Shengyong Yu
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View article: Capture primed pluripotency in guinea pig
Capture primed pluripotency in guinea pig Open
Guinea pigs are valuable models for human disease research, yet the lack of established pluripotent stem cell lines has limited their utility. In this study, we isolate and characterize guinea pig epiblast stem cells (gpEpiSCs) from post-i…
View article: Epigenetic Reshaping through Damage: Promoting Cell Fate Transition by BrdU and IdU Incorporation
Epigenetic Reshaping through Damage: Promoting Cell Fate Transition by BrdU and IdU Incorporation Open
Thymidine analogs have long been recognized for their ability to randomly incorporate into DNA. However, their significance in the chemical induction of pluripotency (CIP) remains unclear. Here, we investigated the impact of BrdU/IdU incor…
View article: Regeneration of the human segmentation clock in somitoids <i>in vitro</i>
Regeneration of the human segmentation clock in somitoids <i>in vitro</i> Open
View article: Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation
Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation Open
The static magnetic fields (SMFs) impact on biological systems, induce a variety of biological responses, and have been applied to the clinical treatment of diseases. However, the underlying mechanisms remain largely unclear. In this repor…
View article: BMP4 drives primed to naïve transition through PGC-like state
BMP4 drives primed to naïve transition through PGC-like state Open
View article: Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency
Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency Open
View article: SS18 regulates pluripotent-somatic transition through phase separation
SS18 regulates pluripotent-somatic transition through phase separation Open
View article: Single Cell Sequencing Reveals Early PGC-like Intermediates During Mouse Primed to Naïve Transition
Single Cell Sequencing Reveals Early PGC-like Intermediates During Mouse Primed to Naïve Transition Open
Single cell analysis provides clarity unattainable with bulk approaches. Here we apply single cell RNA-seq to a newly established BMP4 induced mouse primed to naive transition (Bi-PNT) system and show that the reset is not a direct reversa…
View article: Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4
Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4 Open
Reprogramming somatic cells to pluripotency by Oct4, Sox2, Klf4, and Myc represent a paradigm for cell fate determination. Here, we report a combination of Jdp2, Jhdm1b, Mkk6, Glis1, Nanog, Essrb, and Sall4 (7F) that reprogram mouse embryo…
View article: Induction of Pluripotency by Alternative Factors
Induction of Pluripotency by Alternative Factors Open
View article: Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs)
Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs) Open
Safety issues associated with transcription factors or viruses may be avoided with the use of chemically induced pluripotent stem cells (CiPSCs), thus promoting their clinical application. Previously, we had successfully developed and stan…
View article: Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency
Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency Open
View article: Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function
Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function Open
Polycomb repressive complex 1 (PRC1) plays essential roles in cell-fate determination. Recent studies have found that the composition of mammalian PRC1 is particularly varied and complex; however, little is known about the functional conse…
View article: Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage
Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage Open
We report here an approach to redirecting somatic cell fate under chemically defined conditions without transcription factors. We start by converting mouse embryonic fibroblasts to epithelial-like cells with chemicals and growth factors. S…
View article: Erratum: Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming
Erratum: Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming Open