Shenghe Tian
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View article: Stem cell transplantation rescued a primary open-angle glaucoma mouse model
Stem cell transplantation rescued a primary open-angle glaucoma mouse model Open
Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if transplanted stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human …
View article: BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes Open
Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic nerve (ON) severely affects vision. Understanding the molecular mechanism of oligodendrocyte progenitor cell (OPC) differentiation into mature oligoden…
View article: Author response: Stem cell transplantation rescued a primary open-angle glaucoma mouse model
Author response: Stem cell transplantation rescued a primary open-angle glaucoma mouse model Open
View article: Stem Cell Transplantation Rescued A Primary Open-Angle Glaucoma Mouse Model
Stem Cell Transplantation Rescued A Primary Open-Angle Glaucoma Mouse Model Open
Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if exogenous stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human tra…
View article: KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27
KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27 Open
Collectively, these results demonstrate that KLF4 regulates CE cell cycle progression by suppressing canonical TGF-β signaling and overcomes the undesirable concomitant decrease in TGF-β-dependent CDK inhibitors p16 and p27 expression by d…
View article: Bacteria induce autophagy in a human ocular surface cell line
Bacteria induce autophagy in a human ocular surface cell line Open
View article: Lgr5 <sup>+</sup> amacrine cells possess regenerative potential in the retina of adult mice
Lgr5 <sup>+</sup> amacrine cells possess regenerative potential in the retina of adult mice Open
Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult…
View article: Genetic Vaccines To Potentiate the Effective CD103+ Dendritic Cell–Mediated Cross-Priming of Antitumor Immunity
Genetic Vaccines To Potentiate the Effective CD103+ Dendritic Cell–Mediated Cross-Priming of Antitumor Immunity Open
The development of effective cancer vaccines remains an urgent, but as yet unmet, clinical need. This deficiency is in part due to an incomplete understanding of how to best invoke dendritic cells (DC) that are crucial for the induction of…