Shengzhou Shan
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View article: The active metabolite of Epimedii Folium promotes hippocampal neurogenesis in APP/PS1 mice by alleviating mitochondrial dysfunction
The active metabolite of Epimedii Folium promotes hippocampal neurogenesis in APP/PS1 mice by alleviating mitochondrial dysfunction Open
Introduction Alzheimer’s disease (AD), the most common form of dementia, currently has no effective cure. Epimedii Folium (EF), a traditional Chinese medicine known as Yin-yang-huo, has demonstrated significant neuroprotective properties. …
View article: TAGLN-RhoA/ROCK2-SLC2A3-mediated Mechano-metabolic Axis Promotes Skin Fibrosis
TAGLN-RhoA/ROCK2-SLC2A3-mediated Mechano-metabolic Axis Promotes Skin Fibrosis Open
Skin fibrotic diseases are characterized by abnormal fibroblast function and excessive deposition of extracellular matrix. Our previous single-cell sequencing results identified an enriched fibroblast subcluster in skin fibrotic tissues th…
View article: Mechano‐induced arachidonic acid metabolism promotes keratinocyte proliferation through <scp>cPLA2</scp> activity regulation
Mechano‐induced arachidonic acid metabolism promotes keratinocyte proliferation through <span>cPLA2</span> activity regulation Open
Mechano‐induced keratinocyte hyperproliferation is reported to be associated with various skin diseases. Enhanced cell proliferation often requires the active metabolism of nutrients to produce energy. However, how keratinocytes adapt thei…
View article: From solid to fluid: The possible role of tissue fluidity in mechanical stretch-induced tissue expansion
From solid to fluid: The possible role of tissue fluidity in mechanical stretch-induced tissue expansion Open
Tissue expansion is a widely utilized technique in plastic and reconstructive surgery; however, the biological mechanisms underlying the skin response remain poorly understood. We propose that tissue fluidity, the transition of tissue from…
View article: Carbon and energy metabolism for the mixotrophic culture of Chlorella vulgaris using sodium acetate as a carbon source
Carbon and energy metabolism for the mixotrophic culture of Chlorella vulgaris using sodium acetate as a carbon source Open
There has been an emergence of a diversity of microalgal mixotrophic synergistic mechanisms due to substrate differences. In this study, the effects of the mixotrophic culture of Chlorella vulgaris were examined. The maximum values of cell…
View article: Spatial transcriptomic analysis deciphers adipocyte-to-fibroblast transformation in bleomycin-induced murine skin fibrosis
Spatial transcriptomic analysis deciphers adipocyte-to-fibroblast transformation in bleomycin-induced murine skin fibrosis Open
Background: Scleroderma is characterized by inflammation and fibrosis, predominantly occurring in the skin and extending to various parts of the body. The pathophysiology of scleroderma is multifaceted, with the current understanding inclu…
View article: Chemotherapy affects the development of pathological scarring after general thoracic surgery in children
Chemotherapy affects the development of pathological scarring after general thoracic surgery in children Open
Globally, a great number of children have been suffering from physical dysfunction and psychological stress due to uncontrollable scar growth and a lack of effective modalities. Despite chemotherapy's established role as a primary treatmen…
View article: Cultural Identity and Art Education: A Study of the Role of Art College Counselors in a Multicultural Context
Cultural Identity and Art Education: A Study of the Role of Art College Counselors in a Multicultural Context Open
This dissertation explores the roles and functions of art college counselors in supporting students' cultural identity development in a multicultural context. With the acceleration of globalization and the increasing prominence of cultural…
View article: Multidisciplinary treatment of molten aluminum combined burn: An unusual case report
Multidisciplinary treatment of molten aluminum combined burn: An unusual case report Open
Molten aluminum is among the most common causes of burns in the metal industry. However, only few reports are available on molten aluminum injuries. Herein, we report an unusual case of molten aluminum burn. The patient had burns not only …
View article: Mechanical stretch preconditioned adipose‐derived stem cells elicit polarization of anti‐inflammatory M2‐like macrophages and improve chronic wound healing
Mechanical stretch preconditioned adipose‐derived stem cells elicit polarization of anti‐inflammatory M2‐like macrophages and improve chronic wound healing Open
Transplantation of adipose‐derived stem cells (ASCs) is a promising option in the field of chronic wounds treatment. However, the effectiveness of ASCs therapies has been hampered by highly inflammatory environment in chronic wound areas. …
View article: Acellular Dermal Matrix–Assisted Tissue Expansion for Giant Congenital Melanocytic Nevi of the Extremities and Trunk in Pediatric Patients
Acellular Dermal Matrix–Assisted Tissue Expansion for Giant Congenital Melanocytic Nevi of the Extremities and Trunk in Pediatric Patients Open
Background: Tissue expansion for treating giant congenital melanocytic nevi (GCMN) is a commonly used surgical method. However, the procedure’s efficacy is often hindered by anatomical and histologic characteristics and blood supply, parti…
View article: Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop
Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop Open
Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) caused by fibrotic disorders of the skin. In recent years, ECM stiffness has emerged as a prominent mechanical cue that precedes skin fibrosis and d…
View article: Mechanical stiffness promotes skin fibrosis through FAPα-AKT signaling pathway
Mechanical stiffness promotes skin fibrosis through FAPα-AKT signaling pathway Open
Taken together, we identify FAPα as an important driver of mechanical stiffness-induced skin fibrosis and a potential therapeutic target for the treatment of skin fibrosis.
View article: Dynamics of cutaneous atmospheric oxygen uptake in response to mechanical stretch revealed by optical fiber microsensor
Dynamics of cutaneous atmospheric oxygen uptake in response to mechanical stretch revealed by optical fiber microsensor Open
Skin expands and regenerates in response to mechanical stretch. This important homeostasis process is critical for skin biology and can be exploited to generate extra skin for reconstructive surgery. Atmospheric oxygen uptake is important …
View article: Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism
Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism Open
The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether and how cells adapt their metabolic ac…
View article: Loss of HDAC5 Accelerates Joint Destruction and Aging During Osteoarthritis
Loss of HDAC5 Accelerates Joint Destruction and Aging During Osteoarthritis Open
Objectives. Osteoarthritis (OA) lacks effective treatment strategies due to complex pathological mechanisms. In this study, we explored the regulatory role of histone deacetylases 5 (HDAC5) in OA pathogenesis. Methods. The expression of HD…
View article: Recent advances in strategies to target the behavior of macrophages in wound healing
Recent advances in strategies to target the behavior of macrophages in wound healing Open
Chronic wounds and scar formation are widespread due to limited suitable remedies. The macrophage is a crucial regulator in wound healing, controlling the onset and termination of inflammation and regulating other processes related to woun…
View article: The role of microalgae culture modes in aquaculture: a brief opinion
The role of microalgae culture modes in aquaculture: a brief opinion Open
OPINION article Front. Bioeng. Biotechnol., 23 May 2023Sec. Industrial Biotechnology Volume 11 - 2023 | https://doi.org/10.3389/fbioe.2023.1196948
View article: Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction
Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction Open
Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or gastroesophageal sphincters. It is the primary consequence of neuromuscular impairment caused by trauma, inflammation, and aging. Despite intensiv…
View article: Mechanical Stretch Triggers Epithelial-Mesenchymal Transition in Keratinocytes Through Piezo1 Channel
Mechanical Stretch Triggers Epithelial-Mesenchymal Transition in Keratinocytes Through Piezo1 Channel Open
The epithelial-mesenchymal transition (EMT) process has emerged as a central regulator of embryonic development, tissue repair and tumor malignancy. In recent years, researchers have specifically focused on how mechanical signals drive the…
View article: GRK2 Suppresses Hepatocellular Carcinoma Metastasis and Invasion Through Down-Regulation of Prostaglandin E Receptor 2
GRK2 Suppresses Hepatocellular Carcinoma Metastasis and Invasion Through Down-Regulation of Prostaglandin E Receptor 2 Open
Nan Li,* Jing-Jing Wu,* Ting-Ting Chen, Xiu-Qin Li, Jia-Jia Du, Shan Shan, Wei Wei, Wu-Yi Sun Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anh…
View article: Mechanical Stretch Promotes Hypertrophic Scars Formation Through Mechanically Activated Ion Channel Piezo1
Mechanical Stretch Promotes Hypertrophic Scars Formation Through Mechanically Activated Ion Channel Piezo1 Open
BACKGROUND: Hypertrophic scar (HS) formation is abnormal wound healing characterized by hyperactivation of fibroblasts and overproduction of extracellular matrix (ECM). To date, there are few satisfactory treatments.1 Mechanical stress has…
View article: MicroRNA-27a-3p Reverses Adriamycin Resistance by Targeting BTG2 and Activating PI3K/Akt Pathway in Breast Cancer Cells
MicroRNA-27a-3p Reverses Adriamycin Resistance by Targeting BTG2 and Activating PI3K/Akt Pathway in Breast Cancer Cells Open
Bei Zhu,1,2 Weixian Chen,2 Yue Fu,2 Xiaohan Cui,1 Lei Jin,2 Jiadeng Chao,2 Xiao Yun,1,2 Peng Gao,2,3 Shiting Shan,1,2 Jun Li,2,3 Xu Yin,1,2 Chunfu Zhu,2 Xihu Qin2 1Nanjing Medical University, Nanjing 210029, People’s Republic of Chin…
View article: Botulinum Toxin Type A Attenuates Hypertrophic Scars Formation by Preventing Macrophage M1 Polarization
Botulinum Toxin Type A Attenuates Hypertrophic Scars Formation by Preventing Macrophage M1 Polarization Open
BACKGROUND: Botulinum toxin type A has been shown to be a promising therapy for hypertrophic scars by alleviating muscle tension, inhibiting fibroblasts proliferation, and influencing transforming growth factor-β1 expression.1 However, per…
View article: Mechanical Stretch Preconditioned Adipose-derived Stem Cells Improve Impaired Wound Healing by Inducing Macrophage M2 Polarization
Mechanical Stretch Preconditioned Adipose-derived Stem Cells Improve Impaired Wound Healing by Inducing Macrophage M2 Polarization Open
BACKGROUND: Uncontrolled inflammatory response during wound healing leads to aberrant repair. Administration of cells/cell factors capable of screwing polarized macrophages toward the anti-inflammatory M2 has shown a favorable prospect to …