Explanipedia

Structural Design and Analysis of Bionic Shovel Based on the Geometry of Mole Cricket Forefoot Open

Sisi Lin, Hongyan Sun, Guannan Yan, Kexin Que, Sijia Xu , et al. · 2025

In the mechanized harvesting of root vegetables, loosening is a key factor that restricts harvesting efficiency. Existing mechanical loosening methods have poor loosening effect and high operational resistance. Therefore, more efficient ag…

Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 Open

Hongxing Zheng, Bo Wu, Caixiang Zhuang, Jiesheng Mao, Li Min , et al. · 2025

Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults Open

Bo Wu, Hongxing Zheng, Caixiang Zhuang, Jiesheng Mao, Luo Yuncheng , et al. · 2025

Background Research indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. Nevertheless, the relationship between GHR and the risk of gallbl…

A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm® in healthy Chinese subjects Open

Sisi Lin, Yutao Lou, Rui Hao, Yiming Shao, Jin Yü , et al. · 2024

Purpose The aim of this study was to evaluate the bioequivalence of two formulations of rupatadine (10-mg tablets) under fasting and fed conditions in healthy Chinese subjects. Methods A total of 72 subjects were randomly assigned to the f…

Bioequivalence Study of Tebipenem Pivoxil in Healthy Chinese Adults Open

Rui Hao, Yiming Shao, Sisi Lin, Yi Wu, Bian Li , et al. · 2024

Machining Stability Estimation Based on Semi-empirical Cutting Force Model Incorporating Machine Tool Runout Effects Open

Po-Han Chen, Sisi Lin, Tay–Jyi Lin, Pei‐Zen Chang, Wei‐Chang Li · 2024

Sensitive and rapid detection of tet(X2) ~ tet(X5) by loop-mediated isothermal amplification based on visual OTG dye Open

Guiling Chen, Lulin Chen, Sisi Lin, Congzhu Yang, Huanlin Liang , et al. · 2023

The emergence of tigecycline-resistant tet(X2/X3/X4/X5) genes poses a new threat to the efficacy of anti-infective therapy and the safety of our food and environment. To control the transfer of such genes, a sensitive and rapid molecular m…

LncRNA CYP4A22-AS1 promotes the progression of lung adenocarcinoma through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes Open

Liyao Dong, Lin Zhang, Xinyun Zhao, Hongling Zou, Sisi Lin , et al. · 2023

Objectives Lung adenocarcinoma (LUAD) exhibits a higher fatality rate among all cancer types worldwide, yet the precise mechanisms underlying its initiation and progression remain unknown. Mounting evidence suggests that long non-coding RN…

Pharmacokinetics, safety of a single dose and multiple doses of voriconazole injection of two formulations, in Chinese healthy volunteers Open

Chunqi Huang, Yannan Wang, Yi Wu, Sisi Lin, Rui Hao , et al. · 2022

Voriconazole is a first‐line medicine for treating invasive fungal infections. We evaluated the pharmacokinetics (PK) and safety of single/multiple doses of voriconazole injection of Hailing Pharmaceutical Group (Test, T), an imitation of …

Bioequivalence of Pomalidomide Capsules in Fasting and Fed States in Healthy Male Volunteers: A Randomized, Open, Single‐Dose, Biperiodic, Double‐Crossover Study Open

Yannan Wang, Sisi Lin, Ying Wang, Zhuoyan Wang · 2022

This study evaluated the safety, pharmacokinetic parameters, and bioequivalence (BE) of pomalidomide (POM) capsules (specification: 4 mg) acquired from 2 sponsors (test [T] and reference [R]), under fasting and fed conditions. A single‐cen…

New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma Open

Wu Yi, Tianxin Yang, Sisi Lin, Rui Hao, Jinha Yu , et al. · 2022

Wu Yi,1 Tianxin Yang,2 Sisi Lin,1 Rui Hao,1 Jin Yu,1 Ying Wang,1,3 Xiangming Tong2,4 1Phase I Clinical Research Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, People’s Republic of Ch…

Silencing of functional p53 attenuates NAFLD by promoting HMGB1-related autophagy induction Open

Xuequn Zhang, Yiming Lin, Sisi Lin, Chunxiao Li, Jianguo Gao , et al. · 2020

Evaluation of pharmacokinetics and safety with bioequivalence of Amlodipine in healthy Chinese volunteers: Bioequivalence Study Findings Open

Tongtong Wang, Yannan Wang, Sisi Lin, Fang Lü, Sai Lou , et al. · 2020

Background and Objective Amlodipine, a main series of L‐type calcium channel blockers (CCBs), exerts potent antihypertensive effects. The aim of this trial was to explore the pharmacokinetics (PK) and safety with bioequivalence of orally a…

Correlation analysis for school-age children's height and refractive errors Open

Jiawei Chen, Jiawei Chen, Sisi Lin, Jiayu Zhang, Qiang Wang , et al. · 2018

The prevalence of myopia exhibits an increased tendency with height development in children aged 7-14 years. Additionally, school-age children often develop low or moderate myopia rather than high myopia.

Downregulation of MicroRNA 29a/b exacerbated diabetic retinopathy by impairing the function of Müller cells via Forkhead box protein O4 Open

Jiayu Zhang, Liang Wu, Jiawei Chen, Sisi Lin, Daqiu Cai , et al. · 2018

Background: Diabetic retinopathy is a neurological disease, which can lead to blindness in severe cases. The pathogenesis underlying diabetic retinopathy is unclear. The aim of this study was to explore the role of dysregulated microRNA 29…

Long non-coding RNA MIAT acts as a biomarker in diabetic retinopathy by absorbing <i>miR-29b</i> and regulating cell apoptosis Open

Jiayu Zhang, Maochong Chen, Jiawei Chen, Sisi Lin, Daqiu Cai , et al. · 2017

Diabetic retinopathy (DR) is a complication of diabetes mellitus (DM) and is the leading cause of vision loss globally. However, the pathogenic mechanism and clinical therapy still needs further improvement. The biologic significance of my…

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