Xin‐Sheng Yao
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View article: Association of Hemoglobin to Red Blood Cell Distribution Width Ratio and Total Bone Mineral Density in U.S. Adolescents: The NHANES 2011–2018
Association of Hemoglobin to Red Blood Cell Distribution Width Ratio and Total Bone Mineral Density in U.S. Adolescents: The NHANES 2011–2018 Open
Background: The hemoglobin-to-red-cell distribution width ratio has emerged as a novel prognostic marker in various clinical settings. However, its association with total bone mineral density in adolescents remains inadequately explored. M…
View article: Rapid and non-invasive renal injury diagnosis unlocked by a glimpse into urinary protein particle size and charge
Rapid and non-invasive renal injury diagnosis unlocked by a glimpse into urinary protein particle size and charge Open
Urinary protein, an important marker for early detection of kidney injury, would change in type and content dynamically with the degree of kidney injury due to the particle size and charge selectivity of the glomerular filtration system, m…
View article: Early Diagnosis and Treatment of Kidney Injury: A Focus on Urine Protein
Early Diagnosis and Treatment of Kidney Injury: A Focus on Urine Protein Open
The kidney, an essential excretory organ of the body, performs a series of crucial physiological functions such as waste removal, maintenance of electrolyte and acid–base balance, and endocrine regulation. Due to its rich blood flow and hi…
View article: A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process
A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process Open
The diterpene synthase AfAS was identified from Aspergillus fumigatiaffinis . Its amino acid sequence and—according to a structural model—active site architecture are highly similar to those of the fusicocca‐2,10(14)‐diene synthase PaFS, b…
View article: Goji berry-derived phenylpropionyl phenylethylamine derivatives protect against ethanol-induced hepatic damage
Goji berry-derived phenylpropionyl phenylethylamine derivatives protect against ethanol-induced hepatic damage Open
Goji berry is a famous edible and medicinal substance around the world. In this research, 15 phenylpropionyl phenylethylamine derivatives (1−15), in cluding one new compound (1), were separated and identified from g oji berry. All isolates…
View article: Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from <i>Angelica sinensis</i> and Its Bioinspired Total Synthesis
Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from <i>Angelica sinensis</i> and Its Bioinspired Total Synthesis Open
Angelica sinensis, commonly known as Dong Quai in Europe and America and as Dang-gui in China, is a medicinal plant widely utilized for the prevention and treatment of osteoporosis. In this study, we report the discovery of a new category …
View article: Quality markers screening of traditional Chinese medicine prescriptions based on the multi-factor analysis strategy: Jin-Zhen oral liquid as a case
Quality markers screening of traditional Chinese medicine prescriptions based on the multi-factor analysis strategy: Jin-Zhen oral liquid as a case Open
Background: Jin-Zhen oral liquid (JZOL), a well-known traditional Chinese medicine prescription (TCMp), has extensively been used to treat acute bronchitis in children more than four hundred years in China. However, the current quality con…
View article: C <sub>21</sub> steroidal glycosides from the root bark of <i>Periploca sepium</i> and their NO production inhibitory and cytotoxic activity
C <sub>21</sub> steroidal glycosides from the root bark of <i>Periploca sepium</i> and their NO production inhibitory and cytotoxic activity Open
A series of C21 steroidal glycosides were isolated from the root bark of Periploca sepium, including a new compound, perisepiumoside A1 (1), and six known compounds (2-7). Their structures were elucidated by analysis of HR-ESI-MS, and 1D a…
View article: Supplementary Tables 1-2 from Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis
Supplementary Tables 1-2 from Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis Open
PDF file - 44K, S1. The predicted truncated merlin protein was not detected in Ben-Men-1 cells. S2. IC50 determination of AR-42 in normal meningeal cells. S3. AR-42 treatment increased protein acetylation and decreased p-AKT. S4. Normal me…
View article: Supplementary Tables 1-2 from Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis
Supplementary Tables 1-2 from Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis Open
PDF file - 44K, S1. The predicted truncated merlin protein was not detected in Ben-Men-1 cells. S2. IC50 determination of AR-42 in normal meningeal cells. S3. AR-42 treatment increased protein acetylation and decreased p-AKT. S4. Normal me…
View article: Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don
Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don Open
Allium macrostemon Bunge (AMB) and Allium chinense G. Don (ACGD) are both the medicinal herbs of Allii Macrostemonis Bulbus (also named Xiebai in Chinese) for the treatment of coronary heart disease. However, the similarities and differenc…
View article: Characterization of volatile organic compounds with anti-atherosclerosis effects in Allium macrostemon Bge. and Allium chinense G. Don by head space solid phase microextraction coupled with gas chromatography tandem mass spectrometry
Characterization of volatile organic compounds with anti-atherosclerosis effects in Allium macrostemon Bge. and Allium chinense G. Don by head space solid phase microextraction coupled with gas chromatography tandem mass spectrometry Open
Introduction Allium macrostemon Bge. (AMB) and Allium chinense G. Don (ACGD) are both edible Allium vegetables and named officinal Xiebai (or Allii Macrostemonis Bulbus) in East Asia. Their medicinal qualities involve in lipid lowering and…
View article: Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma
Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma Open
Prostate adenocarcinoma (PRAD) is the most frequent malignancy, and is the second leading cause of death due to cancer in men. Thus, new prognostic biomarkers and drug targets for PRAD are urgently needed. As we know, nuclear receptor Nur7…
View article: Kinetic features of Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula, in rat plasma and intestine content based on its metabolic profile
Kinetic features of Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula, in rat plasma and intestine content based on its metabolic profile Open
Gualou-Xiebai-Banxia decoction (GXB) is a famous classical traditional Chinese medicine (TCM) formula for the treatment of coronary heart disease (CHD, namely chest stuffiness and pain syndrome in Chinese medicine). Compared with Gualou-Xi…
View article: Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening
Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening Open
Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective DNA repair. The anti-tumor activities o…
View article: Visual authentication of steroidal saponins in Allium macrostemon Bge. and Allium chinense G. Don using MALDI-TOF imaging mass spectrometry and their structure activity relationship
Visual authentication of steroidal saponins in Allium macrostemon Bge. and Allium chinense G. Don using MALDI-TOF imaging mass spectrometry and their structure activity relationship Open
Allium macrostemon Bge. (AMB) and Allium chinense G. Don (ACGD), both named Allii Macrostemonis Bulbus or Xiebai in Chinese, belong to the same genus. They are both used as edible vegetables and medicinal herbs for the treatment of atheros…
View article: Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells
Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells Open
Vinigrol is a natural diterpenoid with unprecedented chemical structure, driving great efforts into its total synthesis in the past decades. Despite anti-hypertension and anti-clot ever reported, comprehensive investigations on bioactions …
View article: 10-4-4, A Cardiac Glycoside Block Growth in Cancer Cells via Nuclear Receptor Nur77 Mediated Na+/K+- ATPase Endocytosis
10-4-4, A Cardiac Glycoside Block Growth in Cancer Cells via Nuclear Receptor Nur77 Mediated Na+/K+- ATPase Endocytosis Open
Background Cancer is second only to heart disease as a cause of death. Develop new and more effective treatment strategies for cancer remain a major challenge for human medicine today. Nur77, an orphan member for the nuclear receptor super…
View article: Malayoside, a cardenolide glycoside extracted from Antiaris toxicaria Lesch, induces apoptosis in human non-small lung cancer cells via MAPK-Nur77 signaling pathway
Malayoside, a cardenolide glycoside extracted from Antiaris toxicaria Lesch, induces apoptosis in human non-small lung cancer cells via MAPK-Nur77 signaling pathway Open
Lung cancer is the leading cause of cancer deaths in the world. Non-small cell lung cancer (NSCLC), with poor prognosis and resistance to chemoradiotherapy, is the most common histological type of lung cancer. Therefore, it is necessary to…
View article: Comprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database
Comprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database Open
Background: Yiganmingmu oral liquid (YGMM), a well known over-the-counter (OTC) drug in China, is composed of 12 types of valuable herbal medicines and has been widely used in clinical for the treatment of soreness and weakness of waist an…
View article: Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS
Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS Open
Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidity and mortality of mice infec…