Shengping Hou
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View article: Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation
Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation Open
DNMT3A facilitates lactate transport into the nucleus, where it promotes VEGFA upregulation through HIF-1α lactylation, thereby stimulating endothelial cell angiogenesis. Targeting the lactate-DNMT3A/HIF-1α lactylation/VEGFA pathway could …
View article: Development and validation of a reporter gene assay for the bioactivity determination of anti-TSLP monoclonal antibodies
Development and validation of a reporter gene assay for the bioactivity determination of anti-TSLP monoclonal antibodies Open
Thymic stromal lymphopoietin (TSLP) promotes Th2-mediated inflammation via dendritic cell activation and STAT5 signaling and plays critical roles in inflammatory disorders and allergic diseases. While tezepelumab stands as the first and on…
View article: A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium Open
The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually dec…
View article: BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner
BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner Open
Retinal vascular diseases are typified by the proliferation of irregular and leaky microvessels, resulting in vision impairment. Although the etiology of retinal angiogenesis is not yet fully understood, it is evident that microglia play a…
View article: Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis
Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis Open
Objective Insomnia is increasingly recognized as a significant factor in the development of various autoimmune diseases, including autoimmune uveitis (AU). We investigated insomnia-associated genes that may contribute to AU pathogenesis an…
View article: Multi-gene precision editing tool using CRISPR-Cas12a/Cpf1 system in Ogataea polymorpha
Multi-gene precision editing tool using CRISPR-Cas12a/Cpf1 system in Ogataea polymorpha Open
This novel multiplexed genome-editing tool mediated by CRISPR-Cpf1 can realize the deletion and integration of multiple genes, which holds great promise for accelerating engineering efforts on this non-conventional methylotrophic yeast for…
View article: Gene therapy: New and future treatments for uveitis
Gene therapy: New and future treatments for uveitis Open
Uveitis, characterized by intraocular inflammation, has significant management challenges due to its diverse etiologies and complicated pathophysiology. The current first‐line treatments primarily aim to calm inflammation with the underlyi…
View article: Ocular immune‐related diseases: molecular mechanisms and therapy
Ocular immune‐related diseases: molecular mechanisms and therapy Open
Ocular immune‐related diseases, represent a spectrum of conditions driven by immune system dysregulation, include but not limit to uveitis, diabetic retinopathy, age‐related macular degeneration, Graves’ ophthalmopathy, etc. The molecular …
View article: Time Trends in the Burden of Environmental Heat and Cold Exposure Among Children and Adolescents
Time Trends in the Burden of Environmental Heat and Cold Exposure Among Children and Adolescents Open
Importance Environmental heat and cold exposure (EHCE) remains the principal preventable cause of morbidity and mortality in children and adolescents globally. Objective To report EHCE-related burden and analyze its temporal trends among c…
View article: Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype
Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype Open
Uveitis is a vision-threatening disease primarily driven by a dysregulated immune response, with retinal microglia playing a pivotal role in its progression. Although the transcription factor EGR2 is known to be closely associated with uve…
View article: Appetitive Lifestyles and Obesity with Risk of Senile Cataract: An Univariable and Multivariable Mendelian Randomization Study
Appetitive Lifestyles and Obesity with Risk of Senile Cataract: An Univariable and Multivariable Mendelian Randomization Study Open
Objective: To estimate the causal effects of appetitive lifestyles (cigarette smoking, alcohol use, coffee consumption) and obesity on risk of senile cataract (SC) using genetically based approaches. Methods: Single nucleotide polymorphism…
View article: A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis Open
Background Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased glycolytic rates and lactate accumulation are associated with pathological a…
View article: Icariin alleviates oxygen‐induced retinopathy by targeting microglia hexokinase 2
Icariin alleviates oxygen‐induced retinopathy by targeting microglia hexokinase 2 Open
Retinopathy of prematurity (ROP) is a retinal disease‐causing retinal neovascularization that can lead to blindness. Oxygen‐induced retinopathy (OIR) is a widely used ROP animal model. Icariin (ICA) has anti‐oxidative and anti‐inflammation…
View article: YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes (Adv. Sci. 19/2024)
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes (Adv. Sci. 19/2024) Open
YY1 Lactylation Activated microglia in the retina are essential for the development of autoimmune uveitis. The center of this image presents YY1 lactylation (lactylation at 183 lysine of YY1), which stands between the normal microglia (res…
View article: Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis Open
Autoimmune uveitis (AU) is a kind of immune‐mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to disease initiation and pr…
View article: YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes Open
Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune‐mediated diseases. Here, an increased YY…
View article: OR11H1 Missense Variant Confers the Susceptibility to Vogt‒Koyanagi‒Harada Disease by Mediating Gadd45g Expression
OR11H1 Missense Variant Confers the Susceptibility to Vogt‒Koyanagi‒Harada Disease by Mediating Gadd45g Expression Open
Vogt‒Koyanagi‒Harada (VKH) disease is a severe autoimmune disease. Herein, whole‐exome sequencing (WES) study are performed on 2,573 controls and 229 VKH patients with follow‐up next‐generation sequencing (NGS) in a collection of 2,380 con…
View article: Global lactylome reveals lactylation-dependent mechanisms underlying T <sub>H</sub> 17 differentiation in experimental autoimmune uveitis
Global lactylome reveals lactylation-dependent mechanisms underlying T <sub>H</sub> 17 differentiation in experimental autoimmune uveitis Open
Dysregulation of CD4 + T cell differentiation is linked to autoimmune diseases. Metabolic reprogramming from oxidative phosphorylation to glycolysis and accumulation of lactate are involved in this process. However, the underlying mechanis…
View article: A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing
A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing Open
Vogt–Koyanagi–Harada (VKH) disease is a leading cause of blindness in young and middle-aged people. However, the etiology of VKH disease remains unclear. Here, we performed the first trio-based whole-exome sequencing study, which enrolled …
View article: Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization Open
Apigenin can ameliorate retinal inflammation in IRBP induced autoimmune uveitis through inhibiting microglia M1 pro-inflammatory polarization via TLR4/MyD88 pathway.
View article: Trends and cross-country inequalities in the global burden of osteoarthritis, 1990-2019: a population-based study (Preprint)
Trends and cross-country inequalities in the global burden of osteoarthritis, 1990-2019: a population-based study (Preprint) Open
BACKGROUND Osteoarthritis (OA) is the most common cause of adult activity limitation and a major cause of deformity in aging people, therefore gradually becomes a global public health issue. OBJECTIVE We here provide a comprehensive eva…
View article: Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics
Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics Open
The underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single‐cell RNA sequencing and single‐cell assay for transposase‐accessible chromatin sequencing are perfo…