Shengqian Dou
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View article: Comparative Transcriptomic Profiling of Corneal Compartments Using Single-Cell and Single-Nucleus Sequencing
Comparative Transcriptomic Profiling of Corneal Compartments Using Single-Cell and Single-Nucleus Sequencing Open
Collectively, our findings provide an objective evaluation of scRNA-seq and snRNA-seq performance across corneal cell types, offering practical guidance for selecting optimal sequencing strategies based on specific research requirements.
View article: Single-Cell Transcriptomics Reveals Effects of Long-Term Contact Lens Wearing on the Human Corneal Epithelium
Single-Cell Transcriptomics Reveals Effects of Long-Term Contact Lens Wearing on the Human Corneal Epithelium Open
Long-term wear of CLs may induce various manifestations in corneal epithelial cells, including keratinization, inflammatory response, aerobic metabolic impairment, cellular senescence, neovascularization, and corneal sensory abnormalities.…
View article: Effects of Cholesterol Metabolism on Corneal Endothelial Dysfunction in Patients With Type 1 Diabetes
Effects of Cholesterol Metabolism on Corneal Endothelial Dysfunction in Patients With Type 1 Diabetes Open
Diabetes induced CED by inhibiting SREBF2/SQLE-dependent cholesterol biosynthesis, suggesting cholesterol supplementation protects CECs from damage caused by intraocular surgery in patients with diabetes.
View article: A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway
A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway Open
Tear secretion from the lacrimal gland is essential for maintaining ocular surface homeostasis, and its insufficiency causes aqueous-deficient dry eye. Unlike the well-established parasympathetic neuronal regulation, the role of sympatheti…
View article: Upstream open reading frames buffer translational variability during Drosophila evolution and development
Upstream open reading frames buffer translational variability during Drosophila evolution and development Open
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread cis -re…
View article: Upstream open reading frames buffer translational variability during Drosophila evolution and development
Upstream open reading frames buffer translational variability during Drosophila evolution and development Open
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread cis-reg…
View article: CD4<sup>+</sup>CD25<sup>−</sup> T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice
CD4<sup>+</sup>CD25<sup>−</sup> T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice Open
CD4+CD25- T cells, but not DCs or CD8+ T cells, contribute to corneal nerve degeneration in diabetic mice, a process partially mediated by IFN-γ.
View article: Upstream open reading frames buffer translational variability during Drosophila evolution and development
Upstream open reading frames buffer translational variability during Drosophila evolution and development Open
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread cis-reg…
View article: Upstream open reading frames buffer translational variability during Drosophila evolution and development
Upstream open reading frames buffer translational variability during Drosophila evolution and development Open
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread cis -re…
View article: Corneal strain influences keratocyte proliferation and migration through upregulation of <scp>ALDH3A1</scp> expression
Corneal strain influences keratocyte proliferation and migration through upregulation of <span>ALDH3A1</span> expression Open
Keratocytes are the primary resident cells in the corneal stroma. They play an essential role in maintaining corneal physiological function. Studying the factors that affect the phenotype and behavior of keratocytes offers meaningful persp…
View article: Self‐Cascade API Nanozyme for Synergistic Anti‐Inflammatory, Antioxidant, and Ferroptosis Modulation in the Treatment of Corneal Neovascularization
Self‐Cascade API Nanozyme for Synergistic Anti‐Inflammatory, Antioxidant, and Ferroptosis Modulation in the Treatment of Corneal Neovascularization Open
Corneal neovascularization is a common pathological ocular change that can severely impairs vision, potentially leading to blindness. Although steroids and non‐steroidal anti‐inflammatory drugs are the primary treatments, their side effect…
View article: Natural Extracellular Matrix Scaffold‐Based Hydrogel Corneal Patch with Temperature and Light‐Responsiveness for Penetrating Keratoplasty and Sutureless Stromal Defect Repair
Natural Extracellular Matrix Scaffold‐Based Hydrogel Corneal Patch with Temperature and Light‐Responsiveness for Penetrating Keratoplasty and Sutureless Stromal Defect Repair Open
Corneal transplantation remains the gold standard for treating corneal blindness; however, it is hampered globally by donor shortages and the complexity of suture‐dependent procedures. Tissue‐engineered corneas have demonstrated potential …
View article: Upstream open reading frames buffer translational variability during <i>Drosophila</i> evolution and development
Upstream open reading frames buffer translational variability during <i>Drosophila</i> evolution and development Open
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread cis -re…
View article: CYR61/CCN1: A novel mediator of redox response in corneal stromal cells of keratoconus
CYR61/CCN1: A novel mediator of redox response in corneal stromal cells of keratoconus Open
Keratoconus (KC) is a progressive, multifactorial and ectatic corneal disorder that characterized by steepening thinning of the cornea. It was previously demonstrated that oxidative stress has a strong link with KC progression. However, th…
View article: Cell‐type‐specific mRNA m<sup>6</sup>A landscape and regulatory mechanisms underlying pulmonary injury in COVID‐19
Cell‐type‐specific mRNA m<sup>6</sup>A landscape and regulatory mechanisms underlying pulmonary injury in COVID‐19 Open
Coronavirus disease 2019 (COVID‐19) pandemic has caused millions of deaths. The risk of COVID‐19 spreading still exists after the deconfinement act, Omicron became the dominant variant. Although N6‐methyladenosine (m 6 A) regulators has be…
View article: Decoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing
Decoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing Open
Background Dysfunction or deficiency of corneal epithelium results in vision impairment or blindness in severe cases. The rapid and effective regeneration of corneal epithelial cells relies on the limbal stem cells (LSCs). However, the mol…
View article: Single-Nuclei Characterization of Lacrimal Gland in Scopolamine-Induced Dry Eye Disease
Single-Nuclei Characterization of Lacrimal Gland in Scopolamine-Induced Dry Eye Disease Open
Overall, this study offers a systemic single-nucleus transcriptomic profile of LGs in both normal and DED conditions and an atlas of the complicated interactions of immunocytes with major LG parenchymal cells. The findings also facilitate …
View article: <i>NEAT1</i> Deficiency Promotes Corneal Epithelial Wound Healing by Activating cAMP Signaling Pathway
<i>NEAT1</i> Deficiency Promotes Corneal Epithelial Wound Healing by Activating cAMP Signaling Pathway Open
NEAT1 deficiency contributes to epithelial repair during corneal wound healing by activating the cAMP signaling pathway, thereby highlighting a potential therapeutic strategy for corneal epithelial diseases.
View article: New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration
New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration Open
Keratoconus is a progressive, ectatic and blinding disorder of the cornea, characterized by thinning of corneal stroma. As a highly prevalent among adolescents, keratoconus has been a leading indication for corneal transplantation worldwid…
View article: Single-cell RNA sequencing in cornea research: Insights into limbal stem cells and their niche regulation
Single-cell RNA sequencing in cornea research: Insights into limbal stem cells and their niche regulation Open
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. Its continuous renewal or wound healing depends on …