Shengran Wang
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View article: PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects
PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects Open
This study developed a high-throughput luciferase-based PPARγ-responsive cellular model to screen chemicals that may contribute to PF through the inhibition of PPARγ activity. The model demonstrates potential as a useful tool for prelimina…
View article: Activation of the cGAS-STING pathway in monocytes exacerbates pulmonary fibrosis induced by paraquat poisoning
Activation of the cGAS-STING pathway in monocytes exacerbates pulmonary fibrosis induced by paraquat poisoning Open
Paraquat (PQ), a total contact herbicide, triggers progressive pulmonary fibrosis and multiorgan failure. This toxicity occurs via DNA damage-induced mitochondrial dysfunction and dysregulated extracellular matrix (ECM) remodeling, highlig…
View article: Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats
Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats Open
Introduction Human zona pellucida (ZP) plays an important role in reproductive process. Several rare mutations in the encoding genes ( ZP1 , ZP2 , and ZP3 ) have been demonstrated to cause women infertility. Mutations in ZP2 have been repo…
View article: A Novel Coverage-guided Greybox Fuzzing based on Power Schedule Optimization with Time Complexity
A Novel Coverage-guided Greybox Fuzzing based on Power Schedule Optimization with Time Complexity Open
Coverage-guided Greybox fuzzing is regarded as a practical approach to detect software vulnerabilities, which targets to expand code coverage as much as possible. A common implementation is to assign more energy to such seeds which find ne…