Wei Sheng
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View article: Identification of key genes for heart failure in dilated cardiomyopathy in different populations
Identification of key genes for heart failure in dilated cardiomyopathy in different populations Open
Background Heart failure (HF) represents the end stage of cardiovascular disease and is the leading cause of mortality. The objective of this study was to identify potential biomarkers and elucidate the mechanisms underlying the developmen…
View article: Directed and efficient generation of calretinin interneurons from human pluripotent stem cells
Directed and efficient generation of calretinin interneurons from human pluripotent stem cells Open
Our study presents an efficient protocol for generating calretinin interneurons from hPSCs, offering a valuable tool for investigating the development of calretinin interneurons. This approach holds potential for applications in regenerati…
View article: Spatiotemporal Changes in Extreme Temperature and Associated Large-Scale Climate Driving Forces in Chongqing
Spatiotemporal Changes in Extreme Temperature and Associated Large-Scale Climate Driving Forces in Chongqing Open
Due to global warming, extreme temperature events have become increasingly prevalent, posing significant threats to both socioeconomic development and human safety. While previous studies have extensively examined the influence of individu…
View article: Associations of domestic hard water metrics with the risk of gout incidence and recurrence
Associations of domestic hard water metrics with the risk of gout incidence and recurrence Open
Background Accumulating evidence suggests that domestic hard water is linked to health outcomes, but whether there is a potential association with gout is unknown.To examine the association between domestic hard water and gout incidence an…
View article: Identification of candidate genes harboring pathogenic variants in congenital heart disease and laterality defects in Chinese population
Identification of candidate genes harboring pathogenic variants in congenital heart disease and laterality defects in Chinese population Open
Objective Congenital heart disease (CHD) is often accompanied by laterality defects (LD), giving rise to a severe and intricate form of congenital anomaly. The aim of this study was to explore the genetic etiology of CHD/LD in the Chinese …
View article: Assessing the impact of gout on cancer risk and the role of healthy lifestyles
Assessing the impact of gout on cancer risk and the role of healthy lifestyles Open
Background Conflicting evidence exists on the link between gout and cancer risk, with limited clarity on the impact of healthy lifestyle factors. Methods In the UK Biobank, 7,169 gout patients were matched with 21,507 non-gout controls (1:…
View article: Updates of C-LSAT 2.1 and the development of high-resolution LSAT and DTR datasets
Updates of C-LSAT 2.1 and the development of high-resolution LSAT and DTR datasets Open
High-resolution climate datasets are of critical importance for the comprehension of spatial and temporal variations in climate and hydrology. However, their development is significantly influenced by the availability, density, and quality…
View article: Analysis of influencing factors and establishment of prediction model for successful vaginal delivery after cesarean section
Analysis of influencing factors and establishment of prediction model for successful vaginal delivery after cesarean section Open
Objective To explore the influencing factors of vaginal delivery after cesarean section, establish a predictive model, and identify potential factors for perinatal complications. Materials and methods This is a retrospective analysis of wo…
View article: Balancing Protection and Perception: Does Protected Area Establishment Amplify Local Residents' Sense of Loss from Human-Wildlife Conflicts?
Balancing Protection and Perception: Does Protected Area Establishment Amplify Local Residents' Sense of Loss from Human-Wildlife Conflicts? Open
View article: High Quality Development Paths of Green Finance Empowered by Artificial Intelligence
High Quality Development Paths of Green Finance Empowered by Artificial Intelligence Open
View article: Association of Prenatal Depression With Second to Fourth Digit Ratio in Children Aged 4 and 6 Years
Association of Prenatal Depression With Second to Fourth Digit Ratio in Children Aged 4 and 6 Years Open
Animal studies have indicated that prenatal depression may affect the reproductive development of offspring. The digit ratio has been proposed as a marker of in utero reproductive development. The aim of this study was to explore the assoc…
View article: Where Did That Come From? Sentence-Level Error-Tolerant Attribution
Where Did That Come From? Sentence-Level Error-Tolerant Attribution Open
View article: Analysis of wind loads for a new type of insulated crossing frame in transmission lines
Analysis of wind loads for a new type of insulated crossing frame in transmission lines Open
A composite insulation material crossing frame has been designed to meet the safety requirements of transmission line crossing construction. The upper part of the frame is made of composite materials, which consist of modified polyurethane…
View article: Role of inflammatory cytokines and the gut microbiome in vascular dementia: insights from Mendelian randomization analysis
Role of inflammatory cytokines and the gut microbiome in vascular dementia: insights from Mendelian randomization analysis Open
Background Both inflammatory cytokines and the gut microbiome are susceptibility factors for vascular dementia (VaD). The trends in the overall changes in the dynamics of inflammatory cytokines and in the composition of the gut microbiome …
View article: Association of copy number variation in X chromosome-linked PNPLA4 with heterotaxy and congenital heart disease
Association of copy number variation in X chromosome-linked PNPLA4 with heterotaxy and congenital heart disease Open
Background: Heterotaxy (HTX) is a thoracoabdominal organ anomaly syndrome and commonly accompanied by congenital heart disease (CHD). The aim of this study was to analyze rare copy number variations (CNVs) in a HTX/CHD cohort and to examin…
View article: A novel bioaccessibility-based probabilistic risks assessment of potentially toxic elements (PTEs) in earthworm
A novel bioaccessibility-based probabilistic risks assessment of potentially toxic elements (PTEs) in earthworm Open
Graphical Abstract Probabilistic risk assessment strategy of potentially toxic elements in earthworms based on bioaccessibility and MCS technique.
View article: Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis
Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis Open
The potential function and mechanism of circRNAs in regulating malignant performances of Osteosarcoma (OS) cells have not been well investigated. The expression level of CircLMO7, miR-21-5p and ARHGAP24 were detected by RT-qPCR. The relati…
View article: Progresses in genetic testing in congenital heart disease
Progresses in genetic testing in congenital heart disease Open
Congenital heart disease (CHD) encompasses a range of structural malformations affecting the heart and major blood vessels present at birth. The genetic underpinnings of CHD have long been recognized as pivotal, facilitated by a deeper mol…
View article: Table of Contents
Table of Contents Open
View article: Clinical implications of respiratory ciliary dysfunction in heterotaxy patients with congenital heart disease: elevated risk of postoperative airway complications
Clinical implications of respiratory ciliary dysfunction in heterotaxy patients with congenital heart disease: elevated risk of postoperative airway complications Open
Objective Cardiac surgery in Congenital Heart Disease-Heterotaxy (CHD-HTX) patients often leads to increased postoperative airway complications. Abnormal respiratory ciliary function, resembling primary ciliary dyskinesia, has been observe…
View article: Association Between Serum Glycated Hemoglobin Levels at Early Gestation and the Risk of Subsequent Pregnancy Loss in Pregnant Women Without Diabetes Mellitus: Prospective Cohort Study
Association Between Serum Glycated Hemoglobin Levels at Early Gestation and the Risk of Subsequent Pregnancy Loss in Pregnant Women Without Diabetes Mellitus: Prospective Cohort Study Open
Background As a severe morbidity during pregnancy, the etiology of spontaneous pregnancy loss (SPL) remains largely unknown. Serum glycated hemoglobin (HbA1c) level is an established predictor of SPL risk among women with diabetes, but lit…
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 27/2023
Graphisches Inhaltsverzeichnis: Angew. Chem. 27/2023 Open
…functionalization strategy has been developed for the large-scale preparation of aqueous processable high-quality semiconducting 2D triazine polymers.Intheir Research Article (e202301865), Yuxi Xu et al. demonstrate that the obtained crys…
View article: Analysis of the CHD7 gene mutations in patients of congenital heart disease with extracardiac malformations
Analysis of the CHD7 gene mutations in patients of congenital heart disease with extracardiac malformations Open
The findings here confirm that de novo loss-of-function variants of the CHD7 gene are the genetic cause of familial CHD with extracardiac malformations and the spectrum of pathogenic CHD7 variants in sporadic CHD is expanded.
View article: CX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies
CX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies Open
Advances in the understanding of the tumor microenvironment have led to development of immunotherapeutic strategies, such as chimeric antigen receptor T cells (CAR-Ts). However, despite success in blood malignancies, CAR-T therapies in sol…
View article: Association Between Serum Glycated Hemoglobin Levels at Early Gestation and the Risk of Subsequent Pregnancy Loss in Pregnant Women Without Diabetes Mellitus: Prospective Cohort Study (Preprint)
Association Between Serum Glycated Hemoglobin Levels at Early Gestation and the Risk of Subsequent Pregnancy Loss in Pregnant Women Without Diabetes Mellitus: Prospective Cohort Study (Preprint) Open
BACKGROUND As a severe morbidity during pregnancy, the etiology of spontaneous pregnancy loss (SPL) remains largely unknown. Serum glycated hemoglobin (HbA1c) level is an established predictor of SPL risk among women with diabe…
View article: Sodium alginate/gelatin hydrogels loaded with adipose‐derived mesenchymal stem cells promote wound healing in diabetic rats
Sodium alginate/gelatin hydrogels loaded with adipose‐derived mesenchymal stem cells promote wound healing in diabetic rats Open
Background Chronic refractory wounds are a common complication in diabetic patients. Adipose‐derived mesenchymal stem cells (ASCs) have been shown to play an essential role in diabetic wound repair. Aims To determine whether a composite of…
View article: An X-linked PLXNB3 mutation identified in patients with congenital heart disease with neurodevelopmental disabilities
An X-linked PLXNB3 mutation identified in patients with congenital heart disease with neurodevelopmental disabilities Open
These findings suggest that PLXNB3 and the p.E1440V variant may be related to the pathogenesis of CHD associated with NDD.
View article: Functional analysis of <i>HECA</i> variants identified in congenital heart disease in the Chinese population
Functional analysis of <i>HECA</i> variants identified in congenital heart disease in the Chinese population Open
Background Congenital heart disease (CHD) is a class of cardiovascular defects that includes septal defects, outflow tract abnormalities, and valve defects. Human homolog of Drosophila headcase ( HECA ) is a novel cell cycle regulator whos…
View article: <i>WDR62</i> variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation
<i>WDR62</i> variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation Open
Background Congenital heart disease (CHD) is the most common birth defect and has high heritability. Although some susceptibility genes have been identified, the genetic basis underlying the majority of CHD cases is still undefined. Method…
View article: Maternal HbA1c Over 5·6% in Early Pregnancy Increases Spontaneous Pregnancy Loss: Results from the Shanghai Preconception Cohort
Maternal HbA1c Over 5·6% in Early Pregnancy Increases Spontaneous Pregnancy Loss: Results from the Shanghai Preconception Cohort Open