Shengrong Du
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View article: Cryptorchidism: Novel genetic insights into <i>CCDC149</i> mutations
Cryptorchidism: Novel genetic insights into <i>CCDC149</i> mutations Open
Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149 , a coiled‐coil domai…
View article: Label‐Free Multiphoton Microscopy for Diagnosis of Psoriasis
Label‐Free Multiphoton Microscopy for Diagnosis of Psoriasis Open
Psoriasis is a global problem that significantly affects patients both physically and mentally. Accurate and rapid detection of psoriasis is crucial for diagnosis and treatment. Herein, we utilized multiphoton microscopy (MPM) to rapidly i…
View article: Machine learning-enhanced SERS for accurate azoospermia diagnosis via seminal plasma exosome analysis
Machine learning-enhanced SERS for accurate azoospermia diagnosis via seminal plasma exosome analysis Open
Male infertility affects 10–15% of couples globally, with azoospermia — complete absence of sperm — accounting for 15% of cases. Traditional diagnostic methods for azoospermia are subjective and variable. This study presents a novel, nonin…
View article: Single Nucleotide Polymorphism array analysis for fetuses from balanced translocation carriers at the second trimester
Single Nucleotide Polymorphism array analysis for fetuses from balanced translocation carriers at the second trimester Open
Prenatal diagnosis is crucial for pregnancies from couples with a carrier of a balanced translocation. We retrospectively reviewed 195 pregnancies from 189 couples with a balanced translocation carrier. Of these, 126 were from natural conc…
View article: Micro-Raman Spectroscopy Reveals Distinct Differences in Sperm Quality Selected by Hyaluronic Acid
Micro-Raman Spectroscopy Reveals Distinct Differences in Sperm Quality Selected by Hyaluronic Acid Open
View article: Micro-Raman Analysis of Sperm Cells on Glass Slide: Potential Label-Free Assessment of Sperm DNA toward Clinical Applications
Micro-Raman Analysis of Sperm Cells on Glass Slide: Potential Label-Free Assessment of Sperm DNA toward Clinical Applications Open
Routine assessment of sperm DNA integrity involves the time-consuming and complex process of staining sperm chromatin. Here, we report a Raman spectroscopy method combined with extended multiplicative signal correction (EMSC) for the extra…
View article: Emerging Bioactive Agent Delivery-Based Regenerative Therapies for Lower Genitourinary Tissues
Emerging Bioactive Agent Delivery-Based Regenerative Therapies for Lower Genitourinary Tissues Open
Injury to lower genitourinary (GU) tissues, which may result in either infertility and/or organ dysfunctions, threatens the overall health of humans. Bioactive agent-based regenerative therapy is a promising therapeutic method. However, st…
View article: Tripronuclear Zygotes in IVF Laboratory Quality Control: Experimental Evaluation and Potential Applications
Tripronuclear Zygotes in IVF Laboratory Quality Control: Experimental Evaluation and Potential Applications Open
Suzhu Chen,* Pengyu Huang,* Yan Sun,* Shengrong Du, Yunhong Lin, Beihong Zheng, Dianliang Lin Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, 350001, Peopl…
View article: Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation
Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation Open
Hsa_circ_0075691, hsa_circ_0075692 and hsa_circ_0085997 may be potential diagnostic biomarkers of PCOS, but their specific regulatory mechanisms still need to be further studied.
View article: Explore the potential molecular mechanism of polycystic ovarian syndrome by protein–protein interaction network analysis
Explore the potential molecular mechanism of polycystic ovarian syndrome by protein–protein interaction network analysis Open
View article: Validation of Next-Generation Sequencing and Array Comparative Genomic Hybridization for Diagnosis and Screening of Reciprocal and Robertsonian Translocations in Human Blastocysts
Validation of Next-Generation Sequencing and Array Comparative Genomic Hybridization for Diagnosis and Screening of Reciprocal and Robertsonian Translocations in Human Blastocysts Open
Background: Advances in biotechnology, especially next-generation sequencing (NGS) and array comparative genomic hybridization (aCGH) approaches, have improved preimplantation genetic screening; however, these methods have not been directl…
View article: Factors affecting pregnancy outcomes following the surgical removal of intrauterine adhesions and subsequent in vitro fertilization and embryo transfer
Factors affecting pregnancy outcomes following the surgical removal of intrauterine adhesions and subsequent in vitro fertilization and embryo transfer Open
This study aimed to investigate the clinical factors affecting pregnancy rates following the surgical removal of intrauterine adhesions (IUAs) and subsequent in vitro fertilization and embryo transfer (IVF-ET). We retrospectively ev…
View article: Waist Circumference Coupled with Either HDL-C or TG Can Be Used as a Diagnostic Marker for Metabolic Syndrome in Chinese Women with Polycystic Ovary Syndrome
Waist Circumference Coupled with Either HDL-C or TG Can Be Used as a Diagnostic Marker for Metabolic Syndrome in Chinese Women with Polycystic Ovary Syndrome Open
Although quite a few polycystic ovary syndrome (PCOS) patients suffering from metabolic syndrome (MS) have been reported in previous studies, no reliable and early diagnostic biomarkers for MS in PCOS patients have yet been identified. To …
View article: Evaluation and Optimization of Paper-Based SERS Substrate for Potential Label-Free Raman Analysis of Seminal Plasma
Evaluation and Optimization of Paper-Based SERS Substrate for Potential Label-Free Raman Analysis of Seminal Plasma Open
Characterization and optimization of paper SERS substrate were performed in detail, in which morphologies and distribution of silver nanoparticles (AgNPs) on the paper substrate pretreated with different concentrations of NaCl and the subs…