Shenhong Qu
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View article: The relationship between changes in alcohol consumption and hepatic steatosis among alcohol consumers: a large-scale population-based Biobank study
The relationship between changes in alcohol consumption and hepatic steatosis among alcohol consumers: a large-scale population-based Biobank study Open
Background The relationship between changes in alcohol consumption and hepatic steatosis among alcohol consumers remains poorly understood. This study aimed to evaluate the association between changes in alcohol consumption and hepatic ste…
View article: Overexpression of STOML1 is associated with good prognosis in nasopharyngeal carcinoma
Overexpression of STOML1 is associated with good prognosis in nasopharyngeal carcinoma Open
Nasopharyngeal carcinoma (NPC) is a prevalent head and neck malignancy characterized by high recurrence rate, adversely affecting patient prognosis. The present study aimed to identify key genes and mechanisms affecting NPC prognosis using…
View article: Mendelian randomization analysis of gut microbiota-immune cell interactions in malignant neoplasm of nasopharynx
Mendelian randomization analysis of gut microbiota-immune cell interactions in malignant neoplasm of nasopharynx Open
Observational studies have suggested associations among the gut microbiome, immune cells, and the risk of malignant neoplasms of nasopharynx. However, the causality of these relationships remains unclear. Thus, we conducted multiple Mendel…
View article: STIM1 signaling modulates invasive phenotypic plasticity by regulating calpain-dependent cleavage of integrin-β4 in nasopharyngeal carcinoma cells
STIM1 signaling modulates invasive phenotypic plasticity by regulating calpain-dependent cleavage of integrin-β4 in nasopharyngeal carcinoma cells Open
STIM1 signaling promotes invasiveness by enabling accelerated subcellular integrin-β4 redistribution, which is essential for maintaining the invasive plasticity of NPC cells.
View article: Effect of Inorganic Coagulant and Dissolved Organic Matter on the Toxicity of Nano-Zinc Oxide to Phosphorus-Accumulating Organisms in Wastewater
Effect of Inorganic Coagulant and Dissolved Organic Matter on the Toxicity of Nano-Zinc Oxide to Phosphorus-Accumulating Organisms in Wastewater Open
In this study, we aimed to investigate the effects of coagulants and dissolved organic matter (DOM) on the biological toxicity of nano-zinc oxide (nZnO) to key microorganisms involved in biological phosphorus removal during sewage treatmen…
View article: The Effect and Adjustment of Ferrate Species in Ferrate-Based Advanced Oxidation Processes for Wastewater Treatment: A Systematic Review
The Effect and Adjustment of Ferrate Species in Ferrate-Based Advanced Oxidation Processes for Wastewater Treatment: A Systematic Review Open
Interest in the combination of ferrates and advanced oxidation processes (AOPs) for wastewater treatment has increased, as revealed in this systematic review. In this study, the multiple functions of Fe(VI) in ferrate-based AOPs are summar…
View article: Controlled growth of Pr <sub>1.5</sub>Ba <sub>1.5</sub>Cu <sub>3</sub>O <sub>7</sub> cubes to meliorate the cathode reaction for protonic ceramic fuel cells
Controlled growth of Pr <sub>1.5</sub>Ba <sub>1.5</sub>Cu <sub>3</sub>O <sub>7</sub> cubes to meliorate the cathode reaction for protonic ceramic fuel cells Open
Efforts to improve the performance of protonic ceramic fuel cells (PCFCs) have been hampered by the limited availability of cathode materials with high activity and durability. One potential approach to enhance electrocatalytic performance…
View article: Therapeutic effect of umbilical cord mesenchymal stem cells on renal ischemia-reperfusion injury
Therapeutic effect of umbilical cord mesenchymal stem cells on renal ischemia-reperfusion injury Open
Acute kidney injury (AKI) is a growing global health issue with no effective treatments. This study evaluates the therapeutic effects of umbilical cord mesenchymal stem cells (UC-MSCs) on AKI caused by ischemia-reperfusion injury (IRI) in …
View article: An Overview of Recent Advances in Pursuit–Evasion Games with Unmanned Surface Vehicles
An Overview of Recent Advances in Pursuit–Evasion Games with Unmanned Surface Vehicles Open
With the rapid development of perception, decision-making, and control technologies, pursuit–evasion (PE) games with unmanned surface vehicles (USVs) have become an interesting research topic in military implementations and civilian areas.…
View article: Geometric Route Solving of the Observed Parasitic Oscillation and Analysis of Parasitic Oscillation Suppression in an End-Pumped Zigzag Slab Laser
Geometric Route Solving of the Observed Parasitic Oscillation and Analysis of Parasitic Oscillation Suppression in an End-Pumped Zigzag Slab Laser Open
View article: Impact of PDCA cycle-driven nutritional support on serum biomarkers and quality of life in nasopharyngeal carcinoma patients undergoing radiotherapy
Impact of PDCA cycle-driven nutritional support on serum biomarkers and quality of life in nasopharyngeal carcinoma patients undergoing radiotherapy Open
Background: This study aimed to assess the effectiveness of nutritional support guided by the PDCA (Plan-Do-Check-Act) cycle management model in nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. Methods: A total of 100 NPC p…
View article: Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4
Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 Open
lnc-EST885 plays a crucial role in the development of liver cancer, serving as a potential biomarker for predicting HCC prognosis and providing a new target for HCC treatment.
View article: Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial
Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial Open
Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the…
View article: The relationship and clinical significance of lactylation modification in digestive system tumors
The relationship and clinical significance of lactylation modification in digestive system tumors Open
View article: [Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution retrospective study].
[Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution retrospective study]. Open
Objective:To analyze the clinical features, treatment methods and prognosis of radiation-induced sarcoma（RIS） of the head and neck after radiotherapy for nasopharyngeal carcinoma（NPC）, and explore its treatment strategies. Method…
View article: Global trends and hotspots of ChatGPT in medical research: a bibliometric and visualized study
Global trends and hotspots of ChatGPT in medical research: a bibliometric and visualized study Open
Objective With the rapid advancement of Chat Generative Pre-Trained Transformer (ChatGPT) in medical research, our study aimed to identify global trends and focal points in this domain. Method All publications on ChatGPT in medical researc…
View article: Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS‐CoV‐2 Omicron strain infection in China: A national multicenter survey of 35,566 individuals
Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS‐CoV‐2 Omicron strain infection in China: A national multicenter survey of 35,566 individuals Open
Objective This cross‐sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID‐19 in China. Methods This study was conducted by 45 tertiary Grade‐A hospitals in China. Online and offline q…
View article: Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma
Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma Open
Importance There are currently no therapies approved by the US Food and Drug Administration for nasopharyngeal carcinoma (NPC). Gemcitabine-cisplatin is the current standard of care for the first-line treatment of recurrent or metastatic N…
View article: Temporal Findings of Erdheim-Chester Disease A Case Report and Review of the Literature
Temporal Findings of Erdheim-Chester Disease A Case Report and Review of the Literature Open
Introduction: Erdheim-Chester Disease (ECD) is a rare non-Langerhans cell histiocytic disorder, first described in 1930. Its diverse manifestations range from asymptomatic bone lesions to severe systemic involvement. Herein, we report a no…
View article: Symptom clusters after chemoradiotherapy in discharged nasopharyngeal carcinoma patients
Symptom clusters after chemoradiotherapy in discharged nasopharyngeal carcinoma patients Open
Objective To investigate the incidence of complications and types of chemoradiotherepy induces symptom clusters in patients with nasopharyngeal carcinoma (NPC) who were first diagnosed after treatment and discharged from hospital. Methods …
View article: [Diagnosis of nasopharyngeal carcinoma with convolutional neural network on narrowband imaging].
[Diagnosis of nasopharyngeal carcinoma with convolutional neural network on narrowband imaging]. Open
Objective:To evaluate the diagnostic accuracy of the convolutional neural network（CNN） in diagnosing nasopharyngeal carcinoma using endoscopic narrowband imaging. Methods:A total of 834 cases with nasopharyngeal lesions were …
View article: Tislelizumab plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal cancer: A multicenter phase 3 trial (RATIONALE-309)
Tislelizumab plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal cancer: A multicenter phase 3 trial (RATIONALE-309) Open
Checkpoint inhibitors are effective in recurrent/metastatic nasopharyngeal cancer (R/M NPC). RATIONALE-309 (NCT03924986) randomized 263 treatment-naive R/M NPC patients to tislelizumab or placebo every 3 weeks (Q3W), plus chemotherapy (Q3W…
View article: First-in-human phase I/Ib study of QL1706 (PSB205), a bifunctional PD1/CTLA4 dual blocker, in patients with advanced solid tumors
First-in-human phase I/Ib study of QL1706 (PSB205), a bifunctional PD1/CTLA4 dual blocker, in patients with advanced solid tumors Open
Background QL1706 (PSB205) is a single bifunctional MabPair (a novel technical platform) product consisting of two engineered monoclonal antibodies (anti-PD-1 IgG4 and anti-CTLA-4 IgG1), with a shorter elimination half-life (t 1/2 ) for CT…
View article: [Analysis of molecular genetics and clinical characteristics of 3 children with Waardenburg syndrome].
[Analysis of molecular genetics and clinical characteristics of 3 children with Waardenburg syndrome]. Open
Objective:To analyze the molecular genetics and clinical characteristics of 3 children with syndromic deafness were analyzed to clarify their causative genes and genetic characteristics. Methods:The medical records of 3 child…
View article: Efficacy and safety of KL-A167 in previously treated recurrent or metastatic nasopharyngeal carcinoma: a multicenter, single-arm, phase 2 study
Efficacy and safety of KL-A167 in previously treated recurrent or metastatic nasopharyngeal carcinoma: a multicenter, single-arm, phase 2 study Open
View article: Epithelial-mesenchymal transition classification of circulating tumor cells predicts clinical outcomes in progressive nasopharyngeal carcinoma
Epithelial-mesenchymal transition classification of circulating tumor cells predicts clinical outcomes in progressive nasopharyngeal carcinoma Open
Background Liquid biopsy facilitates the enrichment and isolation of circulating tumor cells (CTCs) in various human cancers, including nasopharyngeal carcinoma (NPC). Characterizing CTCs allows observation of the evolutionary process of s…
View article: Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey
Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey Open
Objectives This study aimed to investigate the status of the current knowledge about laryngopharyngeal reflux disease (LPRD) among Chinese otolaryngologists. Design Multi-centre cross-sectional survey. Setting 220 medical centres in differ…
View article: Fluid dynamics of the upper airway in pediatric patients with severe laryngomalacia
Fluid dynamics of the upper airway in pediatric patients with severe laryngomalacia Open
Background: Laryngomalacia is the top cause of pediatric laryngeal wheeze. Objectives: We used computational fluid dynamics to study the inspiratory airflow dynamics in severe pediatric laryngomalacia. Method: Computed tomography was perfo…
View article: Sustained impact of subcutaneous immunotherapy among patients with allergic rhinitis who experienced treatment delay due to the COVID‐19 pandemic: A multicenter, two‐arm, real‐world study
Sustained impact of subcutaneous immunotherapy among patients with allergic rhinitis who experienced treatment delay due to the COVID‐19 pandemic: A multicenter, two‐arm, real‐world study Open
To the editor, Subcutaneous immunotherapy (SCIT) is highly effective for seasonal pollinosis and perennial disease in patients with mite allergy.1 SCIT usually involves administering a gradually increasing dose of the specific allergens to…
View article: ZBTB7A governs 2-DG-inhibited glycolysis by regulating GLUT1 in nasopharyngeal carcinoma
ZBTB7A governs 2-DG-inhibited glycolysis by regulating GLUT1 in nasopharyngeal carcinoma Open
Our previous studies suggested a potential interaction between the POK erythroid myeloid ontogenic factor ZBTB7A and glucose transporter 1 (GLUT1) in nasopharyngeal carcinoma (NPC). This study was designed to confirm the interaction and fu…