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View article: Age‐Related Anatomical Changes in Carotid Artery Stenosis and Its Impact on Postoperative Complications in Stenting and Endarterectomy
Age‐Related Anatomical Changes in Carotid Artery Stenosis and Its Impact on Postoperative Complications in Stenting and Endarterectomy Open
Aims Carotid artery stenosis increases the risk of ischemic stroke, with carotid endarterectomy (CEA) and carotid artery stenting (CAS) as primary interventions. Age‐related vascular changes may contribute to complications. This study aime…
View article: Aging-dependent expression of vascular endothelial growth factor receptor-1 is associated with T-cell immune senescence in carotid atherosclerosis
Aging-dependent expression of vascular endothelial growth factor receptor-1 is associated with T-cell immune senescence in carotid atherosclerosis Open
BACKGROUND: Immune aging, characterized by altered phenotypes and functions of natural and acquired immunity, constitutes a significant threat indicator factor for atherosclerosis due to its association with chronic inflammation. However, …
View article: <scp>PTP1B</scp> Modulates Carotid Plaque Vulnerability in Atherosclerosis Through Rab5‐<scp>PDGFRβ</scp>‐Mediated Endocytosis Disruption and Apoptosis
<span>PTP1B</span> Modulates Carotid Plaque Vulnerability in Atherosclerosis Through Rab5‐<span>PDGFRβ</span>‐Mediated Endocytosis Disruption and Apoptosis Open
Background Protein tyrosine phosphatase 1B (PTP1B) is a protein tyrosine phosphatase and modulates platelet‐derived growth factor (PDGF)/platelet‐derived growth factor receptor (PDGFR) signaling in vascular smooth muscle cells (VSMCs) via …
View article: Lipotoxicity, the role in the process of atherosclerosis
Lipotoxicity, the role in the process of atherosclerosis Open
Background: Atherosclerosis (AS) is a growing problem in the elderly population causing a variety of diseases with high mortality and disability rates. Lipotoxicity plays an important role in the process of AS. Aim: This review aims to sum…
View article: eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque
eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque Open
View article: ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis
ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis Open
Various signaling pathways are regulated by reactive oxygen species (ROS), which are radical oxygen intermediates under normal physiological conditions. However, when the buffering capacity of antioxidant enzymes is exceeded by the accumul…