Despite Direct Oral Anticoagulants Open
reventive therapy for cardioembolic stroke in patients with atrial fibrillation is anticoagulation, and current guideline recommends direct oral anticoagulants (DOACs) as alternatives to vitamin K antagonists (VKAs).However, ischemic strok…
View article: The Effects of Post-Acute Care in Patients with Heart Failure in Taiwan: A Single Center Experience.
The Effects of Post-Acute Care in Patients with Heart Failure in Taiwan: A Single Center Experience. Open
By incorporating multidisciplinary healthcare teams, the HF-PAC program improves the guideline- directed medical therapy prescription rate, thus improving patients' cardiac function, physical activity recovery, the quality of life, and als…