Shenqin Yao
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View article: Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species Open
Proper brain function requires the assembly and function of diverse populations of neurons and glia. Single cell gene expression studies have mostly focused on characterization of neuronal cell diversity; however, recent studies have also …
View article: Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species Open
Proper brain function requires the assembly and function of diverse populations of neurons and glia. Single cell gene expression studies have mostly focused on characterization of neuronal cell diversity; however, recent studies have also …
View article: Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks Open
SUMMARY Psilocybin holds promise as a treatment for mental illnesses. One dose of psilocybin induces structural remodeling of dendritic spines in the medial frontal cortex in mice. The dendritic spines would be innervated by presynaptic ne…
View article: Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque Open
Experimental access to cell types within the mammalian spinal cord is severely limited by the availability of genetic tools. To enable access to spinal motor neurons (SMNs) and SMN subtypes, we generated single-cell multiome datasets from …
View article: Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level
Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level Open
Molecularly defined cortical cell types have recently been linked to whole neuronal morphology (WNM), particularly those characterized by whole-brain-wide projections, such as intratelencephalic (IT), extratelencephalic (ET), and corticoth…
View article: Technical and biological sources of noise confound multiplexed enhancer AAV screening
Technical and biological sources of noise confound multiplexed enhancer AAV screening Open
Cis -acting regulatory enhancer elements are valuable tools for gaining cell type-specific genetic access. Leveraging large chromatin accessibility atlases, putative enhancer sequences can be identified and deployed in adeno-associated vir…
View article: Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque Open
Summary Experimental access to cell types within the mammalian spinal cord is severely limited by the availability of genetic tools. To enable access to lower motor neurons (LMNs) and LMN subtypes, we generated single cell multiome dataset…
View article: Data-driven fine-grained region discovery in the mouse brain with transformers
Data-driven fine-grained region discovery in the mouse brain with transformers Open
Spatial transcriptomics offers unique opportunities to define the spatial organization of tissues and organs, such as the mouse brain. We address a key bottleneck in analysis of organ-scale spatial transcriptomic data by establishing a wor…
View article: Author Response: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Author Response: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing Open
Full text Figures and data Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Data availability References Peer review Author response Article and author informat…
View article: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing Open
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the po…
View article: Author Response: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Author Response: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing Open
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the po…
View article: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing Open
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the po…
View article: Connecting single-cell transcriptomes to projectomes in mouse visual cortex
Connecting single-cell transcriptomes to projectomes in mouse visual cortex Open
The mammalian brain is composed of diverse neuron types that play different functional roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of transcriptomically-defined cell types, yet cell type definitio…
View article: Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex Open
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid–producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling pl…
View article: Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species Open
Proper brain function requires the assembly and function of diverse populations of neurons and glia. Single cell gene expression studies have mostly focused on characterization of neuronal cell diversity; however, recent studies have also …
View article: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing Open
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the po…
View article: Reviewer #1 (Public Review): Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Reviewer #1 (Public Review): Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing Open
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the po…
View article: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing Open
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the po…
View article: Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and <i>in situ</i> sequencing
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and <i>in situ</i> sequencing Open
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the po…
View article: Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex
Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex Open
Human cortical interneurons have been challenging to study due to high diversity and lack of mature brain tissue platforms and genetic targeting tools. We employed rapid GABAergic neuron viral labeling plus unbiased Patch-seq sampling in b…
View article: Cardiovascular baroreflex circuit moonlights in sleep control
Cardiovascular baroreflex circuit moonlights in sleep control Open
Sleep disturbances are strongly associated with cardiovascular diseases. Baroreflex, a basic cardiovascular regulation mechanism, is modulated by sleep-wake states. Here, we show that neurons at key stages of baroreflex pathways also promo…
View article: Regional and cell type-specific afferent and efferent projections of the mouse claustrum
Regional and cell type-specific afferent and efferent projections of the mouse claustrum Open
Summary The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. However, its regional anatomy and cell-type-specific connections in the mouse remain largely undetermined. Here, we ac…
View article: Dense functional and molecular readout of a circuit hub in sensory cortex
Dense functional and molecular readout of a circuit hub in sensory cortex Open
Cell type diversity in the neocortex The ability to link molecularly identified neurons with their function during behavior requires monitoring the activity of these cell types in vivo. Condylis et al . developed a platform for population …
View article: A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex
A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex Open
Identification of the structural connections between neurons is a prerequisite to understanding brain function. We developed a pipeline to systematically map brain-wide monosynaptic inputs to specific neuronal populations using Cre-driver …
View article: Cellular anatomy of the mouse primary motor cortex
Cellular anatomy of the mouse primary motor cortex Open
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted 1 . Here,…
View article: A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex
A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex Open
Identification of the structural connections between neurons is a prerequisite to understanding brain function. We developed a pipeline to systematically map brain-wide monosynaptic inputs to specific neuronal populations using Cre-driver …