Shenqiu Zhang
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View article: MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality
MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality Open
The MYC oncoprotein represents an intriguing target for cancer treatment, but its therapeutic potential has been hindered by the absence of specific pharmacological inhibitors. In this study, we demonstrate that the phenoxy quinoline compo…
View article: Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound
Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound Open
Therapeutic targeting of MYC directly has proven difficult, but several means to target MYC indirectly using a synthetic lethal drug approach have been proposed. Synthetic lethal approaches for MYC have sought to take advantage of vulnerab…
View article: Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B
Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B Open
View article: The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells
The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells Open
Small molecule inhibitors of aurora kinases are currently being investigated in oncology clinical trials. The long-term effects of these inhibitors on proliferating euploid cells have not been adequately studied. We examined the effect of …
View article: Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B
Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B Open
We used mechanism-informed phenotypic screening to identify and optimize compounds that phenocopy the genetic depletion of the mitotic aurora kinase B (AURKB) kinase. After assaying nine aryl fused seven-membered lactam compounds, we ident…
View article: The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy
The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy Open
View article: A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil
A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil Open
A synthetic lethal effect arises when a cancer-associated change introduces a unique vulnerability to cancer cells that makes them unusually susceptible to a drug’s inhibitory activity. The synthetic lethal approach is attractive because i…
View article: Emerging Strategies to Attack Polyploid Cancer Cells
Emerging Strategies to Attack Polyploid Cancer Cells Open
Polyploid cancer cells can arise de novo in tumors or they can be induced by therapeutics that inadvertently increase the rate of cytokinetic failure. These cells portend a poor outcome in many cancers because polyploid cancer cells can un…
View article: Pro-survival Bcl-2 Proteins are Modifiers of MYC-VX-680 Synthetic Lethality
Pro-survival Bcl-2 Proteins are Modifiers of MYC-VX-680 Synthetic Lethality Open
The transcription factor encoded by the myelocytomatosis oncogene (MYC) is deregulated by distinct means in different human cancers. Aberrations include chromosomal translocation, amplification, mutation, enhancer activation and post-trans…
View article: A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil
A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil Open
A synthetic lethal effect arises when a cancer-associated change introduces a unique vulnerability to cancer cells that makes them unusually susceptible to a drug’s inhibitory activity. The synthetic lethal approach is attractive because i…
View article: The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells
The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells Open
Inhibition of Aurora-B kinase is a synthetic lethal therapy for tumors that overexpress the MYC oncoprotein. It is currently unclear whether co-occurring oncogenic alterations might influence this synthetic lethality by confering more or l…
View article: Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model
Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model Open
Introduction We develop a multidomain model to predict progression of Alzheimer's disease dementia (AD). Methods Data from the US National Alzheimer's Coordinating Center (n = 3009) are used to examine change in symptom status and to estim…
View article: Vibration Data
Vibration Data Open
The data of human vibration collected in the University of Rochester campus.
View article: Solar and Wind Data
Solar and Wind Data Open
The data of Solar and Wind collected in the University of Rochester campus.
View article: Vibration Data
Vibration Data Open
The data of human vibration collected in the University of Rochester campus.