Shengju Yang
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View article: New insights into microRNA in dermatological diseases
New insights into microRNA in dermatological diseases Open
MicroRNAs (miRs) are a class of non-coding RNA molecules that regulate gene expression post-transcriptionally. MiRs, as translational repression and/or degradation of target messenger RNAs, are critical regulators of various physiological …
View article: PRR14 acts a novel oncogene activating the PI3K signal pathway in human cutaneous squamous cell carcinoma
PRR14 acts a novel oncogene activating the PI3K signal pathway in human cutaneous squamous cell carcinoma Open
Proline rich protein 14 (PRR14) is considered as a new component of the nuclear fiber layer, it may be a key molecule in mediating nuclear morphological changes and functional changes in tumorigenesis. But, it's still unclear in human cuta…
View article: Inhibitory Activity of Pyrroloisoxazolidine Derivatives against <i>Chlamydia trachomatis</i>
Inhibitory Activity of Pyrroloisoxazolidine Derivatives against <i>Chlamydia trachomatis</i> Open
The obligate intracellular bacterium Chlamydia trachomatis is a group of worldwide human pathogens that can lead to serious reproductive problems. The frequent clinical treatment failure promoted the development of novel antichlamydial age…
View article: SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement
SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement Open
Sirtuin 3 (SIRT3) plays a vital role in several dermatological diseases. However, the role and detailed mechanism of SIRT3 in diabetic wound healing are unknown well yet. To explore possible involvement of SIRT3 and necroptosis in diabetic…
View article: Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin
Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin Open
As the most abundant natural flavonoid in rattan tea, dihydromyricetin (DMY) has shown a wide range of pharmacological effects. In addition to the general characteristics of flavonoids, DMY has the effects of cardioprotection, anti-diabete…
View article: Protective effects and mechanisms of hydrogen sulfide on isoproterenol-induced cardiac hypertrophy in mice
Protective effects and mechanisms of hydrogen sulfide on isoproterenol-induced cardiac hypertrophy in mice Open
Background Hydrogen sulfide (H2S) is a gasotransmitter with a variety of cardiovascular protective effects. Sirtuin 3 (sirtuin 3, SIRT3) is closely related to mitochondrial function and oxidative stress. The aim of this study was to invest…
View article: Hydrogen sulfide promotes skin wound healing via inhibitory of oxidative stress
Hydrogen sulfide promotes skin wound healing via inhibitory of oxidative stress Open
Background Hydrogen sulfide (H2S) is an important gasotransmitter involved in physiological function. However, the role of H2S on skin wound healing and the detailed mechanisms were not known well.
View article: Enhanced expression of advanced glycosylation end products in skin of diabetic mice and the influence on collagen fibers
Enhanced expression of advanced glycosylation end products in skin of diabetic mice and the influence on collagen fibers Open
Background To investigate the expressions of advanced glycosylation end products (AGE) in skin of mice with diabetes mellitus (DM) for different durations, and to evaluate their influence on collagen fibers.