Shenghao Tu
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View article: 71999 | Effects of Transcatheter Aortic Valve Replacement on Pre-procedure Mitral or Tricuspid Regurgitation
71999 | Effects of Transcatheter Aortic Valve Replacement on Pre-procedure Mitral or Tricuspid Regurgitation Open
View article: Effects of Simiao Pill on rheumatoid arthritis complicated with interstitial lung disease via the ATX/LPA/LPA1 and RhoA/ROCK2 signaling pathways
Effects of Simiao Pill on rheumatoid arthritis complicated with interstitial lung disease via the ATX/LPA/LPA1 and RhoA/ROCK2 signaling pathways Open
Background: In Traditional Chinese Medicine theory, Simiao Pill represents a traditional herbal formulation used for rheumatoid arthritis (RA) management. Initial research indicates that Simiao Pill might have therapeutic benefits for RA l…
View article: Bidirectional causal association between type 1 diabetes and autoimmune diseases: a Mendelian randomization study
Bidirectional causal association between type 1 diabetes and autoimmune diseases: a Mendelian randomization study Open
Introduction It has been reported that individuals with type 1 diabetes (T1D) are at a higher risk of concomitant occurrence of other autoimmune diseases (AIDs). Currently, there is a lack of research investigating the causal relationship …
View article: Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification
Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification Open
Overall, our findings suggest that the ubiquitination of DPP4 by Mid1 promotes synovial cell proliferation and invasion, exacerbating synovitis in RA. These results reveal a novel mechanism that controls synovial activation, positioning Mi…
View article: Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis
Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is a pleiotropic cytokine that primarily activates the Janus kin…
View article: Dyslipidemia in rheumatoid arthritis: the possible mechanisms
Dyslipidemia in rheumatoid arthritis: the possible mechanisms Open
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, of which the leading cause of death is cardiovascular disease (CVD). The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipop…
View article: Evaluating the effectiveness and safety of acupuncture on serum uric acid in asymptomatic hyperuricemia population: a randomized controlled clinical trial study protocol
Evaluating the effectiveness and safety of acupuncture on serum uric acid in asymptomatic hyperuricemia population: a randomized controlled clinical trial study protocol Open
Background The clinical dangers of asymptomatic hyperuricemia to human health have become increasingly prominent over the past 20 years. Previous studies have shown the potential benefits of acupuncture on uric acid levels in the body. How…
View article: Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin
Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin Open
These findings show that triptolide prevents the key linkages of fibrotic ECM remodeling, including deposition, degradation, cross-linking, and pro-fibrotic feedback and, therefore, has potential therapeutic value for pulmonary fibrosis.
View article: T peripheral helper cells in autoimmune diseases: What do we know?
T peripheral helper cells in autoimmune diseases: What do we know? Open
The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they wer…
View article: Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer
Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer Open
Colorectal cancer (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer-related death. In recent years, the relationship between gut microbiota and CRC has attracted increasing attention from researc…
View article: Simiao pill attenuates collagen-induced arthritis and bleomycin-induced pulmonary fibrosis in mice by suppressing the JAK2/STAT3 and TGF-β/Smad2/3 signalling pathway
Simiao pill attenuates collagen-induced arthritis and bleomycin-induced pulmonary fibrosis in mice by suppressing the JAK2/STAT3 and TGF-β/Smad2/3 signalling pathway Open
SM can not only effectively improve joint inflammation by JAK2/STAT3 Pathway but also inhibit pulmonary fibrosis by TGF-β/SMAD2/3. The fibrosis induced by CIA-BLM model was more stable and obvious than that induced by CIA model alone.
View article: Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism
Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism Open
The prevalence of metabolic syndrome (MetS) is drastically growing worldwide, resulting in MetS-associated kidney disease. According to traditional theories, preventing blood pressure, lipid, glycose, and obesity and improving insulin resi…
View article: A diagnostic challenge of mysterious bone pain caused by tumor-induced osteomalacia with multiple tumors: a case report
A diagnostic challenge of mysterious bone pain caused by tumor-induced osteomalacia with multiple tumors: a case report Open
Tumor-induced osteomalacia (TIO); gallium-68 dotatate positron emission tomography/computed tomography (68Ga-DOTATATE PET/CT); phosphaturic mesenchymal tumor (PMTs); weakness; case report.
View article: Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization Open
NF-κB and PPARγ regulating M1 and M2 macrophage polarization and subsequent secretion of pro-inflammatory and anti-inflammatory cytokines are the underlying mechanisms of WTD that ameliorate RA synovial inflammation.
View article: Potential molecular mechanisms of Ermiao san in the treatment of hyperuricemia and gout based on network pharmacology with molecular docking
Potential molecular mechanisms of Ermiao san in the treatment of hyperuricemia and gout based on network pharmacology with molecular docking Open
A network pharmacology integrated molecular docking strategy was used to predict the underlying molecular mechanism of Ermiao san in the treatment of hyperuricemia and gout. Traditional Chinese medicine systems pharmacology (TCMSP) databas…
View article: Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil?
Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil? Open
The occurrence and development of rheumatoid arthritis (RA) is regulated by numerous cytokines. Interleukin 27 (IL-27) is a soluble cytokine that exerts biological effects by regulating the Janus tyrosine kinase (JAK)/signal transducer and…
View article: MicroRNA-181a regulates Treg functions via TGF-β1/Smad axis in the spleen of mice with acute gouty arthritis induced by MSU crystals
MicroRNA-181a regulates Treg functions via TGF-β1/Smad axis in the spleen of mice with acute gouty arthritis induced by MSU crystals Open
Regulatory T cells (Tregs) play critical roles in restricting inflammatory pathogenesis and limiting undesirable Th2 response to environmental allergens. However, the role of miR-181a in regulating acute gouty arthritis (AGA) and Treg func…
View article: SIRT1: A Potential Therapeutic Target in Autoimmune Diseases
SIRT1: A Potential Therapeutic Target in Autoimmune Diseases Open
The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide, and the identification of novel therapeutic strategies for prevention and treatment is urgently needed. Sirtuin 1 (SIRT1), a member of the class III f…
View article: Rheumatic Manifestations and Diseases From Immune Checkpoint Inhibitors in Cancer Immunotherapy
Rheumatic Manifestations and Diseases From Immune Checkpoint Inhibitors in Cancer Immunotherapy Open
Immune checkpoint inhibitors (ICIs), which can enhance antitumor immunity and inhibit cancer growth, have revolutionized the treatment of multiple cancers and dramatically decreased mortality. However, treatment with ICIs is directly assoc…
View article: General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19
General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19 Open
To establish risk-classification-based early screening and to introduce early prevention protocol of glucocorticoid-induced osteonecrosis will be of clinical significance in favor of improved prognosis of COVID-19.
View article: A comprehensive transcriptomic analysis of alternate interferon signaling pathways in peripheral blood mononuclear cells in rheumatoid arthritis
A comprehensive transcriptomic analysis of alternate interferon signaling pathways in peripheral blood mononuclear cells in rheumatoid arthritis Open
Interferon (IFN) signaling pathways play crucial roles in the pathogenesis of rheumatoid arthritis (RA). Prior studies have mainly studied mixed alterations in the IFN signaling pathway in RA, but these studies have not been sufficient to …
View article: Exploring the Clinical Characteristics of COVID-19 Clusters Identified Using Factor Analysis of Mixed Data-Based Cluster Analysis
Exploring the Clinical Characteristics of COVID-19 Clusters Identified Using Factor Analysis of Mixed Data-Based Cluster Analysis Open
The COVID-19 outbreak has brought great challenges to healthcare resources around the world. Patients with COVID-19 exhibit a broad spectrum of clinical characteristics. In this study, the Factor Analysis of Mixed Data (FAMD)-based cluster…
View article: Hyperprogressive Disease in Cancers Treated With Immune Checkpoint Inhibitors
Hyperprogressive Disease in Cancers Treated With Immune Checkpoint Inhibitors Open
Immunotherapy, which takes advantage of the immune system to eliminate cancer cells, has been widely studied and applied in oncology. Immune checkpoint inhibitors (ICIs) prevent the immune system from being turned off before cancer cells a…
View article: Potential Implications of Quercetin in Autoimmune Diseases
Potential Implications of Quercetin in Autoimmune Diseases Open
Autoimmune diseases are a worldwide health problem with growing rates of morbidity, and are characterized by breakdown and dysregulation of the immune system. Although their etiology and pathogenesis remain unclear, the application of diet…
View article: He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study
He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study Open
Combination therapy using Western and traditional Chinese medicines has shown notable effects on coronavirus disease 2019 (COVID-19). The He-Jie-Shen-Shi decoction (HJSS), composed of Bupleurum chinense DC., Scutellaria baicalensis Georgi,…
View article: Positive effects of Lianhuaqingwen granules in COVID-19 patients: A retrospective study of 248 cases
Positive effects of Lianhuaqingwen granules in COVID-19 patients: A retrospective study of 248 cases Open
View article: A novel PMP22 insertion mutation causing Charcot–Marie–Tooth disease type 3
A novel PMP22 insertion mutation causing Charcot–Marie–Tooth disease type 3 Open
Rationale: Charcot–Marie–Tooth disease (CMT) is a group of hereditary neuropathies with clinical features of muscle atrophy, sensory loss, and foot deformities. CMT is related to a number of genes, such as peripheral myelin protein 22 gene…
View article: Reactive Oxygen Species in Autoimmune Cells: Function, Differentiation, and Metabolism
Reactive Oxygen Species in Autoimmune Cells: Function, Differentiation, and Metabolism Open
Accumulated reactive oxygen species (ROS) directly contribute to biomacromolecule damage and influence various inflammatory responses. Reactive oxygen species act as mediator between innate and adaptive immune cells, thereby influencing th…
View article: Si Miao San Attenuates Inflammation and Oxidative Stress in Rats with CIA via the Modulation of the Nrf2/ARE/PTEN Pathway
Si Miao San Attenuates Inflammation and Oxidative Stress in Rats with CIA via the Modulation of the Nrf2/ARE/PTEN Pathway Open
Objective. Si Miao San (SMS) is a traditional Chinese formula used in China to treat rheumatic diseases. To date, its mechanism in rheumatoid arthritis (RA) treatment is uncertain. Our study aims to assess the antiarthritic effects of SMS …
View article: Characteristics of Viral Shedding in Respiratory Samples and Specific Antibodies Production in 564 COVID-19 Patients
Characteristics of Viral Shedding in Respiratory Samples and Specific Antibodies Production in 564 COVID-19 Patients Open