Shengnan Liu
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View article: Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling Open
Retinal microglia originate during embryonic hematopoiesis and play an essential role in visual function. However, the mechanisms guiding microglial precursors into the retina remain poorly understood. Here, we show that, in zebrafish embr…
View article: Association between PM2.5 exposure with major adverse cardiovascular events and the modification of medical history and green space: A cohort study
Association between PM2.5 exposure with major adverse cardiovascular events and the modification of medical history and green space: A cohort study Open
Exposure to PM2.5 and its components was related to increase incidence of MACE in ACS patients. Public health priority should be provided to individuals with certain medical history and to greenspace expansion.
View article: NRF1/NFE2L1 orchestrates spatiotemporal regulation of protein degradation network in skeletal muscle
NRF1/NFE2L1 orchestrates spatiotemporal regulation of protein degradation network in skeletal muscle Open
Skeletal muscle (SkM) relies on precise regulation of protein synthesis and degradation for functional integrity, with the ubiquitin-proteasome system (UPS) as a cornerstone of homeostasis. Nuclear factor (erythroid-derived 2)-like 1 (NFE2…
View article: Pyrroloquinoline quinone targets senescent osteoclasts and reduces spinal pain and endplate degeneration in a lumbar spine instability mouse model
Pyrroloquinoline quinone targets senescent osteoclasts and reduces spinal pain and endplate degeneration in a lumbar spine instability mouse model Open
View article: Regulation of an lncRNA <i>irf8</i> by the Ikzf1/Myb complex drives neutrophil development
Regulation of an lncRNA <i>irf8</i> by the Ikzf1/Myb complex drives neutrophil development Open
As critical executors of the immune system, neutrophils provide an immediate inflammatory response for the clearance of debris and microbes, which is essential for the protection of health. Developmentally, neutrophils and macrophages shar…
View article: ZmHSCF1 enhances Agrobacterium-mediated transformation frequency in commercial maize inbred lines by promoting embryogenic callus proliferation
ZmHSCF1 enhances Agrobacterium-mediated transformation frequency in commercial maize inbred lines by promoting embryogenic callus proliferation Open
View article: Correction: Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway
Correction: Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway Open
View article: Loss of nucleobindin-2 causes nigrastriatal degeneration in mice by impacting circadian rhythm-related genes and gut microbiota
Loss of nucleobindin-2 causes nigrastriatal degeneration in mice by impacting circadian rhythm-related genes and gut microbiota Open
Nesfatin-1 is a brain-gut peptide encoded by the nucleobindin-2 (NUCB2) gene. We previously demonstrated that a reduced level of nesfatin-1 in the cerebrospinal fluid, induced by intracerebroventricular injection of a nesfatin-1 antibody, …
View article: METHODS AND EXPERIMENTAL STUDY ON THE DETERMINATION OF FRICTION AND MECHANICAL PROPERTY PARAMETERS OF VARIOUS RICE SEED VARIETIES UNDER DIFFERENT CONDITIONS
METHODS AND EXPERIMENTAL STUDY ON THE DETERMINATION OF FRICTION AND MECHANICAL PROPERTY PARAMETERS OF VARIOUS RICE SEED VARIETIES UNDER DIFFERENT CONDITIONS Open
The precise broadcasting technology of rice plays a significant role in the mechanization of planting and yield improvement, with seed friction and mechanical properties being crucial for planter design. Therefore, this study conducted exp…
View article: Efficacy and prognostic factors of anti-VEGF treatment for neovascular age-related macular degeneration: An OCTA imaging-based deep learning analysis
Efficacy and prognostic factors of anti-VEGF treatment for neovascular age-related macular degeneration: An OCTA imaging-based deep learning analysis Open
View article: Sonodynamic and Bioorthogonal Sonocatalytic Thrombotic Therapy Based on AIE Cationic Tetranuclear Ir(III) Complex Nanoplatform Guided by NIR‐Chemiluminescence Imaging
Sonodynamic and Bioorthogonal Sonocatalytic Thrombotic Therapy Based on AIE Cationic Tetranuclear Ir(III) Complex Nanoplatform Guided by NIR‐Chemiluminescence Imaging Open
Non‐invasive thrombolytic strategies include photothermal therapy (PTT), photodynamic therapy (PDT) and sonodynamic therapy (SDT). The development of PTT and PDT is impeded by the limited tissue penetration depth of the light source. SDT i…
View article: Author Correction: Brain milieu induces early microglial maturation through the BAX-Notch axis
Author Correction: Brain milieu induces early microglial maturation through the BAX-Notch axis Open
View article: Global epidemiology and burden of headache disorders in children and adolescents from 1990 to 2021
Global epidemiology and burden of headache disorders in children and adolescents from 1990 to 2021 Open
Objective We aimed to present an updated epidemiological overview of headache disorders among children and adolescents, utilizing the latest data from the Global Burden of Disease (GBD) 2021. Background Large‐sample epidemiological studies…
View article: Changes in the Stress Response and Fitness of Hybrids Between Transgenic Soybean and Wild-Type Plants Under Heat Stress
Changes in the Stress Response and Fitness of Hybrids Between Transgenic Soybean and Wild-Type Plants Under Heat Stress Open
Understanding the ability of hybrids of genetically modified (GM) soybean and wild soybean to survive and reproduce under unfavorable conditions is critical for answering questions regarding risk assessment and the existence of transgenes …
View article: Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin
Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin Open
Hydrogen peroxide (H2O2) plays a crucial role in cell signaling in response to physiological and environmental perturbations. H2O2 can oxidize typical 2-Cys peroxiredoxin (PRX) first into a sulfenic acid, which resolves into a disulfide th…
View article: Establishment of a nomogram model based on immune-related genes using machine learning for aortic dissection diagnosis and immunomodulation assessment
Establishment of a nomogram model based on immune-related genes using machine learning for aortic dissection diagnosis and immunomodulation assessment Open
The clinical manifestation of aortic dissection (AD) is complex and varied, making early diagnosis crucial for patient survival. This study aimed to identify immune-related markers to establish a nomogram model for AD diagnosis. Three data…
View article: Thiamethoxam at environmentally relevant concentrations induces neurotoxicity in zebrafish larvae through binding with multiple receptors
Thiamethoxam at environmentally relevant concentrations induces neurotoxicity in zebrafish larvae through binding with multiple receptors Open
View article: Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway
Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway Open
View article: Metabolizable alloy clusters assemble nanoinhibitor for enhanced radiotherapy of tumor by hypoxia alleviation and intracellular PD-L1 restraint
Metabolizable alloy clusters assemble nanoinhibitor for enhanced radiotherapy of tumor by hypoxia alleviation and intracellular PD-L1 restraint Open
View article: Association of mixed polycyclic aromatic hydrocarbons exposure with hearing loss and the mediating role of blood cell markers of inflammation in U.S. adults
Association of mixed polycyclic aromatic hydrocarbons exposure with hearing loss and the mediating role of blood cell markers of inflammation in U.S. adults Open
Introduction Studies on the effects of polycyclic aromatic hydrocarbons (PAHs) on hearing loss (HL) are limited and often focus on individual PAH compounds. The present study aimed to explore the individual and combined effects of PAH expo…
View article: 340 Efficacy and safety of conditionally-activated CAR-T cells against gastrointestinal tumors
340 Efficacy and safety of conditionally-activated CAR-T cells against gastrointestinal tumors Open
View article: The mechanism of CPT1A involved in hepatocellular carcinoma growth and Bufalin regulates malignant behavior of hepatocellular carcinoma via CPT1A
The mechanism of CPT1A involved in hepatocellular carcinoma growth and Bufalin regulates malignant behavior of hepatocellular carcinoma via CPT1A Open
Objective Cinobufacini exhibits significant anti-cancer effects on various malignant tumors, particularly demonstrating outstanding efficacy against hepatocarcinoma. The anti-tumor effects of Cinobufacini primarily manifest as inhibition o…
View article: Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease
Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease Open
AIM: To describe the multimodal imaging features, treatment, and outcomes of patients diagnosed with adult-onset Coats disease. METHODS: This retrospective study included patients first diagnosed with Coats disease at ≥18 years of age betw…
View article: Gene coexpression network analysis reveals the genes and pathways in pectoralis major muscle and liver associated with wooden breast in broilers
Gene coexpression network analysis reveals the genes and pathways in pectoralis major muscle and liver associated with wooden breast in broilers Open
View article: Diversified Techniques for Restructuring Meat Protein-Derived Products and Analogues
Diversified Techniques for Restructuring Meat Protein-Derived Products and Analogues Open
Accompanied by the rapid growth of the global population and increasing public awareness of protein-rich foods, the market demand for protein-derived products is booming. Utilizing available technologies to make full use of meat by-product…
View article: Sparsity- and Hybridity-Inspired Visual Parameter-Efficient Fine-Tuning for Medical Diagnosis
Sparsity- and Hybridity-Inspired Visual Parameter-Efficient Fine-Tuning for Medical Diagnosis Open
The success of Large Vision Models (LVMs) is accompanied by vast data volumes, which are prohibitively expensive in medical diagnosis.To address this, recent efforts exploit Parameter-Efficient Fine-Tuning (PEFT), which trains a small numb…
View article: Comparative evaluation of fermented ginseng on alleviating antibiotic-associated diarrhea in mice
Comparative evaluation of fermented ginseng on alleviating antibiotic-associated diarrhea in mice Open
View article: The Relationship Between Changes of Left Heart Structure and Function and the Risk of Future Renal Damage in Patients with Essential Hypertension
The Relationship Between Changes of Left Heart Structure and Function and the Risk of Future Renal Damage in Patients with Essential Hypertension Open
In essential hypertensive patients, LVEF and IVST can predict the risk of future adverse renal outcomes. Moreover, combining risk variables into a simplified score may enable to assess the risk of renal impairment in hypertensive patients …
View article: Bioengineering autologous cartilage grafts for functional posterior lamellar eyelid reconstruction: A preliminary study in rabbits
Bioengineering autologous cartilage grafts for functional posterior lamellar eyelid reconstruction: A preliminary study in rabbits Open
The reconstruction of posterior lamellar eyelid defects remains a significant challenge in clinical practice due to anatomical complexity, specialized function, and aesthetic concerns. The ideal substitute for the posterior lamellar should…
View article: A multiscale model of the mammalian liver circadian clock supports synchronization of autonomous oscillations by intercellular communication
A multiscale model of the mammalian liver circadian clock supports synchronization of autonomous oscillations by intercellular communication Open
Expression of core circadian clock genes in hepatocytes across the liver lobule is temporally synchronized despite cell-autonomous oscillations in gene expression. This spatial synchronization has been attributed to an unknown intercellula…