Explanipedia

Rodent adapted marburg viruses are lethal in ferrets Open

Zachary Schiffman, Lauren Garnett, Kaylie N. Tran, Jonathan Audet, Kevin Tierney , et al. · 2025

Ferrets are highly susceptible to infection with several orthoebolaviruses, including Ebola virus (EBOV), yet they are refractory to infection with the orthomarburgviruses, Marburg virus (MARV) and Ravn virus. This study sought to investig…

Primary Ewing Sarcoma Within an Autosomal Dominant Polycystic Kidney: A Case Report Open

Shihua He, Jonathan J. Davick, Prerna Rastogi, Sarat Kuppachi · 2025

Ewing sarcoma, that originates from neuroectoderm, is typically encountered in the bone and soft tissue of children and young adults and rarely presents as a primary renal tumor. Autosomal dominant polycystic kidney disease, which is the m…

Deep sequencing of serially passaged Sudan virus in guinea pigs uncovers adaptive mutations Open

Karla Emeterio, Jonathan Audet, Wenjun Zhu, Anders Leung, Helene Schulz , et al. · 2025

Orthoebolaviruses are non-segmented, negative sense RNA viruses that make up the genus Orthoebolavirus in the family Filoviridae. Sudan virus (SUDV) is a highly pathogenic orthoebolavirus that causes severe disease in humans.…

Lightweight QR code detection network for digital tracking of cigar sales Open

Rui Sun, Wenguang Ma, Xianghua Li, Shihua He, Degang Zhang , et al. · 2025

Quercetin inhibits SARS-CoV-2 infection and prevents syncytium formation by cells co-expressing the viral spike protein and human ACE2 Open

Annie Roy, Michael C. W. Chan, Logan Banadyga, Shihua He, Wenjun Zhu , et al. · 2024

Background Several in silico studies have determined that quercetin, a plant flavonol, could bind with strong affinity and low free energy to SARS-CoV-2 proteins involved in viral entry and replication, suggesting it could block infection …

AAV-Vectored Expression of Marburg Virus–Neutralizing Antibody MR191 Provides Complete Protection From Challenge in a Guinea Pig Model Open

Amira D. Rghei, Wenguang Cao, Shihua He, Jordyn A. Lopes, Nicole Zielinska , et al. · 2023

Although there are no approved countermeasures available to prevent or treat disease caused by Marburg virus (MARV), potently neutralizing monoclonal antibodies (mAbs) derived from B cells of human survivors have been identified. One such …

The rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs Open

Wenguang Cao, Shihua He, Guodong Liu, Helene Schulz, Karla Emeterio , et al. · 2023

A Pan-Ebolavirus Monoclonal Antibody Cocktail Provides Protection Against Ebola and Sudan Viruses Open

Guodong Liu, Shihua He, Michael C. W. Chan, Zirui Zhang, Helene Schulz , et al. · 2023

Filoviruses, including ebolaviruses and marburgviruses, can cause severe and often fatal disease in humans. Over the past several years, antibody therapy has emerged as a promising strategy for the treatment of filovirus disease. Here, we …

Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes Open

Xiaofeng Dong, Julia A. Tree, Logan Banadyga, Shihua He, Wenjun Zhu , et al. · 2023

Ebola virus infection can have dramatic effects on the human body which manifest in Ebola virus disease. The outcome of infection is either survival or death and in the former group with the potential of longer-term health consequences and…

The rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs Open

Wenguang Cao, Shihua He, Guodong Liu, Helene Schulz, Karla Emeterio , et al. · 2022

Recombinant vesicular stomatitis viruses (rVSVs) engineered to express heterologous viral glycoproteins have proven to be remarkably effective vaccines. Indeed, rVSV-EBOV, which expresses the Ebola virus (EBOV) glycoprotein, recently recei…

AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge Open

Laura P. van Lieshout, Amira D. Rghei, Wenguang Cao, Shihua He, Geoff Soule , et al. · 2022

Filoviruses cause severe hemorrhagic fever with case fatality rates as high as 90%. Filovirus-specific monoclonal antibodies (mAbs) confer protection in nonhuman primates as late as 5 days after challenge, and FDA-approved mAbs REGN-EB3 an…

A Cloned Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine, PHV01, Protects Guinea Pigs from Lethal Marburg Virus Disease Open

Wenjun Zhu, Guodong Liu, Wenguang Cao, Shihua He, Anders Leung , et al. · 2022

Marburg virus (MARV) is a negative-sense, single-stranded RNA virus that belongs to the Filoviridae family. Despite having caused numerous outbreaks of severe hemorrhagic fever with high case fatality rates, there are still no clinically a…

Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters Open

Bryan D. Griffin, Bryce M. Warner, Mable Chan, Emelissa J. Valcourt, Nikesh Tailor , et al. · 2021

Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease Open

Bryce M. Warner, Lisa A. Santry, Alexander Leacy, Mable Chan, Phuc H. Pham , et al. · 2021

The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Ne…

Role of Key Infectivity Parameters in the Transmission of Ebola Virus Makona in Macaques Open

Marc-Antoine de La Vega, Gary Wong, Haiyan Wei, Shihua He, Alexander Bello , et al. · 2021

Many characteristics associated with Ebola virus disease remain to be fully understood. It is known that direct contact with infected bodily fluids is an associated risk factor, but few studies have investigated parameters associated with …

SARS-CoV-2 infection and transmission in the North American deer mouse Open

Bryan D. Griffin, Mable Chan, Nikesh Tailor, Emelissa J. Mendoza, Anders Leung , et al. · 2021

Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection Open

Bryan D. Griffin, Bryce M. Warner, Mable Chan, Emelissa J. Mendoza, Nikesh Tailor , et al. · 2021

The emergence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resultant pandemic of coronavirus disease 2019 (COVID-19) has led to over one hundred million confirmed infections, greater than three million deaths, an…

Characterization of Ebola Virus Risk to Bedside Providers in an Intensive Care Environment Open

Mia J. Biondi, Lauren Garnett, Alexander Bello, Duane J. Funk, Philippe Guillaume Poliquin , et al. · 2021

Background: The 2014–2016 Ebola outbreak in West Africa recapitulated that nosocomial spread of Ebola virus could occur and that health care workers were at particular risk including notable cases in Europe and North America. These instanc…

Biological activity-based modeling identifies antiviral leads against SARS-CoV-2 Open

Ruili Huang, Miao Xu, Hu Zhu, Catherine Z. Chen, Wei Zhu , et al. · 2021

Taï Forest Virus Does Not Cause Lethal Disease in Ferrets Open

Zachary Schiffman, Feihu Yan, Shihua He, Kevin Tierney, Wenjun Zhu , et al. · 2021

Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates. Among these viruses, those belonging to the Ebolavirus genus—pa…

Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop Open

Logan Banadyga, Wenjun Zhu, Shweta Kailasan, Katie A. Howell, Krzysztof Franaszek , et al. · 2021

Ebola virus remains a global threat to public health and biosecurity, yet we still know relatively little about its pathogenesis and the complications that arise following recovery. With nearly 20,000 survivors from the 2013–2016 West Afri…

Repurposing of Berbamine Hydrochloride to Inhibit Ebola Virus by Targeting Viral Glycoprotein Open

Shan Cen, Dongrong Yi, Quanjie Li, Xiangguo Qiu, Han Wang , et al. · 2020

Ebola virus (EBOV) infection leads to staggeringly high mortality rates. Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa. In this study, we report that a natural compound called berbamine …

Development of an antigen detection assay for early point-of-care diagnosis of Zaire ebolavirus Open

Haley L. DeMers, Shihua He, Sujata G. Pandit, Emily E. Hannah, Zirui Zhang , et al. · 2020

The 2013-2016 Ebola virus (EBOV) outbreak in West Africa and the ongoing cases in the Democratic Republic of the Congo have spurred development of a number of medical countermeasures, including rapid Ebola diagnostic tests. The likelihood …

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2 Open

Ruili Huang, Miao Xu, Hu Zhu, Catherine Z. Chen, Emily M. Lee , et al. · 2020

The recent global pandemic caused by the new coronavirus SARS-CoV-2 presents an urgent need for new therapeutic candidates. While the importance of traditional in silico approaches such as QSAR in such efforts in unquestionable, these mode…

North American deer mice are susceptible to SARS-CoV-2 Open

Bryan D. Griffin, Mable Chan, Nikesh Tailor, Emelissa J. Mendoza, Anders Leung , et al. · 2020

The zoonotic spillover of the pandemic SARS-coronavirus 2 (SARS-CoV-2) from an animal reservoir, currently presumed to be the Chinese horseshoe bat, into a naïve human population has rapidly resulted in a significant global public health e…

Redox-Responsive Transcription Factor 1 (RRFT1) Is Involved in Extracellular ATP-Regulated Arabidopsis thaliana Seedling Growth Open

Ruojia Zhu, Xiao-Xia Dong, Yingying Xue, Jiawei Xu, Aiqi Zhang , et al. · 2020

Extracellular adenosine triphosphate (eATP) is an apoplastic signaling molecule that plays an essential role in the growth and development of plants. Arabidopsis seedlings have been reported to respond to eATP; however, the downstream sign…

Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors Open

Pengfei Fan, Xiangyang Chi, Guodong Liu, Guanying Zhang, Zhengshan Chen , et al. · 2020

Ebola virus (EBOV) can cause severe hemorrhagic fever in humans, and no approved treatment is currently available. Although several antibodies have achieved good protection in animal models, the potential emerging isolates of ebolavirus an…

Correction to: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model Open

Guillaume Poliquin, Duane J. Funk, Shane Jones, Kaylie N. Tran, Charlene Ranadheera , et al. · 2019

Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model Open

Guillaume Poliquin, Duane J. Funk, Shane Jones, Kaylie N. Tran, Charlene Ranadheera , et al. · 2019

Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies Open

Md Niaz Rahim, Min Wang, Tong Wang, Shihua He, Bryan D. Griffin , et al. · 2019

Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication. To generate anti-filovirus monoclonal antibodies (mAbs) against…

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