Shu‐Yi Liao
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View article: Determinants of Forest Travelers’ Environmentally Responsible Behaviors and Willingness to Pay
Determinants of Forest Travelers’ Environmentally Responsible Behaviors and Willingness to Pay Open
This study investigated the interrelationships among Lifestyles of Health and Sustainability (LOHASs), recreational benefits, and environmentally responsible behaviors (ERBs) of visitors to the Xitou Forest Recreation Area in Taiwan and es…
View article: Label recognition on metal surfaces in semiconductor industry by YOLO object detection model
Label recognition on metal surfaces in semiconductor industry by YOLO object detection model Open
View article: Mechanism of antiphospholipid antibody-mediated thrombosis in antiphospholipid syndrome
Mechanism of antiphospholipid antibody-mediated thrombosis in antiphospholipid syndrome Open
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of thrombotic or obstetrical events in patients with persistent antiphospholipid antibodies (aPL). Thrombotic events, the primary pathological hallmar…
View article: Single Cell Transcriptome Signatures of Sarcoidosis in Lung Immune Cell Populations
Single Cell Transcriptome Signatures of Sarcoidosis in Lung Immune Cell Populations Open
Rationale To identify cell specific molecular changes associated with sarcoidosis risk and progression, we aimed to characterize the cellular composition, gene expression patterns, and cell-cell interactions in BAL cells from patients with…
View article: Unsupervised Local Editing of Ocular Images via Reverse-attention block
Unsupervised Local Editing of Ocular Images via Reverse-attention block Open
Predicting the postoperative appearance after strabismus surgery is of great sig-nificance for improving patients' understanding of the postoperative outcomes, enhancing communication between doctors and patients, and alleviating preopera-…
View article: The textures of sarcoidosis: quantifying lung disease through variograms
The textures of sarcoidosis: quantifying lung disease through variograms Open
Objective . Sarcoidosis is a granulomatous disease affecting the lungs in over 90% of patients. Qualitative assessment of chest CT by radiologists is standard clinical practice and reliable quantification of disease from CT would support o…
View article: Multi-omic signatures of sarcoidosis and progression in bronchoalveolar lavage cells
Multi-omic signatures of sarcoidosis and progression in bronchoalveolar lavage cells Open
View article: Succinate coenzyme A ligase β‐like protein from <i>Trichinella spiralis</i> is a potential therapeutic molecule for allergic asthma
Succinate coenzyme A ligase β‐like protein from <i>Trichinella spiralis</i> is a potential therapeutic molecule for allergic asthma Open
Background For decades, studies have demonstrated the anti‐inflammatory potential of proteins secreted by helminths in allergies and asthma. Previous studies have demonstrated the immunomodulatory capabilities of Succinate Coenzyme A ligas…
View article: The textures of sarcoidosis: quantifying lung disease through variograms
The textures of sarcoidosis: quantifying lung disease through variograms Open
Objective Sarcoidosis is a granulomatous disease affecting the lungs in over 90% of patients. Qualitative assessment of chest CT by radiologists is standard clinical practice and reliable quantification of disease from CT would support ong…
View article: Genome and Transcriptome-Wide Association Study of Fibrotic Sarcoidosis in European Americans
Genome and Transcriptome-Wide Association Study of Fibrotic Sarcoidosis in European Americans Open
"Genome and Transcriptome-Wide Association Study of Fibrotic Sarcoidosis in European Americans." American Journal of Respiratory and Critical Care Medicine, 209(3), pp. 334–337
View article: COPD with elevated sputum group 2 innate lymphoid cells is characterized by severe disease
COPD with elevated sputum group 2 innate lymphoid cells is characterized by severe disease Open
Rationale Pulmonary innate immune cells play a central role in the initiation and perpetuation of chronic obstructive pulmonary disease (COPD), however the precise mechanisms that orchestrate the development and severity of COPD are poorly…
View article: Vaccine-elicited B- and T-cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients
Vaccine-elicited B- and T-cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients Open
Background While vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides significant protection from coronavirus disease 2019, the protection afforded to individuals with chronic lung disease is less well …
View article: Genome-wide association study identifies multiple HLA loci for sarcoidosis susceptibility
Genome-wide association study identifies multiple HLA loci for sarcoidosis susceptibility Open
Sarcoidosis is a complex systemic disease. Our study aimed to (1) identify novel alleles associated with sarcoidosis susceptibility; (2) provide an in-depth evaluation of HLA alleles and sarcoidosis susceptibility and (3) integrate genetic…
View article: Vaccine-elicited B and T cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients
Vaccine-elicited B and T cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients Open
The protection afforded by vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to individuals with chronic lung disease is not well established. To understand how chronic lung disease impacts SARS-CoV-2 vaccine…
View article: Multi-Omic Signatures of Sarcoidosis and Progression in Bronchoalveolar Lavage Cells
Multi-Omic Signatures of Sarcoidosis and Progression in Bronchoalveolar Lavage Cells Open
Introduction Sarcoidosis is a heterogeneous, granulomatous disease that can prove difficult to diagnose, with no accurate biomarkers of disease progression. Therefore, we profiled and integrated the DNA methylome, mRNAs, and microRNAs to i…
View article: Radiomic Profiling of Chest CT in a Cohort of Sarcoidosis Cases
Radiomic Profiling of Chest CT in a Cohort of Sarcoidosis Cases Open
Background High resolution computed tomography (HRCT) of the chest is increasingly used in clinical practice for sarcoidosis. Visual assessment of chest HRCTs in patients with sarcoidosis has high inter- and intra-rater variation. Radiomic…
View article: Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity
Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity Open
Chronic beryllium disease (CBD) is a Th1 granulomatous lung disease preceded by sensitization to beryllium (BeS). We profiled the methylome, transcriptome, and selected proteins in the lung to identify molecular signatures and networks ass…
View article: Predictive characteristics of prolonged symptoms and seroconversion in ambulatory patients recovering from SARS-CoV-2 infection
Predictive characteristics of prolonged symptoms and seroconversion in ambulatory patients recovering from SARS-CoV-2 infection Open
Introduction: As an increasing number of patients present for ambulatory care following acute COVID-19, we set out to characterize and identify clinical predictors of prolonged symptoms and antibody seroconversion. We hypothesized that pat…
View article: SARS-CoV-2 mRNA Vaccine Antibody Response in Patients with Asthma Receiving Biologic Therapy: A Real-World Analysis
SARS-CoV-2 mRNA Vaccine Antibody Response in Patients with Asthma Receiving Biologic Therapy: A Real-World Analysis Open
"SARS-CoV-2 mRNA Vaccine Antibody Response in Asthma Patients with Biologic Therapy after Second and Booster Dose: A Real-world Analysis." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –
View article: Clinical phenotyping in sarcoidosis using cluster analysis
Clinical phenotyping in sarcoidosis using cluster analysis Open
Background Most phenotyping paradigms in sarcoidosis are based on expert opinion; however, no paradigm has been widely adopted because of the subjectivity in classification. We hypothesized that cluster analysis could be performed on commo…
View article: Characteristics and outcomes of ambulatory patients with suspected COVID-19 at a respiratory referral center
Characteristics and outcomes of ambulatory patients with suspected COVID-19 at a respiratory referral center Open
View article: Impaired SARS-CoV-2 mRNA Vaccine Antibody Response in Chronic Medical Conditions
Impaired SARS-CoV-2 mRNA Vaccine Antibody Response in Chronic Medical Conditions Open
View article: Competitive Intelligence Gathering in Strategic Decision Making
Competitive Intelligence Gathering in Strategic Decision Making Open
Over recent years, due to globalization and the increasingly fierce market competition environment, organizations have started to capitalize on the significant use of competitive intelligence (CI) systems to provide valuable information re…
View article: The landscape of transcriptomic and proteomic studies in sarcoidosis
The landscape of transcriptomic and proteomic studies in sarcoidosis Open
Multiple overlapping pathways are identified in tissue, BAL cells, PBMCs and a sarcoidosis in vitro granuloma model. Inferences from omic studies are constrained by small sample sizes. Studies comparing differences between sarcoi…
View article: Identification of early and intermediate biomarkers for ARDS mortality by multi-omic approaches
Identification of early and intermediate biomarkers for ARDS mortality by multi-omic approaches Open
View article: Clinical Phenotyping In Sarcoidosis Using Cluster Analysis
Clinical Phenotyping In Sarcoidosis Using Cluster Analysis Open
Background Most phenotyping paradigms in sarcoidosis are based on expert opinion; however, no paradigm has been widely adopted because of the subjectivity in classification. We hypothesized that cluster analysis could be performed on commo…
View article: Impaired SARS-CoV-2 mRNA vaccine antibody response in chronic medical conditions: a real-world data analysis
Impaired SARS-CoV-2 mRNA vaccine antibody response in chronic medical conditions: a real-world data analysis Open
This study is to investigate whether certain medical conditions may impair antibody response to the mRNA vaccines. In this unique study, participants were drawn from patients in National Jewish Health, a pulmonary specialty outpatient clin…
View article: L‐arginine as a potential GLP‐1‐mediated immunomodulator of Th17‐related cytokines in people with obesity and asthma
L‐arginine as a potential GLP‐1‐mediated immunomodulator of Th17‐related cytokines in people with obesity and asthma Open
Obesity is considered as a risk factor for COVID‐19 with insulin resistance and increased production of inflammatory cytokines as likely mechanisms. Glucagon‐like peptide‐1 (GLP‐1) agonists and inhaled nitric oxide are proposed therapeutic…
View article: Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases
Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases Open
scRNA-seq characterised macrophage transcriptional and chromatin accessibility profiles in BAL cells in granulomatous lung diseases, chronic beryllium disease and sarcoidosis, and identified signatures of disease progression in sarcoido…
View article: Characteristics and Outcomes of Ambulatory Patients with Suspected COVID-19 at a Respiratory Referral Center
Characteristics and Outcomes of Ambulatory Patients with Suspected COVID-19 at a Respiratory Referral Center Open