Shengming Liu
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View article: Curcumin modulates tracheal epithelial cell autophagy in asthma by inhibiting the NF-κB pathway via SCGB3A2
Curcumin modulates tracheal epithelial cell autophagy in asthma by inhibiting the NF-κB pathway via SCGB3A2 Open
This study reveals that curcumin protects against asthma by modulating the SCGB3A2-NF-κB-autophagy axis. These findings highlight this axis as a novel therapeutic target for asthma.
View article: Single-Cell Sequencing Reveals PD-L1-Mediated Immune Escape Signaling in Lung Adenocarcinoma
Single-Cell Sequencing Reveals PD-L1-Mediated Immune Escape Signaling in Lung Adenocarcinoma Open
Background: Lung cancer has the highest mortality rate among all cancers, for which immunotherapy can frequently lead to drug resistance. To understand the molecular mechanisms behind immune escape in patients with lung cancer and develop …
View article: Bronchial thermoplasty decreases airway remodeling by inhibiting autophagy via the AMPK/mTOR signaling pathway
Bronchial thermoplasty decreases airway remodeling by inhibiting autophagy via the AMPK/mTOR signaling pathway Open
Bronchial thermoplasty (BT), an effective treatment for severe asthma, requires heat to reach the airway to reduce the mass of airway smooth muscle cells (ASMCs). Autophagy is involved in the pathological process of airway remodeling in pa…
View article: Clinical characteristics between influenza A and B in emergency from 2018/2019
Clinical characteristics between influenza A and B in emergency from 2018/2019 Open
Objectives: This study analyzed the clinical characteristics and hematologic examination indexes to tell the type of influenza among patients and provide a basis for the early diagnosis and treatment of influenza patients. Methods: We coll…
View article: Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate chronic obstructive pulmonary disease: a multicentre, double-blind, randomised, placebo-controlled trial
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate chronic obstructive pulmonary disease: a multicentre, double-blind, randomised, placebo-controlled trial Open
Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy of N-acetylcysteine (an antioxidant and mucolytic agent) for patients with mild-to-moderate COPD is uncertai…
View article: Cohort Profile: Burden of Obstructive Lung Disease (BOLD) study
Cohort Profile: Burden of Obstructive Lung Disease (BOLD) study Open
Peer reviewed
View article: Photodynamic therapy for treatment of recurrent hemoptysis secondary to pulmonary endometriosis: a case report
Photodynamic therapy for treatment of recurrent hemoptysis secondary to pulmonary endometriosis: a case report Open
Pulmonary endometriosis (PEM) is rare, and drug therapy remains the primary treatment. However, patients with PEM frequently experience recurrent hemoptysis that is refractory to pharmacological intervention. We herein describe a patient w…
View article: Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease
Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease Open
Objectives To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data of 57 COPD patients were randomized into the control ( …
View article: Changes of serum MMP-9, NSE, MPO levels and prognostic influencing factors in patients with intracranial aneurysm undergoing interventional embolization at different treatment timing
Changes of serum MMP-9, NSE, MPO levels and prognostic influencing factors in patients with intracranial aneurysm undergoing interventional embolization at different treatment timing Open
Background: To analyzes the changes in serum levels of matrix metalloproteinase-9 (MMP-9), neuroenolase (NSE), myeloperoxidase (MPO) and prognostic factors in patients with intracranial aneurysm (IA) undergoing interventional embolization …
View article: The Mechanisms of Resistin-Like Molecule-β-Mediated Airway Inflammation in Chronic Obstructive Pulmonary Disease via Autophagy
The Mechanisms of Resistin-Like Molecule-β-Mediated Airway Inflammation in Chronic Obstructive Pulmonary Disease via Autophagy Open
The RELMβ binds to TLR4 to encourage signal transduction and that RELMβ can promote inflammation in smoky COPD lungs through autophagy.
View article: Construction and evaluation of a risk prediction model for pulmonary infection‐associated acute kidney injury in intensive care units
Construction and evaluation of a risk prediction model for pulmonary infection‐associated acute kidney injury in intensive care units Open
Acute kidney injury (AKI) is one of the common complications of pulmonary infections. However, nomograms predicting the risk of early‐onset AKI in patients with pulmonary infections have not been comprehensively researched. In this study, …
View article: CCDC 2246922: Experimental Crystal Structure Determination
CCDC 2246922: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2241680: Experimental Crystal Structure Determination
CCDC 2241680: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2241802: Experimental Crystal Structure Determination
CCDC 2241802: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to non-invasive mechanical ventilation in reducing intubation rate in hypoxia and dyspnea due to acute heart failure: a systematic review and meta-analysis
High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to non-invasive mechanical ventilation in reducing intubation rate in hypoxia and dyspnea due to acute heart failure: a systematic review and meta-analysis Open
To the Editor: Acute heart failure (AHF) is a leading cause of hospitalization. Most patients with AHF present with hypoxia and dyspnea. Treatment of these patients often requires oxygenation via facemask and more intensive respiratory sup…
View article: Exploration and Evaluation of the Long-term Effects of Diverse Online Teaching Methods of Basic Clinical Courses in Clinical Medicine During the COVID-19 Pandemic
Exploration and Evaluation of the Long-term Effects of Diverse Online Teaching Methods of Basic Clinical Courses in Clinical Medicine During the COVID-19 Pandemic Open
To explore and evaluate the long-term effects of diverse online teaching methods to minimize the negative influences of online teaching of basic courses in clinical medicine during the COVID-19 pandemic. Forty-nine students in grade 2017 m…
View article: CCDC 2055059: Experimental Crystal Structure Determination
CCDC 2055059: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2055058: Experimental Crystal Structure Determination
CCDC 2055058: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Research on the Effectiveness and Safety of Bronchial Thermoplasty in Patients with Chronic Obstructive Pulmonary Disease
Research on the Effectiveness and Safety of Bronchial Thermoplasty in Patients with Chronic Obstructive Pulmonary Disease Open
Objective To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating chronic obstructive pulmonary disease (COPD) patients. Methods Clinical data of 57 COPD patients were randomized into control (n = 29, con…
View article: N6-Methyladenosine-Related Long Non-Coding RNAs Are Identified as a Potential Prognostic Biomarker for Lung Squamous Cell Carcinoma and Validated by Real-Time PCR
N6-Methyladenosine-Related Long Non-Coding RNAs Are Identified as a Potential Prognostic Biomarker for Lung Squamous Cell Carcinoma and Validated by Real-Time PCR Open
Currently, the precise mechanism by which N 6 -methyladenosine (m 6 A) modification of long non-coding RNAs (lncRNAs) promotes the occurrence and development of lung squamous cell carcinoma (LUSC) and influences tumor microenvironment (TME…
View article: Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis
Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown origin that usually results in death from secondary respiratory failure within 2–5 years of diagnosis. Recent studies have identified key roles of cytoki…