Shenghe Deng
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View article: Epithelial membrane protein 1 drives hepatic stellate cell activation via the TLN1/FAK cascade in MASLD donor liver transplantation
Epithelial membrane protein 1 drives hepatic stellate cell activation via the TLN1/FAK cascade in MASLD donor liver transplantation Open
View article: A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1 Open
View article: Engineering Inorganic Nanoparticles to Induce Cuproptosis: A New Strategy for Cancer Therapy
Engineering Inorganic Nanoparticles to Induce Cuproptosis: A New Strategy for Cancer Therapy Open
Cuproptosis is a newly identified type of copper (Cu)-dependent programmed cell death (PCD), triggered when Cu directly interacts with the lipoylated components of the tricarboxylic acid (TCA) cycle, and it has shown significant antitumor …
View article: Analysis of Immune Cell Infiltration Distribution and Prognostic Value in Obstructive Colorectal Cancer
Analysis of Immune Cell Infiltration Distribution and Prognostic Value in Obstructive Colorectal Cancer Open
Objective: This study aims to determine how intestinal obstruction influences the tumor immune microenvironment (TIME) and its impact on prognosis in colorectal cancer (CRC). Methods: Immune cell densities (CD4+, CD8+, CD20+, CD68+) within…
View article: Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1 Open
Tumor necrosis factor α (TNFα) maintains homeostasis through promoting cell survival or cell death; however, how this process is regulated by metabolic pathways remains largely unknown. Here, we identify adenosine kinase (ADK), the key enz…
View article: Identifying the minimum number of retrieved lymph nodes in node-negative duodenal adenocarcinoma: a retrospective analysis of the real-world data and SEER database
Identifying the minimum number of retrieved lymph nodes in node-negative duodenal adenocarcinoma: a retrospective analysis of the real-world data and SEER database Open
Background: An adequate number of retrieved lymph nodes (rLNs) are crucial for accurate N-stage assessment; however, the optimal number of rLNs for duodenal adenocarcinoma remains undefined. This study aims to determine the minimum number …
View article: Association between triglyceride-glucose index and obstructive sleep apnea severity in hypertensive patients with co-existing OSA: a cross-sectional study
Association between triglyceride-glucose index and obstructive sleep apnea severity in hypertensive patients with co-existing OSA: a cross-sectional study Open
Study objectives To evaluate the association between the triglyceride-glucose (TyG) index and obstructive sleep apnea (OSA) severity in hypertensive patients with comorbid OSA, particularly in non-obese subgroups. Methods This cross-sectio…
View article: Enhancing remanent magnetization of injectable hydrogels improves realtime transluminal localization of tumor in hollow soft viscera
Enhancing remanent magnetization of injectable hydrogels improves realtime transluminal localization of tumor in hollow soft viscera Open
View article: Multi-omics analysis reveals disrupted gut microbiota and metabolism in gastric cancer patients with high SIRI
Multi-omics analysis reveals disrupted gut microbiota and metabolism in gastric cancer patients with high SIRI Open
High SIRI levels are associated with poorer prognosis in GC patients. Significant differences in gut microbiota and metabolites were observed across different SIRI levels in GC patients, showing their potential as non-invasive markers for …
View article: The Dual Role of TRADD in Liver Disease: From Cell Death Regulation to Inflammatory Microenvironment Remodeling
The Dual Role of TRADD in Liver Disease: From Cell Death Regulation to Inflammatory Microenvironment Remodeling Open
The global burden of liver diseases continues to rise, encompassing diverse pathologies such as viral hepatitis, alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatocellular c…
View article: Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance
Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance Open
The intratumoral microbiota, as an important component of the tumor microenvironment, is increasingly recognized as a key factor in regulating responses to cancer immunotherapy. Recent studies have revealed that the intratumoral microbiota…
View article: Supplementary Excel 2 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Supplementary Excel 2 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Nontargeted metabolomics analysis of OCRC and CRC tissues
View article: Figure S1 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S1 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S1: OCRC and CRC differed substantially in clinicopathology, with poorer prognoses in OCRC. (A) Comparative analysis of OS and DFS in CRC (n=1272) and OCRC (n=198) patients. (B) Clinicopathological characteristics of CRC (n=1272) an…
View article: Figure S15 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S15 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S15: Screening of natural compounds targeting the NF-κB pathway. (A-B) Validations of potential natural compounds via qRT‒PCR (A) and Western blotting (B). (C-D) ELISA assay confirmed that vanillylacetone (C) significantly inhibited…
View article: Figure S12 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S12 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S12: PA stimulates NF-to-mCAF activation by stimulating CRC cells to secrete CSF-1, TGF-β1, and CXCL8. (A) Volcano plot of differentially expressed genes in SW480 cells after PA stimulation. (B-C) KEGG (B) and GO (C) enrichment anal…
View article: Table S1 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Table S1 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
List of antibodies and inhibitor used in the experiment.
View article: Figure S6 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S6 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S6: OCRC- and CRC-derived CAFs exhibited significant functional differences. (A) The function of ECM-related proteins, matrix metalloproteinases, LOX, and tissue inhibitor of matrix metalloproteinases secretion by CAFs from OCRC and…
View article: Table S2 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Table S2 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
The primer sequences for RT-qPCR.
View article: Figure S7 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S7 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S7: OCRC and CRC differed metabolically, with palmitic acid levels being elevated in OCRC. (A) Analysis of serum lipids indexes, glucose, arterial calcification and atherosclerosis in 150 matched pairs of OCRC and CRC patients. (B) …
View article: Figure S10 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S10 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S10: PA does not directly promote NF-to-mCAF activation. (A) CCK-8 assay determining the optimal concentration of CAFs stimulated by PA. (B) CCK-8 assay analysis of the relationship between PA stimulation and CAFs proliferation. (C)…
View article: Figure S17 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S17 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S17: Animal models validated vanillylacetone inhibited PA-induced cytokine secretion and NF-to-CAF/mCAF activation. (A-B) Measurement of CSF-1, CXCL8, and TGF-β1 levels in CRC subcutaneous tumors and serum of C57BL/6 (A) and BALB/c …
View article: Figure S14 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S14 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S14: PA promotes mCAF activation and regulates cytokine secretion via the NF-κB pathway. (A) Immunofluorescence staining detection of mCAFs in subcutaneous and orthotopic CRC models of C57BL/6 and Apcmin/+ mice, green: FN1, red: α-S…
View article: Figure S13 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S13 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S13: Dietary PA intervention promoted CAF activation, enhancing ECM stiffness and tumor proliferation. (A) Effects of PA-enriched high-fat diet on the growth of subcutaneous tumors of C57BL/6 (n = 20) and BALB/c mice (n = 10), and o…
View article: Figure S16 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S16 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S16: Vanillylacetone inhibited PA-induced CAF activation, ECM stiffness, and OCRC progression. (A) Tumor growth and mass measurements in C57BL/6 and BALB/c mice subcutaneous tumors following vanillylacetone treatment. (B-C) Analysis…
View article: Figure S11 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S11 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S11: PA promoted CAFs function and facilitated partial NF-to-mCAF activation by stimulated CRC cells. (A) CCK-8 assay to explore the optimal concentration of CRC cells stimulated by PA. (B) Oil Red O staining visualizing lipid dropl…
View article: Figure S5 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S5 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S5: OCRC and CRC differed in stromal cells, with significantly more matrix CAFs in OCRC. (A) Isolated and identified the primary CAFs from fresh OCRC and CRC tissues, red: Vimentin, green: α-SMA, (Scale bars = 100μm). (B) KEGG and G…
View article: Data from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Data from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Obstructions can occur during any stage of colorectal cancer and correspond with poor prognosis. Obstructive colorectal cancer (OCRC) is harder and exhibits increased tumor budding and proliferation of myofibroblasts compared with nonobstr…
View article: Figure S4 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S4 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S4: Functional analyses on α-SMA-positive CAFs and NFs from OCRC, CRC, and normal tissues. (A) KEGG and GO enrichment analysis of α-SMA positive cells from OCRC and CRC tissues. (B) KEGG and GO enrichment analysis of α-SMA positive …
View article: Supplementary Excel 1 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Supplementary Excel 1 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Differential expression analysis of the transcriptome of NF and CAF in OCRC, CRC and normal SMA positive tissues
View article: Figure S3 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
Figure S3 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer Open
Figure S3: Analysis of stromal cell content in the OCRC and CRC tumor microenvironment. (A) Semi-quantitative analysis of epithelial cells, CAFs, microvessels, and lymphatic vessels in OCRC and CRC stromal regions. (B) Tissue multiplex imm…